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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T39849 | Propargite | Parasite | |
Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 μM [1] . | |||
T8982 | RH01687 | Others | |
RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. | |||
T9696 | β-catenin-IN-2 | Wnt/beta-catenin | |
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research. | |||
T13867 | RH01386 | Others | |
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... | |||
TP1328 | TB500 | Others | |
TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. | |||
T2055 | WS3 | EGFR , IκB/IKK | |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
T76392 | β-Bag cell peptide | ||
β-Bag cell peptide, a neuroactive peptide, elevates cyclic AMP levels and reduces the amplitudes of voltage-dependent potassium currents [1] in bag cell neurons. | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T15159 | Dorzagliatin | HMS5552 | Glucokinase |
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. | |||
T1900 | LDN-212854 | LDN212854,BMP Inhibitor III | ALK , TGF-beta/Smad |
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. | |||
T1674 | Nateglinide | A4166,Senaglinide | Potassium Channel , Proteasome , PPAR |
Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins... | |||
T10460 | Batabulin | T138067 | Apoptosis , Microtubule Associated |
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... | |||
T40187 | GNF2133 | DYRK | |
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes. | |||
T7799 | BMP signaling agonist sb4 | SB 4 | TGF-beta/Smad |
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM) | |||
T6496 | Vactosertib | TEW-7197,EW-7197 | ALK , TGF-beta/Smad |
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... | |||
T1244 | Celiprolol hydrochloride | Selecor,Selectrol | Adrenergic Receptor |
Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION. | |||
T1989 | Luminespib | AUY922,VER-52296,NVP-AUY922 | Apoptosis , HSP , Autophagy |
Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay). | |||
TP1955L | PKC β pseudosubstrate acetate | Protein kinase C beta pseudosubstrate,PKC beta pseudosubstrate,PKC β pseudosubstrate acetate (172308-76-8 Free base) | PKC |
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC. | |||
T9642 | ZW4864 free base | Wnt/beta-catenin | |
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM an... | |||
T61194 | D75-4590 | Others | |
D75-4590 is a β-1,6-Glucan inhibitor. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, D75-4590 can fight fungal infections by inhibiting its synthetase. | |||
T62483 | CJJ300 | TGF-beta/Smad | |
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration. | |||
T9662 | SRI 37892 | Wnt/beta-catenin | |
SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability. | |||
T7204 | PNU-74654 | Apoptosis , Wnt/beta-catenin | |
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. | |||
T8329 | AR 231453 | GPR | |
AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function. | |||
T3074 | CHIR 98024 | CHIR98014 | GSK-3 , S6 Kinase |
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. | |||
TP1125 | Insulin(cattle) | Insulin from bovine pancreas | IGF-1R |
Insulin bovine (Insulin from bovine pancreas) is a biologically derived two-chain polypeptide hormone, synthesized in vivo by pancreatic β cells. It is frequently utilized as a growth supplement in cell culture applicati... | |||
T10904 | CWP232228 | Wnt/beta-catenin | |
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... | |||
T2106 | WS6 | EGFR , IκB/IKK | |
WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
T2386 | Pirfenidone | S-7701,AMR-69,S-7701,AMR69 | CCR , TGF-beta/Smad |
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum... | |||
T11447 | GNF4877 | GSK-3 , DYRK | |
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells. | |||
T23601 | ABC1183 | ABC 1183,ABC-1183 | GSK-3 , CDK |
ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen ... | |||
T61722 | ZDLD20 | Apoptosis | |
ZDLD20 is an orally active and selective CDK4 inhibitor, a β-carboline analog with anti-HCT116 and anticancer activity that inhibits colony formation, inhibits invasion and migration, induces apoptosis, and prevents the ... | |||
T21979 | P32/98 hemifumarate | P32/98 (hemifumarate)(136259-20-6 free base) | DPP-4 |
P32/98 hemifumarate is a dipeptidyl peptidase IV (DPP4) inhibitor with hypoglycemic properties that improves insulin sensitivity and β-cell responsiveness in the Zucker diabetic rat model, and may be useful in studies of... | |||
T6143 | PI-103 | PI103,PI 103 | Apoptosis , DNA-PK , PI3K , mTOR , Autophagy |
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK). | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T4079 | LY-294002 hydrochloride | SF 1101,LY 294002,NSC 697286 | PI3K |
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... | |||
T16028 | IMB-XH1 | Mcl1-IN-2 | BCL , Antibacterial |
IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor. | |||
T4400 | DIM-C-pPhOH | CDIM8 | Apoptosis , Others |
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... | |||
T37445 | Etanercept | TNF | |
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TN... | |||
