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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T40042 | Evifacotrep | TRP/TRPV Channel | |
Evifacotrep is a short transient receptor potential channel 5 ( TRPC5 ) antagonist (WO2020061162, compound 100). Evifacotrep can be used for the research of neurological diseases. | |||
T83701 | TRPV1-Tat TFA | Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat | |
TRPV1-Tat, a peptide antagonist targeting transient receptor potential vanilloid 1 (TRPV1), is composed of amino acids 736-745 derived from TRPV1's A-kinase anchor protein (AKAP)-binding domain, combined with the HIV Tat... | |||
T6977 | SB-366791 | SB366791 | TRP/TRPV Channel |
SB-366791 is a new and selective cinnamide TRPV1 antagonist. | |||
T2298 | ML204 | TRP/TRPV Channel | |
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. | |||
T22124 | Oleoyl Serotonin | TRP/TRPV Channel | |
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM. | |||
T6848 | GSK1016790A | GSK101 | Calcium Channel , TRP/TRPV Channel |
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells. | |||
T1814 | ICILIN | AG-3-5 | TRP/TRPV Channel |
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist. | |||
T6617 | Optovin | TRP/TRPV Channel | |
Optovin is a TRPA1 activator, which is reversibly photoactivated. | |||
T10537 | BI-749327 | TRP/TRPV Channel | |
BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6). | |||
T5698 | TRPM8 antagonist 2 | TRP/TRPV Channel | |
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. | |||
T5640 | GSK2193874 | TRP/TRPV Channel | |
GSK2193874 was identified as a selective, orally active TRPV4 blocker. | |||
T12941 | SN 2 | TRP/TRPV Channel | |
SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM). | |||
T4680 | HC-067047 | HC067047 | TRP/TRPV Channel |
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH . | |||
T10300 | AMG2850 | TRP/TRPV Channel | |
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8). | |||
T16763 | RN-1747 | TRP/TRPV Channel | |
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively). RN-1747 also antagonizes TRPM8 (IC50: 4 μM... | |||
T6660 | SB-705498 | TRP/TRPV Channel | |
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. | |||
T7430 | AM-0902 | TRP/TRPV Channel | |
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1). | |||
T15628 | JT010 | TRP/TRPV Channel | |
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM). | |||
T9709 | TRPM8 antagonist 3 | TRP/TRPV Channel | |
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM). | |||
T8410 | ASP7663 | TRP/TRPV Channel | |
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. | |||
T9776 | TRPM4 inhibitor 8 | TRP/TRPV Channel | |
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. | |||
T5479 | AMG 333 | AMG-333 | TRP/TRPV Channel |
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine. | |||
T7526 | JNJ-17203212 | TRP/TRPV Channel | |
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). | |||
T4385 | PF-4840154 | TRP/TRPV Channel | |
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. | |||
T2007 | RQ-00203078 | TRP/TRPV Channel | |
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. | |||
T22360 | MDR-652 | TRP/TRPV Channel | |
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... | |||
T22537 | 9-Phenanthrol | TRP/TRPV Channel | |
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. | |||
T16532 | Pico145 | HC-608 | TRP/TRPV Channel |
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, T... | |||
T21543 | AP 18 | TRP/TRPV Channel | |
T16686 | Pyr10 | TRP/TRPV Channel | |
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... | |||
T12849 | SAR7334 | TRCP6-IN-1 | TRP/TRPV Channel |
T8581 | Flecainide hydrochloride | Others | |
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. | |||
T1822 | Clemizole | HCV Protease , Histamine Receptor | |
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. | |||
T24477 | MK6-83 | MK683 | TRP/TRPV Channel |
MK6-83 is the transient receptor potential channel ML3 agonist. | |||
T19723 | AMTB hydrochloride | AMTB | TRP/TRPV Channel |
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl... | |||
T7102 | BCTC | TRP/TRPV Channel | |
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively) | |||
T16483 | PF-05105679 | TRP/TRPV Channel | |
PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain. | |||
T10952 | Dabuzalgron | Ro 115-1240 | Apoptosis , Adrenergic Receptor |
Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial functi... | |||
T11394 | GFB-8438 | TRP/TRPV Channel | |
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). | |||
T8528 | AC1903 | TRP/TRPV Channel | |
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. | |||
T23322 | SB 452533 | TRP/TRPV Channel | |
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). | |||
T7191 | Diphenyleneiodonium chloride | DPI | NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel |
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. | |||
T16014 | Mavatrep | JNJ-39439335 | TRP/TRPV Channel |
