Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
説明 | PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo. |
ターゲット&IC50 | Smo:5.8 nM (IC50), Smo:Ki: 4.6 nM |
別名 | PF-5274857 freebase |
分子量 | 436.96 |
分子式 | C20H25ClN4O3S |
CAS No. | 1373615-35-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (286.07 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PF-5274857 1373615-35-0 Stem Cells Smo inhibit driven PF-5274857 freebase PF5274857 metastasis pathway Smoothened PF 5274857 Inhibitor brain tumor inhibitor