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阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T6554	JZL 184	JZL184	Lipase
	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.		Lipase
T23498	UNC3230	UNC 3230	Others
	UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C.		Others
T9461	AZ194		Sodium Channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.		Sodium Channel
T1191L	Metamizole sodium	Analgin,Dipyron	COX
	Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.		COX
T22733	DL-AP5		NMDAR
	DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.		NMDAR
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T11516	GV-196771A		NMDAR
			NMDAR
T28118	MSP3	MSP-3,MSP 3	TRP/TRPV Channel
	MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.		TRP/TRPV Channel
T22051	BU 224 hydrochloride		Imidazoline Receptor
	BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.		Imidazoline Receptor
T21380	Pravadoline	WIN 48098-6,WIN48098-6,WIN-48098-6	Cannabinoid Receptor
	Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan...		Cannabinoid Receptor
TP2036L	DPDPE TFA (88373-73-3 free base)	DPDPE TFA	Opioid Receptor
	DPDPE TFA is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.		Opioid Receptor
T23076L	Nociceptin (1-7) acetate		Opioid Receptor
	Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity.		Opioid Receptor
T39284	EST73502 HCl		Opioid Receptor
	EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.		Opioid Receptor
T23331	SC 51089	SC 51089 free base	Prostaglandin Receptor
	SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's...		Prostaglandin Receptor
TP1905	BW-180C	DADLE	Opioid Receptor
	BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.		Opioid Receptor
T17309	(R)-(-)-Ibuprofen	levibuprofen,(R)-Ibuprofen	NF-κB
	(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.		NF-κB
T0678	Amitriptyline hydrochloride	Amitriptyline HCl,Tryptizol,Domical,Annoyltin	Trk receptor , Sigma receptor , 5-HT Receptor , Serotonin Transporter , Sodium Channel , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
TP1212	N-Boc-Phe-Leu-Phe-Leu-Phe	Boc-FLFLF	Others
	N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) (Boc-FLFLF) is a formyl peptide receptor 1 (FPR1) antagonist, which increases pain effects and inhibits antinociceptive activity of annexin. Boc-Phe-Leu-Phe-Leu-Phe is used extensive...		Others
T10593	BPR1M97		Opioid Receptor
			Opioid Receptor
TP1404L	Hemorphin-7 acetate(152685-85-3 free base)		Opioid Receptor
	Hemorphin-7 acetate is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors an...		Opioid Receptor
T4411	DAMGO TFA (78123-71-4(Free base))		Opioid Receptor
	Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food int...		Opioid Receptor
TP1179L	Porcine dynorphin A(1-13) acetate	Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)	Opioid Receptor
	Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) cause...		Opioid Receptor
T22037	AS 1892802		ROCK
	AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 ...		ROCK
T34081	Piromelatine	NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
	Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T10572	BMT-124110		AAK1 (AP2 associated kinase 1)
	BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an...		AAK1 (AP2 associated kinase 1)
T8414	SNC 80	Snc-80,SNC80,NIH 10815	Opioid Receptor
	SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 show...		Opioid Receptor
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
TP1901L1	Hemopressin (rat) acetate(568588-77-2 free base)		Cannabinoid Receptor
	Hemopressin (rat) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB2 cannabinoid recept...		Cannabinoid Receptor
TP1900L1	Hemopressin (human, mouse) acetate	Hemopressin (human, mouse) acetate(1314035-51-2 free base)	Cannabinoid Receptor
	Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabino...		Cannabinoid Receptor
T4436	RO1138452	CAY10441	Others , Prostaglandin Receptor
	RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli...		Others , Prostaglandin Receptor
T23580	20681-S	20681 S
	20681-S has narcotic antagonistic properties and antinociceptive.
T70728	Vadaclidine
	Vadaclidine is an orally acting antinociceptive muscarinic agonist.
T27363	FR 64822	FR-64822,FR64822
	FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptiv...
T20912	DBO-83	DBO83
	DBO-83, an agonist of nicotinic acetylcholine receptors (nAChRs), has anti-amnesic and antinociceptive activities.
T69847	O-1057 free base
	O-1057 free base is a water-soluble cannabinoid receptor agonist with antinociceptive properties. RESEARCH USE ONLY.
T61708	AZD 2066 hydrate
	AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].
T69134	Metanicotine
	Metanicotine is a selective nicotinic agonist with antinociceptive properties.
T27968	M-5011	T-3788,S-MTPPA,M 5011,M-5011C
	M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially i...
T72151	(D-Met2,Pro5)-Enkephalinamide
	(D-Met2,Pro5)-Enkephalinamide, a highly potent opiate agonist, exhibits significant antinociceptive activity.
T69848	O-1057 hydrochloride
	O-1057 hydrochloride is a water-soluble cannabinoid receptor agonist with antinociceptive properties. RESEARCH USE ONLY.
TP2118	SNX-482	SNX 482
	Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
T68206	Arbortristoside A
	Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and ...
T72007	COR167
	COR167 is a CB2 agonist. It displayed potent immunomodulatory activity on immune cells from healthy subjects and patients with multiple sclerosis. It also showed protective effects on rat brain tissues toward ischemia an...
T11721L	JDTic dihydrochloride		JAK
	JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.		JAK
T70292	DDPM-2571 HCl
	DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and...
T25490	Hemorphin 4	Tyr-pro-trp-thr
	Hemorphin 4 is an endogenous opioid peptide of the hemorphin family which has antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.
TP1529	Galanin (1-19), human
	Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulati...
T15165	DPI-3290	Org 41793	Opioid Receptor
	DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally...		Opioid Receptor
T28495	R-84760 hydrochloride	R84760,R 84760,R 86436,R-86436,R86436
	R-84760 is a κ-opioid receptor agonist. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are th...
T28516	ReN-1869	NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869
	ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and ne...

