Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spinocerebellar ataxia (SCA) and essential tremor (ET).
説明 | Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spinocerebellar ataxia (SCA) and essential tremor (ET). |
In vitro | Rimtuzalcap (Compound 1), a small-molecule modulator of potassium ion channels, exhibits significant therapeutic promise for addressing a range of diseases. These diseases are marked either by the dysfunction of potassium ion channels or by other factors affecting these channels[1]. |
In vivo | Rimtuzalcap (CAD-1883) effectively decreases Purkinje cell firing rate by about 40%, aligning with its expected therapeutic action of enhancing SK channel activity through positive allosteric modulation. When applied in sequence, either 1 or 3 µM of CAD-1883 can partially reverse the augmented coefficient of variation in interspike intervals noted in cerebellar slices from 11-month-old spinocerebellar ataxia-2 58Q mice[1]. |
別名 | CAD-1883 |
分子量 | 378.42 |
分子式 | C18H24F2N6O |
CAS No. | 2167246-24-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (660.64 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rimtuzalcap 2167246-24-2 Membrane transporter/Ion channel Potassium Channel KcsA movement small-conductance channels CAD1883 CAD 1883 SK channels CAD-1883 tremor essential inhibit spinocerebellar potassium ataxia SCA Inhibitor disorders calcium-activated inhibitor