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T16980 |
Taminadenant
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Adenosine Receptor
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Taminadenant is an adenosine receptor antagonist. |
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T9522 |
Rimtuzalcap
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CAD-1883 |
Potassium Channel
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Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin... |
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T12877L |
Seltorexant
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JNJ-42847922 |
OX Receptor
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Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... |
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T7943 |
Fluphenazine decanoate
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Dopamine Receptor
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Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. |
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T71138L |
Binospirone
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MDL 73005EF |
5-HT Receptor
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Binospirone (MDL 73005EF) is a 5-HT1A receptor agonist with anxiolytic activity used in the study of glaucoma and movement disorders associated with neurologic dysfunction. |
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T0719 |
Tetrabenazine
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Xenazine,Ro 1-9569 |
Others
,
Dopamine Receptor
,
Monoamine Transporter
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Tetrabenazine (Ro 1-9569) is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high... |
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T72170 |
NaV1.2/1.6 channel blocker-1
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Sodium Channel
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NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker with inhibitory effects on rNaV1.6 and hNaV1.2.NaV1.2 channel blocker-1 can be used in the study of generalised epilepsy and movement disorders. |
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T67882 |
(2R,3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol
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Others
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(2R,3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. |
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T1776L |
Plerixafor octahydrochloride
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JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl |
Virus Protease
,
HIV Protease
,
CXCR
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Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a... |
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T22576 |
Anpirtoline hydrochloride
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D-16949 hydrochloride |
5-HT Receptor
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Anpirtoline hydrochloride (D-16949 hydrochloride) is a novel and potent 5-HT1B receptor agonist and 5-HT3 receptor antagonist with anti-injurious, analgesic, and antidepressant activity, and is used in the study of movem... |
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T1751 |
Eliprodil
|
SL-820715 |
NMDAR
,
iGluR
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Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa... |
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T37816 |
SB 243213
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5-HT Receptor
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SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders. |
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T2162 |
Maribavir
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BW1263W94,GW257406X,Benzimidavir,1263W94 |
Others
,
HCV Protease
|
|
Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nucle... |
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T70044 |
Sarizotan HCl
|
EMD 128130 HCl |
Dopamine Receptor
,
5-HT Receptor
,
HER
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Sarizotan HCl (EMD 128130 HCl) is an orally active 5-HT1A receptor and dopamine receptor agonist and hERG channel inhibitor with antidepressant activity for the study of movement disorders in Parkinson;s disease. |
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T16811 |
RWJ-51204
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|
GABA Receptor
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RWJ-51204 is a selective adenosine A2A receptor antagonist and a partial agonist of GABA(A) receptor (IC50: 0.2-2 nM). It has neuroprotective and movement-improving effects and can be used in research related to Parkinso... |
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T10826 |
CK-666
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|
HIV Protease
,
Microtubule Associated
|
|
CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex. It binds to the Arp2/3 complex, stabilizes the inactive state of the complex, blocking the movement of the Arp2 and Arp3 subunits into the act... |
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T31264 |
Deanol acetamidobenzoate
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Deanol p-acetamidobenzoate,Elevan,Diforene,Cervoxan,Deaner |
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Deanol acetamidobenzoate is CNS stimulant. It can be caused elevated blood choline levels, can be used in Treatment of Choreiform Movement Disorders. |
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T2507L2 |
Azeliragon HCl
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TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488 |
|
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Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the... |
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T26260 |
Tetrabenazine methanesulfonate
|
NSC169886,NSC 169886,NSC-169886 |
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Tetrabenazine methanesulfonate is a medicine formerly utilized as an antipsychotic and therapy for various movement disorders. Tetrabenazine methanesulfonate blocks neurotransmitter uptake into adrenergic storage vesicle... |
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T68216 |
Sanguiin h 11
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|
|
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Sanguiin h 11 is a compound purified from the plant Sanguisorba officinalis and has proven to be a potent inhibitor of chemoattractant-dependent and independent neutrophil movement. |
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T26342 |
YH16899
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YH-16899,YH 16899,BC-K-YH16899 |
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YH16899 is a KRS-67LR interaction inhibitor by directly blocking the association between KRS and 67LR, suppressing the dynamic movement of the N-terminal extension of KRS and reducing membrane localization of KRS. |
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T17047 |
Tetrabenazine-d6
|
Ro 1-9569 D6 |
Others
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Tetrabenazine D6 is the deuterium-labeled Tetrabenazine. Tetrabenazine is a VMAT-inhibitor used for the treatment of hyperkinetic movement disorder. |
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T36591 |
ABD459
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|
|
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ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours ... |
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T62380 |
20-HC-Me-Pyrrolidine
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|
|
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20-HC-Me-Pyrrolidine was A potent inhibitor of Aster protein, with IC50 values of 0.11 μM, 0.06 μM and 0.71 μM for Aster A, Aster B and Aster C, respectively. 20-HC-Me-Pyrrolidine prevents Aster protein from binding and ... |
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T81803 |
MFN2 agonist-1
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|
|
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MFN2 agonist-1 (B-A/l) effectively induces mitochondrial fusion in cells deficient in mitofusin 2 (MFN2). It counteracts mitochondrial "clumping" (formation of static mitochondrial aggregates) and reinstates mitochondria... |
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T63590 |
C-Met-IN-10
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|
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c-Met-IN-10 is a potent c-Met kinase inhibitor (IC50: 16 nM). c-Met-IN-10 inhibits the activity of cancer cells A549, H460 and HT-29, and inhibits A549 cell movement by inhibiting HT-29 cell colony formation, which in tu... |
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T78827 |
CVN417
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|
|
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CVN417 is an orally active antagonist of nAChR containing the α6 subunit, modulating phasic dopaminergic neurotransmission in an impulse-dependent fashion. It inhibits Ca(2+) efflux through nAChR subunits, displaying IC5... |
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T83851 |
Tat-QFNP12 TFA
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|
|
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Tat-QFNP12 is a peptide that combines a transcriptional transactivator (Tat) transmembrane domain with an inhibitor targeting the interaction between N-Myc downstream regulated gene 2 (NDRG2) and protein phosphatase Mg2+... |
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T83702 |
E70K TFA
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|
|
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E70K is a compound that inhibits the interaction between the chemokine (C-X-C) ligand 8 (CXCL8) and glycosaminoglycans (GAGs) on cell membrane surfaces. It mimics a segment of the CXCL8 protein's GAG-binding region at th... |