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. | |||
T5827 | BI-6C9 | Apoptosis , Others , Mitochondrial Metabolism | |
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. | |||
T1822L | Clemizole hydrochloride | HCV Protease , Histamine Receptor | |
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. | |||
T2711 | Chembridge-5861528 | TCS 5861528 | TRP/TRPV Channel |
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively. | |||
T12306 | OMDM-5 | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel | |
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). | |||
T7205 | A-967079 | TRP/TRPV Channel | |
A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively. | |||
T21623 | AS1269574 | AS 1269574 | GPR , TRP/TRPV Channel |
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes. | |||
T7572 | RN-1734 | TRP/TRPV Channel | |
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively) |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T7177 | Capsazepine | Apoptosis , TRP/TRPV Channel | |
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ... | |||
T12514 | Podocarpic acid | Others , TRP/TRPV Channel | |
Podocarpic acid is a natural product and a novel TRPA1 activator. | |||
T6S1684 | 8-Gingerol | Antioxidant , Antibacterial , TRP/TRPV Channel | |
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... | |||
T2807 | Caffeic Acid | Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel | |
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. | |||
TN4417 | Larixyl acetate | Others | |
Larixyl acetate is a bioactive chemical. | |||
TQ0001 | 1,4-Cineole | Isocineole | Endogenous Metabolite , TRP/TRPV Channel |
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. | |||
T3S0081 | Oxypeucedanin | (+-)-Oxypeucedanin,Oxypeucadanin | Potassium Channel |
1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke... | |||
T3727 | Methyl syringate | Syringic Acid Methyl Ester | TRP/TRPV Channel |
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... | |||
TCS0102 | Pulegone | (+)-Pulegone | Calcium Channel , Endogenous Metabolite , TRP/TRPV Channel |
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... | |||
T2952 | Camphor | (±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa | Influenza Virus , TRP/TRPV Channel |
Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. | |||
TN1465 | Cannabigerol | NOS , 5-HT Receptor , ROS | |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... | |||
TN1377 | α-Spinasterol | alpha-Spinasterol | COX , Antibacterial , TRP/TRPV Channel |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v... | |||
T1407 | (-)-Menthol | L-Menthol,Levomenthol,Menthomenthol,Menthacamphor | Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel |
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo... | |||
T8307 | Hydroxy-α-sanshool | Hydroxy-α-sanshool | Endogenous Metabolite , TRP/TRPV Channel |
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM). | |||
T2845 | Imperatorin | Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen | TRP/TRPV Channel , AChR , AChE , NOD |
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. | |||
T23107 | Ononetin | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone | TRP/TRPV Channel |
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). | |||
T3865 | Beta-Eudesmol | Beta-Selinenol | TRP/TRPV Channel , AChR |
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica... | |||
T2994 | (E)-Cardamonin | Alpinetin chalcone,Cardamomin,Cardamonin,(E)-Cardamoni | Apoptosis , TRP/TRPV Channel |
(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM... | |||
T1321 | Nonivamide | Nonanoic acid vanillylamide,Pelargonic acid vanillylamide,Vanillyl-N-nonylamide,Pseudocapsaicin | TRP/TRPV Channel |
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an ... | |||
T0851 | Pregnenolone | 3β-Hydroxy-5-pregnen-20-one,Arthenolone | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel , AChR , Autophagy |
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
T14046 | Anandamide | (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | Cannabinoid Receptor , Endogenous Metabolite |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... | |||
T4S0790 | Diosbulbin B | Others | |
1. Diosbulbin B exhibits potential hepatotoxicity. 2. Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time. | |||
TN1055 | Licochalcone E | TNF , Liver X Receptor , PPAR | |
Licochalcone E is a potential LXRβ agonist. | |||
T3903 | Angoroside C | Prostaglandin Receptor | |
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and ... | |||
TWS1229 | Aristolone | Aristofone | Others |
Aristolone (Aristofone) has potential anti-cancer activity. | |||
T7957 | 2-Isopropyl Thioxanthone | Others | |
2-Isopropyl Thioxanthone has potential anti-estrogenic and anti-androgenic properties. | |||
T4S1876 | 3-Deoxyaconitine | Sodium Channel | |
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele... | |||
T2883 | Syringic acid | 3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,NSC 2129 | Others , Endogenous Metabolite , Antibacterial |
Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hypergl... | |||
T39836 | Monoethyl phthalate | ||
Monoethyl phthalate is a metabolite of diethyl phthalate, serving as a urinary biomarker for phthalate exposure, and indicating potential risks of thyroid cancer and benign nodules. | |||
T8009 | 1-Furfurylpyrrole | 1-Furfurylpyrrole | Others |
1-Furfurylpyrrole is a potential contributor of flavor and aroma to popcorn. | |||
T13355 | Xanthorrhizol | Antibacterial | |
Xanthorrhizol is a natural product isolated from Curcuma xanthorrhiza Roxb, is an agent of potential antibacterial. | |||
TMA2474 | δ-Tocotrienol | Delta-Tocotrienol | ERK , BCL , VEGFR , Akt , PI3K , PDK , p53 |
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSC-LC) cell proliferation, induce apoptosis... | |||
TN2054 | Periplocymarin | Calcium Channel | |
Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca. | |||
T3902 | Atractylenolide III | ICodonolactone,8β-Hydroxyasterolide | Apoptosis |
Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung... | |||
T3S1265 | Liriopesides B | Nolinospiroside F | Others |
Liriopesides B (Nolinospiroside F) exhibited potential anticancer activity against human ovarian cancer A2780 cells. | |||
T19398 | L-Octanoylcarnitine | Endogenous Metabolite | |
L-Octanoylcarnitine is the active octanoylcarnitine present in plasma and is a potential biomarker for breast cancer. | |||
T3378 | Alpha-Estradiol | Alfatradiol,17α-Estradiol,Epiestrol,Epiestradiol | Estrogen/progestogen Receptor , Reductase , Endogenous Metabolite |
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia. | |||
TN7025 | Canolol | Phenol, 4-ethenyl-2,6-dimethoxy- | COX |
Canolol (Phenol, 4-ethenyl-2,6-dimethoxy-) is an antioxidant phenolic compound that has potential use as a COX-2 inhibitor. | |||
TN7250 | Torachrysone Triglucoside | 1-[8-[(O-β-D-Glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]-1-hydroxy-6-methoxy-3-methyl-2-naphthalenyl]ethanone | Others |
Torachrysone Triglucoside is a glucoside isolated from cassia seeds with potential antitumor activity. | |||
T4957 | Carnosic acid | Apoptosis , ROS , Antibacterial | |
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties. | |||
TN4662 | Nonanal | Others | |
Nonanal is a growth factor for wood-rotting fungi. Nonanal is a potential attractant for the pine shoot beetle. | |||
T4S0398 | Rosin | p38 MAPK | |
Rosin is a natural product,may have therapeutic potential for the treatment of inflammation | |||
TN1530 | Cowaxanthone B | Antioxidant , Parasite | |
Cowaxanthone B is a new tetraoxoanthrone isolated from the fruit of Garcinia cambogia.Cowaxanthone B has potential antibacterial activity. | |||
T6S2146 | Epimedin B | Epmedin B | Others |
1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts. | |||
T3S2296 | Gardenoside | Others | |
Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB act... | |||
T2978 | Mogroside V | AMPK | |
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce... | |||
T5778 | 5,7-DIMETHOXYFLAVONE | Anti-infection , P450 | |
5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential. | |||
T5788 | XYLOBIOSE | IL Receptor , TNF | |
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders. | |||
TN1513 | Clitorin | PKC , Antifection | |
Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential. | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-05030 | PCDH7 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cance... | |||
TMPY-04826 | LILRB5/CD85c Protein, Human, Recombinant (His) | Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) le... | |||
TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli |
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as... | |||
TMPK-00347 | Serum Albumin Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Human serum albumin (HSA), the most prominent protein in plasma, binds different classes of ligands at multiple sites. HSA provides a depot for many compounds, affects pharmacokinetics of many drugs, holds some ligands i... | |||
TMPY-00566 | CCL18 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its... | |||
TMPY-00545 | Dermcidin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia... | |||
TMPY-00476 | ITGB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involv... | |||
TMPY-02258 | Kallikrein 3/KLK3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that i... | |||
TMPY-01280 | FOLR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant ... | |||
TMPY-02030 | CD82 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras... | |||
TMPY-04544 | MEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/... | |||
TMPY-01813 | ACRV1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Acrosomal protein SP-1, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the a... | |||
TMPY-02219 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) | H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N... | |||
