検索結果

Search Results for " immunomodulatory "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
TP2315	Glatiramer Acetate		Others
	Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS).		Others
T6761	Ossirene	AS101	IL Receptor , Caspase , Interleukin
	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.		IL Receptor , Caspase , Interleukin
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T0222	Proparacaine hydrochloride	Proparacaine HCl,Proxymetacaine Hydrochloride	Apoptosis , Sodium Channel
	Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by bindi...		Apoptosis , Sodium Channel
T16240	N,N'-Diacetyl-L-cystine	(Ac-Cys-OH)2,DiNAC	Others
	N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL...		Others
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T8799	(E/Z)-IT-603	IT603	Others , NF-κB
	(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity.		Others , NF-κB
T3549	Avadomide	CC 122	Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
	Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.		Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
T1642	Lenalidomide	CC-5013	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T9083	TC11	CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL , Caspase , CDK
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.		BCL , Caspase , CDK
T4543	Telithromycin	HMR3647,Ketek,RU66647	Antibacterial , Antibiotic
	Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis...		Antibacterial , Antibiotic
T25146	Bestim		Others
	Bestim is an immunomodulatory dipeptide that is synthetic.		Others
T20025	Imipramine	HSDB 3100,Melipramine,HSDB3100,Dimipressin,HSDB-3100	Apoptosis
	Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in...		Apoptosis
T1159	Leflunomide	SU101,RS-34821,HWA486	Others , Dehydrogenase , AhR
	Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.		Others , Dehydrogenase , AhR
T25702	Levovirin	ICN-17261,ICN 17261,ICN17261,L-Ribavirin	HCV Protease
	Levovirin (L-Ribavirin), the L-enantiomer of ribavirin, is a guanosine nucleoside analog with immunomodulatory activity and is used in the study of hepatitis C virus infection.		HCV Protease
T13180	TOK-8801		Others
	TOK-8801 is a synthetic dihydroimidazole thiazole carboxamide with immunomodulatory activity that eliminates the stimulatory effects of antibody production by removing T cells.CAS 번호128-63-63-5		Others
T12644L	(S)-Thalidomide	(S)-(-)-Thalidomide	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic and pro-apoptotic activities, and is used in the study of leprosy erythema nodosu...		Apoptosis
T9942	WAY-639418		HIV Protease , CCR
	WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.		HIV Protease , CCR
T27034	CL075	3M002,CL-075	NF-κB , TLR , MyD88
	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I i...		NF-κB , TLR , MyD88
T9906	Ipilimumab		Others
	Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.		Others
T14078	AB928		Adenosine Receptor
	AB928 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. It has immunomodulatory activity[1].		Adenosine Receptor
T15437	GSK3145095		RIP kinase
	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.		RIP kinase
T61107	Tilomisole	Wy 18251	Others
	Tilomisole (Wy 18251) is an orally available benzimidazole thiazole with anti-inflammatory activity and immunomodulatory activity.Tilomisole is used in the study of cancer and inflammation.		Others
T10389	Aspartyl-alanyl-diketopiperazine	DA-DKP	Interleukin
	Aspartyl-alanyl-diketopiperazine (DA-DKP) is a known immunomodulatory molecule from the N terminus of human albumin.		Interleukin
T1532	Pidotimod		Others , Antibacterial
	Pidotimod is a synthetic dipeptide with immunomodulatory properties.		Others , Antibacterial
T37076	Zabedosertib	BAY 1834845	IRAK
	Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential. Zabedosertib protects against acute respiratory distress syndrome, a new study suggests.		IRAK
T1813	VGX-1027	VGX1027,VGX 1027,GIT 27	IL Receptor , TNF , Interleukin
	VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.		IL Receptor , TNF , Interleukin
T68182L	3-Hydroxykynurenamine HCl	3-OH-Kynurenamine HCl,3-Hydroxykynurenamine HCl（99362-47-7 Free base）	Others
	3-Hydroxykynurenamine HCl (3-OH-Kynurenamine HCl) is an immunomodulatory biogenic amine, an intermediate in the catabolism of amino acids, which induces oxidative damage and promotes cell death.		Others
T16809	Rupintrivir	AG-7088,AG7088,Rupintrivirvr	Virus Protease , Antiviral
	Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be u...		Virus Protease , Antiviral
T0213	Thalidomide	Thalomid,Sedoval	Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues
	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
T77404	Tesnatilimab	IPH-23XX,JNJ-64304500,JNJ 4500	Others
	Tesnatilimab is a potent humanized IgG4 monoclonal antibody that binds to the immune-activating receptor NKG2D. Tesnatilimab has potential immunomodulatory and anti-inflammatory activity and can be used to study active u...		Others
T13219	TTA-Q6		Calcium Channel
	TTA-Q6 is a selective T-type Ca2+ channel antagonist with potential antitumor and immunomodulatory activity for the treatment of neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cell...		Calcium Channel
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T8932	GSK046	iBET-BD2	Epigenetic Reader Domain
	GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively). It has immunom...		Epigenetic Reader Domain
T21632	Myoseverin		Others , Microtubule Associated
	Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and str...		Others , Microtubule Associated
T14922	Cefodizime		Antibacterial , Antibiotic
			Antibacterial , Antibiotic
T77401	Bavituximab	Anti-PS MAb 3G4	Others
	Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to ...		Others
T76941	Carotuximab	DE-122,TRC105	TGF-beta/Smad , Immunology/Inflammation related
	Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab h...		TGF-beta/Smad , Immunology/Inflammation related
T11412	IPN60090	GLS1-IN-1	Others , transporter
			Others , transporter
T3614	Inosine pranobex	Groprinosin,Isoprinosine,Immunovir,Delimmun	IL Receptor , HIV Protease
	Inosine pranobex (Delimmun) has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production. Through these effects a...		IL Receptor , HIV Protease
T11449L	Golotimod	Gamma-D-glutamyl-L-tryptophan,SCV 07	Antibiotic
	Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage f...		Antibiotic
T77499	MSU-42011		NOS , Retinoid Receptor , NO Synthase , PERK , Lipid
	MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated anti...		NOS , Retinoid Receptor , NO Synthase , PERK , Lipid
T26101	RM 06	RM06,RM-06
	RM 06 is an immunomodulatory agent containing a peptidyl-hypoxanthine structure.
T26753	BC12-4
	BC12-4 is a novel potent inhibitor of IL-2 secretion, it has potent immunomodulatory activity.
T26752	BC12	BC 12,BC-12
	BC12 exhibits unusually potent immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production.
T39850	Bac2A TFA	Bac2A TFA
	Bac2A TFA is an antimicrobial and immunomodulatory peptide derived from bactenecin. Notably, Bac2A TFA exhibits high efficacy in combating fungal pathogens.
T26121	Rooperol
	Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, antibacterial, anticonvulsant, and antioxidant activities. It is a novel p38α inhibitor.
T34697	Splenopentin	Thymopoietin III pentapeptide (32-36),Splenin pentapeptide (32-36),Arg-lys-glu-val-tyr
	Splenopentin (SP-5) is a synthetic immunomodulatory peptide that can reproduce the biological activity of TP and SP, respectively.