Compounds

Target: Sodium Channel

Metamizole sodium

T1191L

Synonym: Analgin,Dipyron

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

Target: TRP/TRPV Channel

BU 224 hydrochloride

T22051

Synonym:

Target: Imidazoline Receptor

Pravadoline

T21380

Synonym: WIN 48098-6,WIN48098-6,WIN-48098-6

Target: Cannabinoid Receptor

DPDPE TFA (88373-73-3 free base)

TP2036L

Synonym: DPDPE TFA

Target: Opioid Receptor

Nociceptin (1-7) acetate

T23076L

Synonym:

Target: Opioid Receptor

EST73502 HCl

T39284

Synonym:

Target: Opioid Receptor

SC 51089

T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

BW-180C

TP1905

Synonym: DADLE

Target: Opioid Receptor

(R)-(-)-Ibuprofen

T17309

Synonym: levibuprofen,(R)-Ibuprofen

Target: NF-κB

Amitriptyline hydrochloride

T0678

Synonym: Amitriptyline HCl,Tryptizol,Domical,Annoyltin

Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

N-Boc-Phe-Leu-Phe-Leu-Phe

Target: Opioid Receptor

Hemorphin-7 acetate(152685-85-3 free base)

TP1404L

Synonym:

Target: Opioid Receptor

DAMGO TFA (78123-71-4(Free base))

T4411

Synonym:

Target: Opioid Receptor

Porcine dynorphin A(1-13) acetate

TP1179L

Synonym: Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)

Target: Opioid Receptor

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

BMT-124110

T10572

Synonym:

Target: AAK1 (AP2 associated kinase 1)

SNC 80

T8414

Synonym: Snc-80,SNC80,NIH 10815

Target: Opioid Receptor

Ziconotide Acetate (107452-89-1 free base)

TP1559L

Synonym: Prialt,Ziconotide Acetate

Target: Calcium Channel

Hemopressin (rat) acetate(568588-77-2 free base)

TP1901L1

Synonym:

Target: Cannabinoid Receptor

Hemopressin (human, mouse) acetate

TP1900L1

Synonym: Hemopressin (human, mouse) acetate(1314035-51-2 free base)

Target: Cannabinoid Receptor

RO1138452

T4436

Synonym: CAY10441

Target: Others, Prostaglandin Receptor

Synonym: FR-64822,FR64822

Synonym: T-3788,S-MTPPA,M 5011,M-5011C

Target:

(D-Met2,Pro5)-Enkephalinamide

JDTic dihydrochloride

Synonym: Tyr-pro-trp-thr

Target:

Galanin (1-19), human

Target: Opioid Receptor

R-84760 hydrochloride

T28495

Synonym: R84760,R 84760,R 86436,R-86436,R86436

Target:

ReN-1869

T28516

Synonym: NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869

Target:

カタログ番号	製品名	別名	ターゲット
T7907	7-Methoxyflavone		Others
	7-Methoxyflavone isolated from Zornia brasiliensis with antinociceptive effects.		Others
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
T3254	PHYTOL	trans-Phytol,(E)-Phytol	Antibacterial , PPAR , Parasite
	PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects....		Antibacterial , PPAR , Parasite
T3834	8-Epideoxyloganic acid		ROS , Immunology/Inflammation related
	8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl...		ROS , Immunology/Inflammation related
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T8014	Epoxylinalool	2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran	Others
	Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) is a naturally occurring monoterpene alcohol widely used in the production of perfumes and flavors.		Others
T5S2360	Corydaline	Corydalin,(+)-Corydaline	P450 , Virus Protease , Opioid Receptor , AChE
	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...		P450 , Virus Protease , Opioid Receptor , AChE
T0437	Inosine	INO 495,NSC 20262	ROS , Endogenous Metabolite , Adenosine Receptor
	Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.		ROS , Endogenous Metabolite , Adenosine Receptor
T5S1882	Songorine	Napellonine,Zongorine,Bullatine G	Others , GABA Receptor
	Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.		Others , GABA Receptor
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T5S1131	Ganoderic acid C6		Others
	1. Ganoderic acid C6 has antinociceptive activity.		Others
T20225	Dicentrine, (-)-	L-Dicentrine,NSC 251699,NSC251699,NSC-251699	Others
	Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice.		Others
TN2540	1-Hydroxybaccatin I		Others
	1-Hydroxybaccatin I possesses significant antinociceptive activity against p- benzoquinone-induced abdominal contractions.		Others
T2757	Myricitrin	Myricetrin,Myricitrine	PKC
	Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.		PKC
T6S0743	Sesamoside		Others
	Sesamoside has antinociceptive activity.		Others
TN1027	β-Amyrin	beta-Amyrin	Beta Amyloid
	β-Amyrin (beta-Amyrin) has antiviral, hepatoprotective, antinociceptive, anti-inflammatory		Beta Amyloid
TN1823	Kaempferol 3-O-β-D-galactopyranoside	Kaempferol 3-O-beta-D-galactoside,Kaempferol-3-O-galactoside	Immunology/Inflammation related
	Kaempferol 3-O-β-D-galactopyranoside has antioxidant, anti-inflammatory and antinociceptive activities.		Immunology/Inflammation related
T7035	ANTHRAQUINONE-2-CARBOXYLIC ACID		IRAK , Syk
	Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of fruits and herbs.		IRAK , Syk
T5783	Rosamultin		Antioxidant , HIV Protease
	Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.		Antioxidant , HIV Protease
T4833	Ac-DL-Trp-OH	N-Acetyl-DL-tryptophan	Others , Endogenous Metabolite
	Ac-DL-Trp-OH (N-Acetyl-DL-tryptophan) was study for its possible anti- inflammatory and antinociceptive activities from the extraction of a Turkish plant, Salsola grandis.		Others , Endogenous Metabolite
T8169	Decursinol		Others
	Decursinol is isolated from the roots of Angelica Gigas with an antinociceptive effect. It also has anti-tumor and anti-metastasis activity.		Others
T5S0662	Gelsemine	Gelsemin	Antioxidant
	1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance...		Antioxidant
T3409	Plantamajoside	Y0160,C10485	Others
	Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.		Others
T6S0627	Mesaconitine		TNF
	1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.		TNF
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T5814	Aurantiamide	TMC-58B	p38 MAPK , NF-κB
	Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimula...		p38 MAPK , NF-κB
TN1712	Gossypin		NF-κB , S6 Kinase
	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...		NF-κB , S6 Kinase
TN1403	Arjunolic acid		IL Receptor , TNF , Reactive Oxygen Species , JNK , AChE
	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheim...		IL Receptor , TNF , Reactive Oxygen Species , JNK , AChE
T4S1990	Carvacrol	Karvakrol,O-Thymol,cymophenol	Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal
	1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami...
TN2031	γ-Terpinene	Moslene,p-Mentha-1,4-diene,Crithmene	Antioxidant
	γ-Terpinene (p-Mentha-1,4-diene) is a monoterpene compound with high antioxidant properties suitable for oral consumption. It displays direct radical scavenging abilities and is known to be a potent antinociceptive agent...		Antioxidant
TN1377	α-Spinasterol	alpha-Spinasterol	COX , Antibacterial , TRP/TRPV Channel
	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v...		COX , Antibacterial , TRP/TRPV Channel
TN1413	Atranorin		Endogenous Metabolite , NO Synthase , Ras
	Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv...		Endogenous Metabolite , NO Synthase , Ras
T5S0581	Sec-O-Glucosylhamaudol	Hamaudol 3-glucoside	Others , Opioid Receptor
	Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo...		Others , Opioid Receptor
T6S1369	Vitexin	Apigenin-8-C-glucoside	Antioxidant
	1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit...		Antioxidant
T10191L	7-Chlorokynurenic acid	7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA	GluR , NMDAR
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...		GluR , NMDAR
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T6S1579	Monotropein	Monotropeine	Others
	1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf...		Others
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
TN1059	Ganoderic acid B		IL Receptor , HIV Protease , JAK , STAT
	Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has an...		IL Receptor , HIV Protease , JAK , STAT
TN4141	Glochidone		Others
	Glochidone shows pronounced antinociceptive properties in mice.		Others
TN1989	Niga-ichigoside F1		Others , Nrf2
	Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.		Others , Nrf2
TCS2336	Evodine		P-gp
	1. Evodine has antinociceptive activity.		P-gp
TN4777	Physalin G		Others
	Physalin G has antinociceptive property.		Others
TN4440	Limonexic acid		GABA Receptor
	Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.		GABA Receptor
TN1890	Lupeol acetate		Others , TNF , NOS
	Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone.		Others , TNF , NOS
TN3476	Baccatin VI		Others
	Baccatin VI possesses significant antinociceptive activity against p-benzoquinone-induced abdominal contractions.		Others
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天然物製品