T8651 | CAL-101 | (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib | PI3K |
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than... | |||
TP2487 | Oligopeptide-68 Acetate | Oligopeptide-68 Acetate(1206525-47-4 Free base) | Others |
Oligopeptide-68 Acetate is a peptide. It is a novel whitening ingredient that mimics the binding of TGF-β to cell surface receptors to reduce induced and hereditary pigmentation by inhibiting MITF intramolecular channels... | |||
T6961 | PX-478 | PX-478 2HCl | HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy |
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di... | |||
T39965 | NF-κΒ activator 1 | NF-κB | |
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide ... | |||
T60485 | DIF-3 | ||
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal... | |||
TP1330 | Cyclo(RADfK) | Integrin | |
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a negative control for the cyclo (-RGDfK-), the RGD peptide. RGD... | |||
T77701 | FL118 | FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin | Survivin |
FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s... | |||
T15616 | JNJ-10198409 | JNJ-10198409 | PDGFR |
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, ant... | |||
T17228 | Sabizabulin | ABI-231,VERU-111 | Microtubule Associated |
Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervica... | |||
T76763 | Teplizumab | PRV-031,MGA-031 | Others |
Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes. | |||
T1005L | Amoxicillin trihydrate | Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,Moxaline trihydrate | Antibacterial , Antibiotic |
Amoxicillin trihydrate (Moxaline trihydrate) binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Amoxicillin trihydrate is a broad-spectrum, semisyntheti... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1019 | Beta-mangostin | β-Mangostin | Apoptosis , Antibacterial , Parasite |
Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo... | |||
TN1471 | Cassiaside C | Toralactone 9-O-β-D-gentiobioside | Others , Endogenous Metabolite |
Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE). | |||
T1286 | Vincamine | Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval | GPR , Others |
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. | |||
TN1017 | Physion 8-O-β-D-glucoside | Physcion 1-O-beta-D-glucoside | Others |
Physion 8-O-β-D-glucoside is a tumor cell growth inhibitor. | |||
T4864 | Methyl β-D-Galactopyranoside | Methyl-β-D-galactopyranoside | Others , Endogenous Metabolite |
Within the cell, Methyl β-D-Galactopyranoside (Methyl-β-D-galactopyranoside) is primarily located in the cytoplasm. Outside of the human body, Methyl β-D-Galactopyranoside can be found in cereals and cereal products. | |||
T13476 | β-Elemene | (-)-β-Elemene,Levo-β-elemene | Apoptosis |
β-Elemene (Levo-β-elemene) is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis. | |||
T5646 | Cinnamic acid | 3-Phenylacrylic acid,β-Phenylacrylic acid | Endogenous Metabolite |
Cinnamic acid (β-Phenylacrylic acid) has potential use in cancer intervention,The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung ca... | |||
T4869 | D-Allose | β-D-Allopyranose,D-(+)-ALLOSE | Others , Endogenous Metabolite |
D-Allose (β-D-Allopyranose) is a rare naturally occurring monosaccharide known to exert anti-proliferative effects on cancer cells. The effects of D-Allose on the cellular membranes of hormone-refractory prostate cancer ... | |||
T3388 | Calycosin-7-O-β-D-glucoside | calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside | MMP , Reactive Oxygen Species |
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos... | |||
TN7052 | Crocin III | Crocetin-mono-(β-D-gentiobiosyl)-ester | Others |
Crocin III (Crocetin-mono-(β-D-gentiobiosyl)-ester) is a crocin derived from saffron (Crocus sutivus L.). Crocins inhibit the cell growth of tumor cells and have anti-inflammatory activity. | |||
T3330 | Trans-Trimethoxyresveratrol | trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene | Reactive Oxygen Species |
trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy... | |||
T4721 | β-Nicotinamide mononucleotide | β-NM | Others , Endogenous Metabolite |
β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD... | |||
T5679 | (E)-Ferulic acid | trans-Ferulic acid,(E)-Coniferic acid | BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite |
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr... | |||
T2S0618 | β-Elemonic Acid | 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid | Apoptosis , Reactive Oxygen Species , COX |
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel... | |||
T19606 | Xylan | Others | |
Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. | |||
T4915 | β-Glycerophosphate disodium salt hydrate | Phosphatase , Endogenous Metabolite | |
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It func... | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T2O2707 | D-(+)-Fucose | Others | |
1. D-(+)-Fucose is a hexose deoxy sugar found on N-linked glycans that appears on the cell surface of mammalian and plant cells. | |||
T4S1943 | Kirenol | Kirel | Wnt/beta-catenin |
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... | |||
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