Compounds

Target: IL Receptor, Caspase, Interleukin

Lenalidomide hemihydrate

T22922

Synonym:

Target: TNF, Ligand for E3 Ligase, Molecular Glues

Proparacaine hydrochloride

T0222

Synonym: Proparacaine HCl,Proxymetacaine Hydrochloride

Target: Apoptosis, Sodium Channel

N,N'-Diacetyl-L-cystine

T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

Cilomilast

T6445

Synonym: SB-207499,Ariflo

Target: Others, NF-κB

Avadomide

T3549

Synonym: CC 122

Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase

Lenalidomide

T1642

Synonym: CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

Vidofludimus

T2601

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Sulindac

T0459

Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

TC11

T9083

Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Target: BCL, Caspase, CDK

Telithromycin

T4543

Synonym: HMR3647,Ketek,RU66647

Target: Antibacterial, Antibiotic

Synonym: HSDB 3100,Melipramine,HSDB3100,Dimipressin,HSDB-3100

Target: Apoptosis

Leflunomide

T1159

Synonym: SU101,RS-34821,HWA486

Target: Others, Dehydrogenase, AhR

Levovirin

T25702

Synonym: ICN-17261,ICN 17261,ICN17261,L-Ribavirin

Synonym: (S)-(-)-Thalidomide

Target: HIV Protease, CCR

CL075

T27034

Synonym: 3M002,CL-075

Target: NF-κB, TLR, MyD88

Target: Adenosine Receptor

Aspartyl-alanyl-diketopiperazine

Target: Others, Antibacterial

Synonym: VGX1027,VGX 1027,GIT 27

Target: IL Receptor, TNF, Interleukin

3-Hydroxykynurenamine HCl

T68182L

Synonym: 3-OH-Kynurenamine HCl,3-Hydroxykynurenamine HCl（99362-47-7 Free base）

Target: Others

Rupintrivir

T16809

Synonym: AG-7088,AG7088,Rupintrivirvr

Target: Virus Protease, Antiviral

Thalidomide

T0213

Synonym: Thalomid,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Tesnatilimab

