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Search Results for " cholesterol "

285

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108

天然化合物

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カタログ番号	製品名	別名	ターゲット
T41008	BODIPY-Cholesterol	BCh2
	BODIPY-Cholesterol (TF-Chol) is a cholesterol analog with a fluorescent BODIPY motif and cellular permeability, and is a novel BODIPY cholesterol probe.BODIPY-Cholesterol can be used to study intracellular sterol uptake ...
T35973	Cholesterol-5α,6α-epoxide	Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE applicat...		Others
T35977	6α-hydroxy Cholesterol	6α-hydroxy Cholesterol,6α-OHC
	6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1]
T36130	22(S)-hydroxy Cholesterol	22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatoc...
T60796	Cholesterol 24-hydroxylase-IN-1		P450
	Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.Cholesterol 24-hydroxylase-IN-1 may be useful in ...		P450
T36998	7β,27-dihydroxy Cholesterol	7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res...
T67509	Cholesteryl Hemisuccinate	Cholesterol hydrogen succinate	Apoptosis , DNA/RNA Synthesis , Topoisomerase
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl ...		Apoptosis , DNA/RNA Synthesis , Topoisomerase
T36217	19-hydroxy Cholesterol
	19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.[1]
T40140	Zanamivir-Cholesterol Conjugate
	Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in respons...
T65554	cholesterol-absorption inhibitor Intermediate 2		Others
	cholesterol-absorption inhibitor Intermediate 2 is a potent and orally active cholesterol absorption inhibitor that reduces blood cholesterol levels.		Others
T21530	4β-hydroxy Cholesterol
	4β-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4.
T35236	5α-Hydroxy-6-keto cholesterol	YS 64,Yakkasterone
	Yakkasterone is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone.
T77231	Cholesterol nervonate
	Cholesterol nervonate, a biochemical reagent, serves as both a biological material and an organic compound in life science research.
T76139	Cholesterol esterase
	Cholesterol esterase, also known as bile salt-stimulated lipase and carboxyl ester lipase, is an enzyme responsible for hydrolyzing cholesterol ester into cholesterol and free fatty acid within the intestinal lumen. This...
T76128	Cholesterol oxidase
	Cholesterol oxidase (ChOx), a bacterial flavin oxidase containing FAD utilized in biochemical research, catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and subsequent...
T65073	Cholesterol n-Octanoate
	Cholesterol n-Octanoate is a useful organic compound for research related to life sciences. The catalog number is T65073 and the CAS number is 1182-42-9.
T35941	DC-Chol hydrochloride	Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate	Beta Amyloid
	DC-Chol hydrochloride(DC-Cholesterol hydrochloride) inhibited the formation of Aβ40 fibrils under appropriate experimental conditions and significantly inhibited amyloid formation from oxidized hCT in a dose-dependent ma...		Beta Amyloid
T38056	Cholesteryl Arachidate	Cholesterol Arachidate
	Cholesteryl arachidate is a cholesterol ester that has been found in human meibum.[1][2] It has been used as an internal standard for the quantification of fatty acids in B. napus.[3]
T77270	Cholesterol-PEG-Folate (MW 2000)
	Cholesterol-PEG-Folate (MW 2000), an excipient, facilitates the preparation of folate-conjugated PEG-liposomes [1].
T82731	Cholesterol 24-hydroxylase-IN-2
	Cholesterol 24-hydroxylase-IN-2 is a potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), exhibiting an IC50 value of 5.4 nM, and has potential applications in mammalian imaging of this enzyme [1].
T35321	Zymostenol	delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol	Endogenous Metabolite , ROR
	Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.		Endogenous Metabolite , ROR
T14933	Cetaben		Others
	Cetaben is a PPARα-independent peroxisome proliferator and is a non-fibrate hypolipidemic drug. It potent reduces the concentration of cholesterol and triglycerides.		Others
T14362	AY 9944		Others
	AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomera...		Others
T7482	3-chloro-5-hydroxybenzoic Acid		GPR
	3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)		GPR
T4039	BIBB 515		Others
	BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...		Others
T4524	SBC-110736	SBC110736	Others , Serine/threonin kinase
	SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor		Others , Serine/threonin kinase
T27478	GSK3987		Liver X Receptor
	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.		Liver X Receptor
T3283	Cetilistat	ATL-962	Lipid
	Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.		Lipid
T23521	VULM 1457		Acyltransferase
	VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...		Acyltransferase
T6048	Dalcetrapib	JTT-705,RO4607381	CETP
	Dalcetrapib (RO4607381), a rhCETP inhibitor (IC50=0.2 μM), increases the plasma HDL cholesterol.		CETP
T23550	YM-750	YM 750	Acyltransferase
	YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest...		Acyltransferase
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T8937	Soticlestat	TAK-935,OV935	P450
	Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research.		P450
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
T38996	4α-Methylcholesterol
	4α-Methylcholesterol, a derivative of Cholesterol, possesses the ability to oxidize 3-hydroxy steroid at an apparent K m of 12.6 μM.
T71756	24(S),25-Epoxycholesterol
	24(S),25-Epoxycholesterol is an oxysterol agonist of the liver X receptor.
T77264	Thiocholesterol
	Thiocholesterol, a cholesteric liquid crystal (CLC), functions as a robust stabilizer for silver nanoparticles (SNPs) and plays a significant role in the synthesis of cationic lipids. Its applications extend to plasma me...
T67835	LKM38
	LKM38, a novel diazolidinyl cholesterol probe, is a promising cholesterol mimetic.LKM38 both maintains cholesterol-resistant cell growth and appropriately regulates key cholesterol homeostatic pathways.LKM38 can be a pow...
T28882	Sultosilic acid, piperazine salt	A-585,Mimedran,piperazine-sultosylate,A585,A 585
	Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically signif...
T19239	Cicloxilic acid	Cycloxilic acid	Others
	Cicloxilic acid（Cycloxilic acid） has choleretic activity and inhibits biliary cholesterol output.		Others
T1593	Ezetimibe	SCH 58235	Others , Nrf2 , NPC1L1 , Autophagy
	Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.		Others , Nrf2 , NPC1L1 , Autophagy
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
T25276	Crilvastatin	PMD387,PMD 387,PMD-387	HMG-CoA Reductase
	Crilvastatin (PMD 387) is a novel non-competitive hydroxymethylglutaryl coenzyme A reductase inhibitor with cholesterol-lowering activity that inhibits cholesterol uptake in rats with hereditary hypercholesterolemia.		HMG-CoA Reductase
T68042	CHF-4227	Chf4227,Chf 4227	Estrogen Receptor/ERR
	CHF-4227 is a novel, potent and selective estrogen receptor modulator that reduces cholesterol and LDL cholesterol concentrations.		Estrogen Receptor/ERR
T19861	Niceritrol	Perycit,Cardiolipol,Bufor	Others
	Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions.		Others
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP

Compounds

Cholesterol-5α,6α-epoxide

T35973

Synonym: Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176

Target: Others

6α-hydroxy Cholesterol

T35977

Synonym: 6α-hydroxy Cholesterol,6α-OHC

Target:

22(S)-hydroxy Cholesterol

T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Target:

Cholesterol 24-hydroxylase-IN-1

T60796

Synonym:

Target: P450

7β,27-dihydroxy Cholesterol

T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

Target:

Cholesteryl Hemisuccinate

T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

19-hydroxy Cholesterol

T36217

Synonym:

Target:

Zanamivir-Cholesterol Conjugate

T40140

Synonym:

Target:

Cholesterol β-D-Glucoside

T38045

Synonym:

Target:

cholesterol-absorption inhibitor Intermediate 2

T65554

Synonym:

Target: Others

4β-hydroxy Cholesterol

T21530

Synonym:

Target:

5α-Hydroxy-6-keto cholesterol

T35236

Synonym: YS 64,Yakkasterone

Target:

Cholesterol nervonate

T77231

Synonym:

Target:

Cholesterol esterase

T76139

Synonym:

Target:

Cholesterol oxidase

T76128

Synonym:

Target:

Cholesterol n-Octanoate

T65073

Synonym:

Target:

DC-Chol hydrochloride

T35941

Synonym: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

Target: Beta Amyloid

Cholesteryl Arachidate

T38056

Synonym: Cholesterol Arachidate

Target:

Cholesterol-PEG-Folate (MW 2000)

T77270

Synonym:

Target:

Cholesterol 24-hydroxylase-IN-2

Synonym: delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol

Target: Endogenous Metabolite, ROR

3-chloro-5-hydroxybenzoic Acid

Target: Others, Serine/threonin kinase

GSK3987

T27478

Synonym:

Target: Liver X Receptor

Target: Acyltransferase

Dalcetrapib

T6048

Synonym: JTT-705,RO4607381

Target: Acyltransferase

Triparanol

T26296

Synonym: MER-29,NSC 65345,NSC-65345,NSC65345

Target: Apoptosis, Hedgehog/Smoothened

Synonym: TAK-935,OV935

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Mitotane

T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD

Target: Apoptosis, AChR

Rosuvastatin calcium

T1510

Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

24(S),25-Epoxycholesterol

Sultosilic acid, piperazine salt

T28882

Synonym: A-585,Mimedran,piperazine-sultosylate,A585,A 585

Target:

Cicloxilic acid

T19239

Synonym: Cycloxilic acid

Target: Others, Nrf2, NPC1L1, Autophagy

Synonym: PMD387,PMD 387,PMD-387

Target: HMG-CoA Reductase

CHF-4227

T68042

Synonym: Chf4227,Chf 4227

Target: Estrogen Receptor/ERR

Niceritrol

T19861

Synonym: Perycit,Cardiolipol,Bufor

カタログ番号	製品名	別名	ターゲット
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...		Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
T8040	Cholesterol myristate	Cholesteryl myristate,Cholesteryl tetradecanoate	Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
	Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i...
T10805	Cholesterol glucuronide		Others
	Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver.		Others
T2918	Cholesteryl Acetate	Cholesterin acetate,Cholesterol acetate,Acebrochol	Others
	Cholesteryl Acetate is a cholesterol ester obtained from the esterification of the hydroxyl group of cholesterol with acetic acid. It functions as a metabolite in the human body and is both a cholesterol ester and an ace...		Others
TQ0274	27-Hydroxycholesterol	25(R)-27-hydroxy Cholesterol	Estrogen/progestogen Receptor , Liver X Receptor
			Estrogen/progestogen Receptor , Liver X Receptor
T19237	Cholesteryl oleate	Oleoylcholesterol,Cholesterol Oleate,Cholesteryl cis-9-octadecenoate	Endogenous Metabolite
	Cholesteryl oleate (Cholesteryl cis-9-octadecenoate) is a cholesteryl ester. Cholesteryl oleate can be used to synthesize solid lipid nanoparticles which is a nanoparticle-based gene therapy approach.		Endogenous Metabolite
T5239	Cholesteryl sulfate sodium	Cholesterol 3-Sulfate Sodium Salt,Sodium Cholesteryl Sulfate	Endogenous Metabolite , PKC
	Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a regulatory function. Cholesteryl sulfate sodium also activ...		Endogenous Metabolite , PKC
T5214	Cholesteryl linoleate	CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester	Others , Endogenous Metabolite
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...		Others , Endogenous Metabolite
T19236	Cholesteryl behenate	Cholesteryl docosanoate,Cholesterol behenate	Others
	Cholesteryl behenate is a standard in electrospray ionization tandem mass spectrometry for the analysis of cholesteryl esters and cholesterol.		Others
T2721	Digitonin		Others
	Digitonin is a natural product of the glycoside family and is a detergent. Digitonin has antitumor activity, binds to cholesterol molecules to increase the permeability of cell membranes, and is active in the cleavage of...		Others
T8192	Pentacosanoic acid		Others , Endogenous Metabolite
	Pentacosanoic acid, belongs to the class of organic compounds known as very long-chain fatty acids.		Others , Endogenous Metabolite
TN1576	Diallyl disulfide		IL Receptor , NOS , NF-κB
	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.		IL Receptor , NOS , NF-κB
T8153	Glycohyodeoxycholic acid		Others , Endogenous Metabolite
	glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.		Others , Endogenous Metabolite
T19161	7α-Hydroxycholesterol		Others
	7α-Hydroxycholesterol is a cholesterol oxide formed by both enzymatic and non-enzymatic oxidation. It can be used as a biomarker for lipid peroxidation.		Others
TN6715	7-Ketocholesterol		Others
	7-Ketocholesterol is a metabolite of Cholesterol		Others
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
T2963	Cholic Acid	Cholanic acid,Cholate,Colalin	Endogenous Metabolite
	Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.		Endogenous Metabolite
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
TMS2180	Zeaxanthin	Anchovyxanthin,All-Trans-Zeaxanthin	Antioxidant , Endogenous Metabolite
	1. Lutein and Zeaxanthin (All-Trans-Zeaxanthin) in neural tissue may have biological effects that include antioxidation, anti-inflammation, and structural actions. 2. Lutein and Zeaxanthin may be protective against eye d...		Antioxidant , Endogenous Metabolite
T4537	Cholic acid sodium	SodiumCholate	HIV Protease , Endogenous Metabolite
	Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.		HIV Protease , Endogenous Metabolite
T2744	Methyl Cholate	Cholic acid methyl ester	Others
	Methyl Cholate (Cholic acid methyl ester) is the methyl form of cholic acid. Cholic acid is a major bile acid produced by the liver and synthesized from cholesterol.		Others