Target: Tyrosinase, COX, HDAC, AChR

PHYTOL

T3254

Synonym: trans-Phytol,(E)-Phytol

Target: Antibacterial, PPAR, Parasite

8-Epideoxyloganic acid

T3834

Synonym:

Target: ROS, Immunology/Inflammation related

Albiflorin

T6S1653

Synonym: Alibiflorin

Target: Reactive Oxygen Species

Epoxylinalool

T8014

Synonym: 2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran

Target: Others

Corydaline

T5S2360

Synonym: Corydalin,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Inosine

T0437

Synonym: INO 495,NSC 20262

Target: ROS, Endogenous Metabolite, Adenosine Receptor

Songorine

T5S1882

Synonym: Napellonine,Zongorine,Bullatine G

Target: Others, GABA Receptor

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Synonym: L-Dicentrine,NSC 251699,NSC251699,NSC-251699

Synonym: Myricetrin,Myricitrine

Kaempferol 3-O-β-D-galactopyranoside

TN1823

Synonym: Kaempferol 3-O-beta-D-galactoside,Kaempferol-3-O-galactoside

Target: Immunology/Inflammation related

ANTHRAQUINONE-2-CARBOXYLIC ACID

Target: Antioxidant, HIV Protease

Ac-DL-Trp-OH

T4833

Synonym: N-Acetyl-DL-tryptophan

Target: Others, Endogenous Metabolite

Synonym: Y0160,C10485

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Aurantiamide

T5814

Synonym: TMC-58B

Target: p38 MAPK, NF-κB

Gossypin

TN1712

Synonym:

Target: NF-κB, S6 Kinase

Arjunolic acid

TN1403

Synonym:

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Carvacrol

T4S1990

Synonym: Karvakrol,O-Thymol,cymophenol

Target: Apoptosis, Others, Gamma-secretase, Endogenous Metabolite, Antifungal

γ-Terpinene

TN2031

Synonym: Moslene,p-Mentha-1,4-diene,Crithmene

Target: Antioxidant

α-Spinasterol

TN1377

Synonym: alpha-Spinasterol

Target: COX, Antibacterial, TRP/TRPV Channel

Atranorin

TN1413

Synonym:

Target: Endogenous Metabolite, NO Synthase, Ras

Sec-O-Glucosylhamaudol

T5S0581

Synonym: Hamaudol 3-glucoside

Target: Others, Opioid Receptor

Vitexin

T6S1369

Synonym: Apigenin-8-C-glucoside

Target: Antioxidant

7-Chlorokynurenic acid

T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA

Target: GluR, NMDAR

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Monotropein

T6S1579

Synonym: Monotropeine

Target: Others

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Linalool

T2S2264

Synonym: Linalol,(±)-Linalool,Phantol

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Methyl eugenol

T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether

Target: GABA Receptor

Ganoderic acid B

TN1059

Synonym:

Target: IL Receptor, HIV Protease, JAK, STAT

Target: GABA Receptor

Lupeol acetate

TN1890

Synonym:

Target: Others, TNF, NOS

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04121	NAGA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NAGA (Alpha-N-Acetylgalactosaminidase) is a Protein Coding gene. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. It belongs to ...

NAGA Protein, Human, Recombinant (His)

TMPY-04121

Species: Human

Expression System: HEK293 Cells