T77404

Synonym: IPH-23XX,JNJ-64304500,JNJ 4500

Target: Calcium Channel

NDMC101

T8550

Synonym:

Target: Others, NF-κB, Proteasome

GSK046

T8932

Synonym: iBET-BD2

Target: Epigenetic Reader Domain

Myoseverin

T21632

Synonym:

Target: Others, Microtubule Associated

Cefodizime

T14922

Synonym:

Target: Antibacterial, Antibiotic

Bavituximab

T77401

Synonym: Anti-PS MAb 3G4

Target: Others

Carotuximab

T76941

Synonym: DE-122,TRC105

Target: TGF-beta/Smad, Immunology/Inflammation related

IPN60090

T11412

Synonym: GLS1-IN-1

Target: Others, transporter

Inosine pranobex

T3614

Synonym: Groprinosin,Isoprinosine,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Golotimod

T11449L

Synonym: Gamma-D-glutamyl-L-tryptophan,SCV 07

Target: NOS, Retinoid Receptor, NO Synthase, PERK, Lipid

Synonym: Thymopoietin III pentapeptide (32-36),Splenin pentapeptide (32-36),Arg-lys-glu-val-tyr

Target:

カタログ番号	製品名	別名	ターゲット
TMS1743	Salvigenin		MAO , Autophagy , ROS Kinase
	Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.		MAO , Autophagy , ROS Kinase
T2598	Thymopentin	TP5	Estrogen/progestogen Receptor , Endogenous Metabolite
	Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. Thymopentin (TP5) is an immunomodulator which has been studied for possibl...		Estrogen/progestogen Receptor , Endogenous Metabolite
T8716	Physalin F		Apoptosis
	Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBM...		Apoptosis
T0437	Inosine	INO 495,NSC 20262	ROS , Endogenous Metabolite , Adenosine Receptor
	Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.		ROS , Endogenous Metabolite , Adenosine Receptor
T13808	P-Coumaric Acid Ethyl Ester	Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate	Others , Drug Metabolite
	p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a potent immunosuppressive agent in treating autoimmune inflammato...		Others , Drug Metabolite
T3672	Nomilin		MAPK
	Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.		MAPK
T2833	Dehydrocostus Lactone	Epiligulyl oxide,(-)-Dehydrocostus lactone	IκB/IKK
	Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.		IκB/IKK
T3408	Syringin	Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine	NOS , Autophagy
	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.		NOS , Autophagy
T3S0807	Berbamine		CaMK , NF-κB , Autophagy
	Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.		CaMK , NF-κB , Autophagy
T19882	Bryonolic acid	UNII-J7YR6A878I,20-epi-Bryonolic acid	Apoptosis , Antioxidant , Calcium Channel
	Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apo...		Apoptosis , Antioxidant , Calcium Channel
T5771	Hypocrellin A		Antibacterial , PKC , Parasite
	Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.		Antibacterial , PKC , Parasite
T0492	Dimethyl fumarate	DMF	Reactive Oxygen Species , HIV Protease , Nrf2 , Endogenous Metabolite , Autophagy
	Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
T2788	Baccatin III	Baccatin Ⅲ	Others
	Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.		Others
T7054	N-Benzoyl-(2R,3S)-3-phenylisoserine	taxol side chain	Antiviral
	N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) is an intermediate in the preparation of potent anticancer drug Paclitaxel, used to study the location of the binding sites. It shows cytotoxic, antiviral and immuno...		Antiviral
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
TN1765	Ingenol-3,4,5,20-diacetonide	Ingenol-3,4:5,20-diacetonide	Others
	Ingenol-3,4,5,20-diacetonide is a natural product isolated from the sap of the Euphorbia plant. It has been found to possess a wide range of biological activities including anti-tumor, anti-inflammatory and immunomodulat...		Others
T5712	Zerumbone		Antioxidant , HSV
	Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory a...		Antioxidant , HSV
T73602	Phosphorylcholine	Phosphocholine	Endogenous Metabolite
	Phosphorylcholine is widely present in the biological world, which is a phospholipid present in the eukaryotic biofilm, and also in the symbiotic bacteria or pathogens associated with eukaryotes. Phosphorylcholine has im...		Endogenous Metabolite
T4A2462	Telocinobufagin	Telobufotoxin,Telocinobufogenin	Others
	1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall...		Others
T1082	Benzyl isothiocyanate	Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester	Apoptosis , Antibacterial , Antibiotic
	Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog...		Apoptosis , Antibacterial , Antibiotic