TMPY-04022 | BOLA1 Protein, Human, Recombinant (His) | Human | E. coli |
BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential. Furthermore, overexpression of BOLA... | |||
TMPK-01485 | HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic fe... | |||
TMPK-00127 | CLEC4A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. silencing of Clec4a2 expression via skin delivery of shRNA produces an effe... | |||
TMPK-00126 | CLEC4A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. silencing of Clec4a2 expression via skin delivery of shRNA produces an effe... | |||
TMPK-00871 | DSG3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
To identify genes that could potentially serve as molecular therapeutic markers for human head and neck cancer (HNC),DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopatho... | |||
TMPY-00510 | FKBP11 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
FKBP11 serve as biomarker and/or therapeutic target for Acute aortic dissection (AAD). FKBP11 during the development of HCC and FKBP11 has the potential to be an early marker for HCC. | |||
TMPK-00726 | DSG3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
To identify genes that could potentially serve as molecular therapeutic markers for human head and neck cancer (HNC),DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopatho... | |||
TMPJ-00666 | CLIC2 Protein, Human, Recombinant (His) | Human | E. coli |
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane in... | |||
TMPH-03231 | AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) | Raphanus sativus | E. coli |
Possesses antifungal activity sensitive to inorganic cations. Induces potential changes in fungal membranes and increased K(+) efflux and Ca(2+) uptake. AFP2 Protein, Raphanus sativus, Recombinant (His & SUMO) is express... | |||
TMPK-00994 | FNDC1 Protein, Human, Recombinant (His) | Human | E. coli |
Fibronectin type III domain‑containing protein 1 (FNDC1) is a protein that contains a major component of the structural domain of fibronectin.FNDC1 was highly upregulated and acted as an oncogene in BC. Therefore, target... | |||
TMPJ-01364 | LMCD1 Protein, Human, Recombinant (His) | Human | E. coli |
LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a ... | |||
TMPK-00077 | EPO/Erythropoietin Protein, Human, Recombinant | Human | HEK293 Cells |
Erythropoietin (EPO) is a circulating hormone conventionally considered to be responsible for erythropoiesis. In addition to facilitating red blood cell production, EPO has pluripotent potential, such as for cognition im... | |||
TMPY-03795 | EIF5A2 Protein, Human, Recombinant (His) | Human | E. coli |
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i... | |||
TMPY-02660 | Resistin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Resistin is an adipocytokine, which has been studied for its role in insulin resistance and recently in inflammation. The RETN and CAP1 polymorphisms and gene expression may be potential biomarkers for breast cancer risk... | |||
TMPK-00481 | PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity ... | |||
TMPK-01517 | HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg... | |||
TMPK-01480 | HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg... | |||
TMPK-00553 | ADAM9 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. ADAM9 may be a prognostic marker for vestibu... | |||
TMPY-01555 | PRAC Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
The PRAC gene is located on chromosome 17 at position 17q21, about 4 kbp downstream from the homeodomain Hoxb-13 gene. The pathogenesis of PCa may be due to the expression levels of PRAC protein, and this protein can ser... | |||
TMPK-01308 | TAG-72 Protein, Canine, Recombinant (His) | Canine | E. coli |
The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA... | |||
TMPK-01516 | HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upreg... | |||
TMPY-04764 | PCK2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabol... | |||
TMPK-00479 | AGER Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical ... | |||
TMPK-01042 | FcRH6/FCRL6 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed... | |||
TMPK-00708 | TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing norma... | |||
TMPY-04249 | Syndecan-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde... | |||
TMPY-05168 | Syndecan-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Synde... | |||
TMPJ-00157 | CD82 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemoki... | |||
TMPK-01040 | NKG2C/CD159c Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role i... | |||
TMPH-00735 | LuxS Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in respon... | |||
TMPK-00592 | Latexin Protein, Human, Recombinant (His) | Human | E. coli |
Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the late... | |||
TMPK-00759 | IgG1 Fc Protein, Human, Recombinant | Human | HEK293 Cells |
IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflam... | |||