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T13522	7-Ketolithocholic acid	3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite
	7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholester...		Endogenous Metabolite
T4970	LANOSTEROL	3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.		Endogenous Metabolite
TN6714	Geranylgeraniol	FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095	Apoptosis
	Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ...		Apoptosis
T4717	25-Hydroxycholesterol		Others , Endogenous Metabolite , HMG-CoA Reductase
	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...		Others , Endogenous Metabolite , HMG-CoA Reductase
T4923	7-Dehydrocholesterol	Provitamin D3,7-DHC	Endogenous Metabolite
	7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.		Endogenous Metabolite
T10085	20(S)-Hydroxycholesterol	20α-Hydroxycholesterol	Smo
	20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo).		Smo
T10086	24-Hydroxycholesterol	Cholest-5-ene-3beta,24-diol	Liver X Receptor , NMDAR
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcription factor LXR, which has been used in the study of cardioge...		Liver X Receptor , NMDAR
T29329	24-Methylenecholesterol	24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,Ostreasterol	Acyltransferase
	24-Methylenecholesterol (24 Methylenecholesterol) is a natural marine sterol, which stimulates cholesterol acyl transferase (ACAT) in human macrophages.		Acyltransferase
T14063	7α,25-Dihydroxycholesterol	7α,25-OHC	EBI2/GPR183 , Endogenous Metabolite
			EBI2/GPR183 , Endogenous Metabolite
T75515	7β,25-Dihydroxycholesterol
	7β,25-Dihydroxycholesterol, an endogenous metabolite, functions as chemoattractants for immune cells that express EBI2 [1].
TN1338	7Beta-Hydroxycholesterol		LDL , Calcium Channel , MAPK
	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.		LDL , Calcium Channel , MAPK
T19164	8-Dehydrocholesterol		Others
	8-Dehydrocholesterol is a compound whose elevated concentration is a diagnostic biochemical hallmark of classical Smith-Lemli-Opitz syndrome.		Others
T15720	Lathosterol		Endogenous Metabolite
	Lathosterol, a molecule akin to cholesterol, serves as a biomarker for the body's total cholesterol synthesis, as indicated by its serum concentration.		Endogenous Metabolite
TN1474	Caulilexin C		Others , Antifungal
	Caulilexin C shows inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 mug/ml.		Others , Antifungal
T21383	D-Thyroxine	Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine	Others
	D-Thyroxine (Dextroxin) could lower cholesterol and also increases hepatic lipase which in turn improves utilization of triglycerides, leading to improve apolipoprotein E cholesterol particles.		Others
T5074	Cholesteryl palmitate		Others , Endogenous Metabolite
	Cholesteryl palmitic acid is a cholesteryl ester. A cholesteryl ester is an ester of cholesterol. Fatty acid esters of cholesterol constitute about two-thirds of the cholesterol in the plasma. Cholesterol is a sterol (a ...		Others , Endogenous Metabolite
T5238	1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine	1,2-Dipalmitoyl-sn-glycero-3-PE,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE	Others , Endogenous Metabolite
	1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), a phospholipid member of the glycerophosphonoethanolamine family, is a major component in biological membranes. Studies focused on interactions between DPPE and ch...		Others , Endogenous Metabolite
T1207	Lovastatin	MK-803,Mevinolin	Ferroptosis , HMG-CoA Reductase , Autophagy
	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.		Ferroptosis , HMG-CoA Reductase , Autophagy
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
T4S2157	Campesterol	(24R)-5-Ergosten-3β-ol	Endogenous Metabolite
	Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e...		Endogenous Metabolite
T19711	Desmosterol	Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite
	Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.		Endogenous Metabolite
T2962	5α-Cholestan-3β-ol	Dihydrocholesterol,Zymostanol,5α-Cholestanol,5alpha-Cholestanol,NSC 18188,Beta-Cholestanol	Others , Endogenous Metabolite
	5α-Cholestan-3β-ol (NSC 18188) is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter.		Others , Endogenous Metabolite
T8165	Erythrodiol		Endogenous Metabolite , ABC
	Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.		Endogenous Metabolite , ABC
T5544	2-Furoic acid	Furan-2-carboxylic acid	Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T0254	Probucol	DH-581	Virus Protease , ABC , Lipid
	Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.		Virus Protease , ABC , Lipid
T1664	Meglutol	Dicrotalic acid,3-Hydroxy-3-methylglutaric acid	Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...		Endogenous Metabolite , HMG-CoA Reductase , Autophagy
T37997	Murideoxycholic Acid
	Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prev...
T5240	Cholestenone	(+)-4-Cholesten-3-one	Others , Endogenous Metabolite
	Cholestenone ((+)-4-Cholesten-3-one) is an intestinal metabolite of Cholesterol. It shows an anti-obesity effect on animals.		Others , Endogenous Metabolite
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天然物製品