TN1088	3,5,6,7,8,3',4'-Heptemthoxyflavone	3,3',4',5,6,7,8-heptamethoxyflavone	Others
	3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro...		Others
T0610	Piceatannol	trans-Piceatannol,Astringenin	Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
	Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T64744	Ovalbumins		Endogenous Metabolite
	Ovalbumins is the main protein found in egg whites. Ovalbumins have various biological activities such as antibacterial, anticancer, antihypertensive, antioxidant and immunomodulatory activities. Ovalbumins are the most ...		Endogenous Metabolite
T1257	Bestatin	Ubenimex	Others , Aminopeptidase , Antibacterial , Antibiotic , LTR
	Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Amin...		Others , Aminopeptidase , Antibacterial , Antibiotic , LTR
T1611	Isotretinoin	13-cis-Retinoic acid	Retinoid Receptor , Endogenous Metabolite , Autophagy
	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...		Retinoid Receptor , Endogenous Metabolite , Autophagy
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
TMA2008	3-Hydroxy-1,5-diphenyl-1-pentanone
	(+)-3-Hydroxy-1,5-diphenyl-1-pentanone exhibits both immunomodulatory and anti-tumor activity.
TN5653	Cnidioside B methyl ester
	Cnidioside B exerts little immunomodulatory effect in RAW 264.7 cells.
TN3537	Braylin		IL Receptor , TNF , NF-κB
	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-ÎºB. Braylin is also ...		IL Receptor , TNF , NF-κB
TN4951	Sarracine		Others
	Sarracine and neosarracine show immunomodulatory activities.		Others
TN6510	Cordifolioside A
	Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.
TN4506	(+)-Matairesinol		Akt
	(+)-Matairesinol exhibits immunomodulatory activity; it also shows inhibition of the discoloration of yellowtail dark muscle.		Akt
T12789	S-1-Propenyl-L-cysteine		Others
	S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models.		Others
TN2911	3,9-Dihydroeucomin		IL Receptor
	(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.		IL Receptor
TN4811	Plumieride
	Plumieride has plant growth inhibiting properties, it shows strong fungitoxicity against some dermatophytes causing dermatomycosis to animals and human beings. Plumieride also has antioxidant , and immunomodulatory activ...
TN1549	Damnacanthal		IL Receptor , Akt , Syk
	Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.		IL Receptor , Akt , Syk
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 ...
TN1778	Isoformononetin		IL Receptor , Antifection
	Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estro...		IL Receptor , Antifection
T80939	Triptoquinone H
	Triptoquinone H, a natural product derived from the traditional Chinese medicinal plant Tripterygium hypoglaucu, exhibits potent cytotoxic, immunomodulatory, and anti-inflammatory properties. It is utilized in research c...
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and p...
T75691	Amaroswerin
	Amaroswerin, a bioactive secoiridoid glucoside derived from Swertia mussotii, exhibits anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory properties. It notably inhibits nitric oxide (NO) r...
T80019	17-Hydroxyneomatrine
	17-Hydroxyneomatrine, a compound derived from Sophora flavescens, exhibits multifaceted biological activities, including the inhibition of human cervical carcinoma Hela cell growth, along with broad-spectrum antibacteria...
T75661	Thymopentin acetate
	Thymopentin acetate, primarily secreted by the epithelial cells of the thymic cortex and medulla, serves as an effective immunomodulatory agent. It possesses a short plasma half-life of 30 seconds and significantly enhan...
TN3395	Alpinone 3-acetate		IFNAR
	Alpinone 3-acetate showed anti-inflammatory effects and inhibited the inflammatory response in mouse ear edema models induced by 12-O-tetradecanophenol 13-acetate. Alpinone 3-acetate is a derivative of Alpinone. Alpinone...		IFNAR
TN2169	Saikogenin D		IL Receptor , Calcium Channel , Prostaglandin Receptor
	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellu...		IL Receptor , Calcium Channel , Prostaglandin Receptor
TN2775	2-Methoxystypandrone		MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...
TN5912	Macluraxanthone	3-Hydroxyblancoxanthone	Antioxidant , TNF
	Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the p...		Antioxidant , TNF
------------------------ More ------------------------