T4S0350 | Licochalcone B | Beta Amyloid , Others | |
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. 2. LCB and Licoc... | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
TN2371 | Isoliquiritin | Neoisoliquiritin | Others |
Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway | |||
T83573 | (2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol | ||
(2′S)-4′-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranosylvisamminol, a chromone glycoside, can be isolated from the roots of Saposhnikovia divaricata and exhibits weak anti-cancer activity in human cancer cell lines [1]. | |||
TN4383 | Kazinol U | IL Receptor , IκB/IKK , NOS , NF-κB | |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-... | |||
T75621 | Secalonic acid D | ||
Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc exp... | |||
TN6399 | 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane | ||
1-(3',5'-dimethoxy)phenyl-2-[4''-O-β-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane showed cytotoxic activities to Hela and hep2 cell lines. | |||
T15638 | K-252c | PKC | |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ... | |||
T75622 | β-Apopicropodophyllin | ||
β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potentia... | |||
T75634 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | ||
Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity. It hinders tumor cell proliferation and growth by binding to and inhibiting DNA-binding proteins [1]. | |||
T81524 | Peimisine 3-O-β-D-glucopyranoside | ||
Peimisine 3-O-β-D-glucopyranoside (Compound 1), a steroid alkaloid, is isolated and purified from Fritillaria unibracteata and demonstrates a moderate protective effect against rotenone-induced neurotoxicity in the PC12 ... | |||
TN4918 | Roseoside | (6S,9R)-roseoside,Roseoside A | Antioxidant |
Roseoside ((6S,9R)-roseoside), a sesquiterpenoid isolated from Catharanthus roseus, has strong antioxidant and proinsulinic activity, inhibits lipid oxidation, enhances insulin release from the β-cell line INS-1, and can... | |||
T81540 | Parthenosin | Quercetin 3-O-β-D-glucuronide butyl ester | |
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester), a flavonoid derived from the aerial parts of Calligoum polygonoides, exhibits cytotoxic properties with IC50 values of 60.46 μg/mL for HepG2 and 61.4 μg/mL for MCF... | |||
T79976 | Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside | HBV | |
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside serves as an anti-hepatitis B virus (anti-HBV) agent, effectively inhibiting the secretion of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) in the Hep G2.2... | |||
TN4263 | Isoangustone A | MMP , GSK-3 , NF-κB , ROS , Akt , PI3K , CDK , JNK | |
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoang... | |||
TN3753 | Dalbergioidin | Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad | |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or... | |||
T37272 | 9(S),12(S),13(S)-TriHOME | ||
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble ... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-00113 | CD79B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD79B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 45-65 KDa and the accession number is P40259. | |||
TMPJ-00258 | TGF beta 2 Protein, Human, Recombinant | Human | HEK293 Cells |
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. T... | |||
TMPJ-00261 | TGF beta 2 Protein, Mouse/Rat, Recombinant | Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci... | |||
TMPJ-00092 | CD8 beta Protein, Human, Recombinant (His) | Human | HEK293 Cells |
T-Cell Surface Glycoprotein CD8β Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a ... | |||
TMPJ-00897 | TPSB2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Tryptase beta-2(Tpsb2), also known as Mast cell protease 6(mMCP-6), belongs to the peptidase S1 family and Tryptase subfamily. Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled... | |||
TMPJ-00112 | CD79B Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD79B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 30-40 KDa and the accession number is P40259. | |||
TMPJ-00862 | CD79B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD79B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-65 KDa and the accession number is P15530. | |||
TMPJ-00118 | CD79B Protein, Rhesus macaque, Recombinant (hFc) | Rhesus | HEK293 Cells |
CD79B Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-60 KDa and the accession number is H9ZFT8. | |||
TMPJ-00259 | TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated | Human | HEK293 Cells |
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and the accession number is P61812. | |||
TMPJ-00229 | SLAMF5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
SLAMF5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-43 KDa and the accession number is Q9UIB8. | |||
TMPJ-00228 | SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 40-50 KDa and the accession number is Q9UIB8. | |||
TMPJ-00216 | IL-12B Protein, Human, Recombinant | Human | HEK293 Cells |
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, a... | |||
TMPJ-00249 | TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated | Human | HEK293 Cells |