TMPK-00001 | CD24 Protein-VLP, Human, Recombinant | Human | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00004 | CD24 Protein, Human, Recombinant (GST) | Human | E. coli |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00674 | CD24 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
TMPK-00224 | BTN3A2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
BTN3A2/BT3.2 butyrophilin mRNA expression by tumoral cells was previously identified as a prognostic factor in a small cohort of high grade serous epithelial ovarian cancer (HG-EOC).In conclusion, BT3.2 protein is a pote... | |||
TMPK-01318 | CD24 Protein-VLP, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells |
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential fo... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L9410 | Covalent Inhibitor Library | 1920 compounds | |
A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. | |||
L7870 | Carboxylic Acid Fragment Library With Solubility | 1806 compounds | |
L9810 | Anti-Fibrosis Compound Library | 1180 compounds | |
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS; | |||
L4700 | Immunology/Inflammation Compound Library | 4720 compounds | |
A unique collection of 4720 anti-inflammation compounds effective for high throughput screening and high content screening. | |||
L6010 | Natural Product Library | 3840 compounds | |
A unique collection of 3840 natural products for high throughput screening (HTS) and high content screening (HCS); | |||
L3900 | DNA Damage & Repair Compound Library | 910 compounds | |
A unique collection of 910 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L6100 | Polyphenolic Natural Product Library | 635 compounds | |
A unique collection of 635 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L3980 | DNA Damage and Repair Compound Library Plus | 667 compounds | |
Well-chosen 667 compounds with unique structures targeting DNA damage & repair; | |||
L7800 | High Solubility Fragment Library | 2728 compounds | |
Structurally diverse, medicinally active, and unique chemistry (strong IP potential); | |||
L2300 | Ion Channel Inhibitor Library | 931 compounds | |
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery; | |||
L1200 | Epigenetics Compound Library | 953 compounds | |
Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L8600 | Ubiquitination Compound Library | 210 compounds | |
A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L8110 | Reprogramming Compound Library | 1813 compounds | |
A unique collection of 1813 reprogramming signaling pathway-related bioactive small molecule compounds for high-throughput, high-content screening. | |||
L1120 | AMPK-Targeted Compound Library | 80 compounds | |
80 well-chosen unique AMPK-targeted small molecules; | |||
L8000 | Stem Cell Differentiation Compound Library | 1197 compounds | |
A unique collection of 1197 stem cell differentiation signaling targeted compounds for high throughput and high content screening; | |||
L9860 | Antidepressant Compound Library | 1163 compounds | |
1163 compounds associated with depression that can be used for high-throughput and high-content screening | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L1710 | Anti-COVID-19 Compound Library | 1133 compounds | |
A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents; | |||
L2140 | Cancer Cell Differentiation Compound Library | 406 compounds | |
A unique collection of 406 cancer cell differentiation inducing compounds for high throughput and high content screening; | |||
L1300 | PI3K-AKT-mTOR Compound Library | 420 compounds | |
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; | |||
L6700 | Anti-Tumor Natural Product Library | 1772 compounds | |
A unique collection of 1772 natural products with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS); | |||
L7200 | Calcium Channel Compound Library | 140 compounds | |
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening; | |||
L9500 | Target-Focused Phenotypic Screening Library | 1796 compounds | |
A unique collection of 1796 annotated bioactive compounds with clear targets, suitable for phenotypic screening; | |||
L6820 | Tobacco Monomer Library | 747 compounds | |
L6400 | Marine Natural Product Library | 144 compounds | |
A unique collection of 144 marine natural products for high throughput screening (HTS) and high content screening (HCS); | |||
L5300 | Mitochondria-Targeted Compound Library | 812 compounds | |
A unique collection of 812 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; | |||
L2570 | Human Metabolite Library | 4454 compounds | |
A unique collection of 4454 human metabolites for high-throughput, high-content screening. | |||
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; | |||
L6210 | Tibetan medicine Compound Library | 747 compounds | |
A collection of 747 natural product molecules originated from Tibetan medicine, which can be used for high-throughput and high-content screening. | |||
L2196 | Anti-Ovarian Cancer Compound Library | 1867 compounds | |
DO1200 | SmartTM Library | 53200 compounds | |