天然物製品

Salvigenin

TMS1743

Synonym:

Target: MAO, Autophagy, ROS Kinase

Thymopentin

T2598

Synonym: TP5

Target: Estrogen/progestogen Receptor, Endogenous Metabolite

Synonym: INO 495,NSC 20262

Target: ROS, Endogenous Metabolite, Adenosine Receptor

p-Coumaric Acid Ethyl Ester

T13808

Synonym: Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate

Target: Others, Drug Metabolite

Dehydrocostus Lactone

T2833

Synonym: Epiligulyl oxide,(-)-Dehydrocostus lactone

Target: IκB/IKK

Syringin

T3408

Synonym: Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine

Target: NOS, Autophagy

Berbamine

T3S0807

Synonym:

Target: CaMK, NF-κB, Autophagy

Bryonolic acid

T19882

Synonym: UNII-J7YR6A878I,20-epi-Bryonolic acid

Target: Apoptosis, Antioxidant, Calcium Channel

Hypocrellin A

T5771

Synonym:

Target: Antibacterial, PKC, Parasite

Dimethyl fumarate

T0492

Synonym: DMF

Target: Reactive Oxygen Species, HIV Protease, Nrf2, Endogenous Metabolite, Autophagy

N-Benzoyl-(2R,3S)-3-phenylisoserine

T7054

Synonym: taxol side chain

Target: Antiviral

Tripterin

T3028

Synonym: Celastrol,Tripterine

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Ingenol-3,4,5,20-diacetonide

TN1765

Synonym: Ingenol-3,4:5,20-diacetonide

Target: Antioxidant, HSV

Phosphorylcholine

T73602

Synonym: Phosphocholine

Target: Endogenous Metabolite

Telocinobufagin

T4A2462

Synonym: Telobufotoxin,Telocinobufogenin

Target: Others

Benzyl isothiocyanate

T1082

Synonym: Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

3,5,6,7,8,3',4'-Heptemthoxyflavone

TN1088

Synonym: 3,3',4',5,6,7,8-heptamethoxyflavone

Target: Others

Piceatannol

T0610

Synonym: trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Saikosaponin A

T2768

Synonym:

Target: NF-κB, Antibacterial, Liver X Receptor

Ovalbumins

T64744

Synonym:

Target: Endogenous Metabolite

Bestatin

T1257

Synonym: Ubenimex

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Isotretinoin

T1611

Synonym: 13-cis-Retinoic acid

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Allicin

T3123

Synonym:

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Negletein

T2S0843

Synonym: 7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

3-Hydroxy-1,5-diphenyl-1-pentanone

TMA2008

Synonym:

Target:

Cnidioside B methyl ester

Target: IL Receptor, TNF, NF-κB

S-1-Propenyl-L-cysteine

Target: IL Receptor, Akt, Syk

Target: IL Receptor, Antifection

Target: IL Receptor, Calcium Channel, Prostaglandin Receptor

2-Methoxystypandrone

TN2775

Synonym:

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Macluraxanthone

TN5912

Synonym: 3-Hydroxyblancoxanthone

Target: Antioxidant, TNF

--------- More ---------

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-06983	IFN gamma Protein, Human, Recombinant (E. coli)	Human	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPK-00172	B7-H4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A solu...
TMPK-00314	B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s...
TMPK-01017	B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s...
TMPK-01018	B7-H3 Protein, Human, Recombinant (aa 29-245, His)	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s...
TMPK-00637	IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His)	Cynomolgus	HEK293 Cells
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated...
TMPK-01016	B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s...
TMPK-00315	B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s...
TMPK-00889	IFNAR2 Protein, Human, Recombinant (aa 27-243, His)	Human	HEK293 Cells
	Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated...
TMPJ-00076	IL-28B Protein, Human, Recombinant	Human	HEK293 Cells
	Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to pla...
TMPJ-01371	Limitin Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN-α, IFN-β, and IFN-ω and binds to the IFN-α/β receptors. Like IFN-α and IFN-β, limitin...