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-... | |||
TMPK-00831 | Galectin-3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the ... | |||
TMPK-00369 | HGF Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different i... | |||
TMPJ-01469 | NGF Protein, Human, Recombinant (E. colli) | Mouse | E. coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ... | |||
TMPJ-00651 | CD155/PVR Protein, Human, Recombinant (aa 21-343, His) | Human | HEK293 Cells |
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entr... | |||
TMPK-00481 | PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity ... | |||
TMPK-00744 | LRP-6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ... | |||
TMPJ-00771 | TGF beta 1 Protein, Mouse/Rat, Recombinant | Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differen... | |||
TMPK-00329 | TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated | Human | HEK293 Cells |
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign... | |||
TMPJ-01371 | Limitin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN-α, IFN-β, and IFN-ω and binds to the IFN-α/β receptors. Like IFN-α and IFN-β, limitin... | |||
TMPK-00328 | TGFBR2 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 Cells |
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign... | |||
TMPJ-00786 | ITGB1 Protein, Human, Recombinant (aa 21-728, His) | Human | HEK293 Cells |
Integrin β-1 (ITGB1) belongs to the integrin β chain family. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue ... | |||
TMPY-05291 | CD57/B3gat1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited down... | |||
TMPK-00925 | Noggin/NOG Protein, Mouse, Recombinant | Mouse | HEK293 Cells |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... | |||
TMPK-01083 | ASPH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPK-00945 | ASPH Protein, Human, Recombinant (His) | Human | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPJ-00415 | HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated | Human | HEK293 Cells |
Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un... | |||
TMPK-00743 | LGR-5 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker... | |||
TMPK-01049 | CLEC7A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis... | |||
TMPK-00926 | Noggin/NOG Protein, Mouse, Recombinant (His & Flag) | Mouse | HEK293 Cells |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G... | |||
TMPK-00022 | Galectin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Galectin 1 (Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has be... | |||
TMPK-00829 | Galectin-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has bee... | |||
TMPY-03457 | ERH Protein, Human, Recombinant (His) | Human | E. coli |
ERH(enhancer of rudimentary homolog) belongs to the E(R) family. It is expressed in all tissues examined. The monomeric structure of ERH comprises a single domain consisting of three α-helices and four β-strands, which... | |||
TMPJ-00457 | OGG1 Protein, Human, Recombinant | Human | E. coli |
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido... | |||
TMPJ-00160 | EMMPRIN/CD147 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane ... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... | |||
TMPY-01846 | Activin A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two ... | |||
TMPY-03627 | CREB3L1 Protein, Human, Recombinant (aa 396-519, His) | Human | HEK293 Cells |
CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mR... | |||
TMPJ-00688 | Persephin Protein, Human, Recombinant | Human | E. coli |
Persephin is a secreted protein, belongs to the glial cell linederived neurotrophic factor (GDNF) family of the TGF-β superfamily. It shares 38-46% amino acid (aa) identity with family members GDNF, neurturin and artemin... | |||
TMPJ-00304 | ALK-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi... | |||
TMPJ-01411 | HSPB11 Protein, Human, Recombinant (His) | Human | E. coli |
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT2... | |||
TMPY-01052 | R-Cadherin/CDH4 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) region... | |||
TMPJ-00238 | Lefty-A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma... | |||
TMPJ-01234 | IL-36 gamma Protein, Mouse, Recombinant | Mouse | E. coli |
Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in b... | |||
TMPJ-00292 | CD36 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ... | |||
TMPJ-00993 | CCL5 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory s... | |||
TMPY-00681 | BMP-5 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily.... | |||
TMPJ-01290 | Neurturin Protein, Human, Recombinant | Human | E. coli |
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Simila... | |||
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カタログ番号 | 製品名 | ||
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L9820 | Beta-Lactam Compound Library | 97 compounds | |
A unique collection of 97 beta-lactam compounds, can be used in HTS and HCS; | |||
L4100 | TGF-beta/Smad Compound Library | 184 compounds | |
A unique collection of 184 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; | |||
L1110 | Microtubule-Targeted Compound Library | 142 compounds | |
A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS; |