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カタログ番号 | 製品名 | 別名 | ターゲット |
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T77528 | 5-LOX-IN-2 | Apoptosis , Lipoxygenase | |
5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apopt... | |||
T65427 | 5-LOX inhibitor | 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one | Lipoxygenase |
5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is one of the impurities of itraconazole, a selective LOX-5 inhibitor. | |||
T61211 | 5-LOX-IN-1 | Lipoxygenase | |
5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research. | |||
T8356 | FPL 62064 | Lipoxygenase , COX | |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively). | |||
T78820 | 5-LOX-IN-5 | Lipoxygenase | |
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining to neurodegenerative diseases [1]. | |||
T60630 | COX/5-LOX-IN-1 | ||
COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel... | |||
T61674 | COX-2/5-LOX-IN-1 | ||
COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celec... | |||
T6893 | MK-886 | MK886,L 663536 | Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP |
MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. | |||
T61910 | COX-2/5-LOX-IN-2 | ||
COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ... | |||
T61352 | COX-2/5-LOX-IN-3 | ||
COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro... | |||
T22502 | 2-TEDC | Lipoxygenase | |
2-TEDC is a potent lipoxygenase (LOX) inhibitor with inhibitory effects on 5-LOX, 12-LOX, and 15-LOX with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.2-TEDC can be used in the study of atherosclerosis. | |||
T16503 | PF-4191834 | PF-04191834 | Lipoxygenase |
PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity tow... | |||
T6568 | Licofelone | ML-3000 | Apoptosis , Lipoxygenase , COX |
Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity ass... | |||
T27026 | CJ-13,610 | CJ 13610,CJ-13610 | Lipoxygenase |
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. | |||
T21838 | 1-Naphthyl 3,5-dinitrobenzoate | JMC-4 | Lipoxygenase |
1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy. | |||
T34624 | Setileuton | MK0633,MK 0633,MK-0633 | Lipoxygenase |
Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis. | |||
T25737 | Linetastine | TMK 688,TMK-688,TMK688 | Lipoxygenase , LTR , Histamine Receptor |
Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers. | |||
T8950 | CAY10698 | Lipoxygenase | |
CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM). | |||
T27026L | CJ-13,610 hydrochloride | Lipoxygenase | |
CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs. | |||
T9878 | Croconazole | Lipoxygenase , LTR | |
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno... | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T6576 | Malotilate | Malotilatum,NKK 105,Kantec | Lipoxygenase |
Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis. | |||
T68173 | ZD-2138 | Ici-D2138 | Lipoxygenase |
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolat... | |||
T50071 | Xanthine dehydrogenase Inhibitor 1 | Others | |
5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile is a compound used as a molecular structural unit and is considered to be an inhibitor of enzymes such as COX-2, 5-LOX, etc., and possesses a wide range of... | |||
T7724 | Tepoxalin | RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485 | Lipoxygenase , COX |
Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge... | |||
T8844 | Diflapolin | Others , FLAP , Epoxide Hydrolase | |
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. | |||
T1804 | HPGDS inhibitor 1 | HPGDS-inhibitor-1 | PGE Synthase |
HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM. | |||
T10208 | A-69412 | N-1-(Fur-3-ylethyl)-N-hydroxyurea | Lipoxygenase |
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic... | |||
T10098 | PGS-IN-1 | KME-4 | Lipoxygenase , Prostaglandin Receptor |
PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM). | |||
T71264 | Tenidap Sodium | ||
Tenidap Sodium is a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent. | |||
T19574 | TBHBA | 2,4,6-Tribromo-3-hydroxybenzoic acid | Others |
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a brominated aromatic compound. It has been found to inhibit the enzyme cyclooxygenase-2 (COX-2), the enzyme lipoxygenase (LOX), the enzyme 5-lipoxygenase (5-LOX), the enzy... | |||
T78705 | COX-2-IN-30 | COX | |
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ... | |||
T63215 | COX-2-IN-22 | ||
COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ... | |||
T16817 | S-2474 | Lipoxygenase , COX | |
S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities and inhibits Abeta (25 - 35) and Abeta (1 - 40) induced cell death. | |||
T22172 | YS-121 | ||
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s... | |||
T78706 | COX-2-IN-31 | COX | |
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This... | |||
T81181 | SEH/FLAP-IN-1 | FLAP | |
sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: ... | |||
T22054 | BW 755C | Lipoxygenase | |
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. | |||
T37805 | JKE-1716 | ||
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi... | |||
T15783 | LP117 | Others | |
LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM). | |||
T13263 | COX/5-LO-IN-1 | Atreleuton analog | COX |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T10844 | CMI-392 | Others | |
CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM). | |||
T11864 | Iptacopan | LNP023 | Others |
Iptacopan (LNP023) is an inhibitor with high affinity for factor B. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T8260 | 4',5-Dihydroxyflavone | Lipoxygenase , Glucosidase | |
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM). | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T5714 | 5-O-Demethylnobiletin | 5-DEMETHYLNOBILETIN | Leukotriene Receptor , Lipoxygenase |
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
TN2330 | Phenethyl ferulate | Caffeic Acid 3-Methyl Phenethyl Ester | Lipoxygenase , COX |
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a... | |||
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
T5759 | S-(+)-Marmesin | (+)-Marmesin,(S)-Marmesin,marmesin | Lipoxygenase , COX |
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. | |||
TN1182 | 11-Keto-beta-boswellic acid | 11-Keto-beta-boswellic acid | Leukotriene Receptor , NF-κB , Lipoxygenase |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas... | |||
TN1308 | 6-Hydroxyflavanone | Others , Lipoxygenase , COX , GABA Receptor | |
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r... | |||
T3090 | Abietic Acid | Rosin Acid,L-Abietic acid,Sylvic acid,Abietate | MMP , Lipoxygenase , Antibacterial , PPAR |
Abietic Acid (Sylvic acid) is the primary component of resin acid isolated from rosin. | |||
TJS2190 | Nordihydroguaiaretic acid | NDGA,Dihydronorguaiaretic Acid | Antioxidant , Ferroptosis , Lipoxygenase , Autophagy |
Nordihydroguaiaretic acid (NDGA) (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibito... | |||
T3384 | Wedelolactone | IKK Inhibitor II | Apoptosis , NF-κB , Lipoxygenase , Caspase |
Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05498 | SR-BI/SCARB1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5. | |||
TMPY-05387 | SLAMF7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ... | |||
TMPY-04318 | GRIK2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar... | |||
TMPY-05547 | SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPK-01363 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... | |||
TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... |