Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
説明 | ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). |
ターゲット&IC50 | 15-LOX:200 nM |
In vitro | ML351 exhibited nanomolar potency and excellent selectivity (>250-fold) versus 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. In mouse neuronal HT22 cells, ML351 dose-dependently protected against oxidative glutamate toxicity and completely reversed the increase in 12-HETE following glutamate treatment [2][3] |
分子量 | 249.27 |
分子式 | C15H11N3O |
CAS No. | 847163-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (90.26 mM)
You can also refer to dose conversion for different animals. 詳細
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ML351 847163-28-4 Metabolism Lipoxygenase Subarachnoid hemorrhage ML-351 inhibit oxidative stress SAH neuronal ML 351 LOX T1D β-cell Inhibitor non-obese diabetic inhibitor