Cholesterol

T0760

Synonym: Cholesterin,Cholesteryl alcohol

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Cholesterol myristate

T8040

Synonym: Cholesteryl myristate,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Cholesterol glucuronide

Synonym: Cholesterin acetate,Cholesterol acetate,Acebrochol

Target: Others

27-Hydroxycholesterol

TQ0274

Synonym: 25(R)-27-hydroxy Cholesterol

Target: Estrogen/progestogen Receptor, Liver X Receptor

Cholesteryl oleate

T19237

Synonym: Oleoylcholesterol,Cholesterol Oleate,Cholesteryl cis-9-octadecenoate

Target: Endogenous Metabolite

Cholesteryl sulfate sodium

T5239

Synonym: Cholesterol 3-Sulfate Sodium Salt,Sodium Cholesteryl Sulfate

Target: Endogenous Metabolite, PKC

Cholesteryl linoleate

T5214

Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester

Target: Others, Endogenous Metabolite

Cholesteryl behenate

T19236

Synonym: Cholesteryl docosanoate,Cholesterol behenate

Target: Others, Endogenous Metabolite

Diallyl disulfide

TN1576

Synonym:

Target: IL Receptor, NOS, NF-κB

glycohyodeoxycholic acid

T8153

Synonym:

Target: Others, Endogenous Metabolite

7α-Hydroxycholesterol

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Cholic Acid

T2963

Synonym: Cholanic acid,Cholate,Colalin

Target: Endogenous Metabolite

Pseudoprotodioscin

T5S0246

Synonym:

Target: Others, Fatty Acid Synthase

Zeaxanthin

TMS2180

Synonym: Anchovyxanthin,All-Trans-Zeaxanthin

Target: Antioxidant, Endogenous Metabolite

Cholic acid sodium

T4537

Synonym: SodiumCholate

Target: HIV Protease, Endogenous Metabolite

Methyl Cholate

T2744

Synonym: Cholic acid methyl ester

Target: Others

Simvastatin

T0687

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

7-Ketolithocholic acid

T13522

Synonym: 3α-Hydroxy-7-oxo-5β-cholanic acid

Target: Endogenous Metabolite

LANOSTEROL

T4970

Synonym: 3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Geranylgeraniol

TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095

Target: Apoptosis

25-Hydroxycholesterol

T4717

Synonym:

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

7-Dehydrocholesterol

T4923

Synonym: Provitamin D3,7-DHC

Target: Endogenous Metabolite

20(S)-Hydroxycholesterol

T10085

Synonym: 20α-Hydroxycholesterol

Target: Smo

24-Hydroxycholesterol

T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

24-Methylenecholesterol

T29329

Synonym: 24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,Ostreasterol

Target: Acyltransferase

7α,25-Dihydroxycholesterol

T14063

Synonym: 7α,25-OHC

Target: EBI2/GPR183, Endogenous Metabolite

7β,25-Dihydroxycholesterol

T75515

Synonym:

Target:

7Beta-Hydroxycholesterol

TN1338

Synonym:

Target: LDL, Calcium Channel, MAPK

Target: Endogenous Metabolite

Caulilexin C

TN1474

Synonym:

Target: Others, Antifungal

D-Thyroxine

T21383

Synonym: Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine

Target: Others

Cholesteryl palmitate

T5074

Synonym:

Target: Others, Endogenous Metabolite

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine

T5238

Synonym: 1,2-Dipalmitoyl-sn-glycero-3-PE,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE

Target: Others, Endogenous Metabolite

Lovastatin

T1207

Synonym: MK-803,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Methyl protodioscin

T3771

Synonym: Smilax saponin B,NSC-698790

Target: Apoptosis

Campesterol

T4S2157

Synonym: (24R)-5-Ergosten-3β-ol

Target: Endogenous Metabolite

Desmosterol

T19711

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

5α-Cholestan-3β-ol

T2962

Synonym: Dihydrocholesterol,Zymostanol,5α-Cholestanol,5alpha-Cholestanol,NSC 18188,Beta-Cholestanol

Target: Others, Endogenous Metabolite

Erythrodiol

T8165

Synonym:

Target: Endogenous Metabolite, ABC

2-Furoic acid

T5544

Synonym: Furan-2-carboxylic acid

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

Probucol

T0254

Synonym: DH-581

Target: Virus Protease, ABC, Lipid

Meglutol

T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Synonym: (+)-4-Cholesten-3-one

Target: Others, Endogenous Metabolite

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03605	CHOD Protein, Streptomyces sp., Recombinant (GST)	Streptomyces	E. coli
	Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product. CHOD Protein, Streptomyces sp., Recombinant (GST) is expresse...
TMPY-00055	LCAT Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradie...
TMPH-01084	CYP11A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	CYP11A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.1 kDa and the accession number is P05108.
TMPH-01186	CYP2C9 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00007	HMGCR Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ...
TMPY-02956	Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney...
TMPK-00835	LCAT Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol ...
TMPH-03593	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)	Streptococcus pneumoniae	E. coli
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertio...
TMPH-00225	APOA1 Protein, Bovine, Recombinant (His)	Bovine	P. pastoris (Yeast)
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). A...
TMPK-01291	ANXA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPH-02316	YJEFN3 Protein, Human, Recombinant	Human	E. coli
	May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endotheli...
TMPH-00224	APOA1 Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). A...
TMPH-03592	Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)	Streptococcus pneumoniae	P. pastoris (Yeast)
	A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertio...
TMPH-01623	GBA Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the tu...
TMPH-02476	HMGCR Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ...
TMPK-00799	ANXA1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-00768	ANXA1 Protein, Human, Recombinant (His)	Human	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPH-02842	CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit...
TMPH-01624	GBA Protein, Human, Recombinant	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the tu...
TMPY-04767	PMVK Protein, Human, Recombinant (His)	Human	E. coli
	PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level a...
TMPJ-00158	Apolipoprotein A-I/APOA1 Protein, Human, Recombinant	Human	E. coli
	Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various...
TMPH-00001	CD133/PROM1 Protein-VLP, Human, Recombinant (His)	Human	HEK293 Cells
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit...
TMPH-03323	LIPA Protein, Rat, Recombinant (His)	Rat	E. coli
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E....
TMPH-00831	PMP2 Protein, Horse, Recombinant (His & SUMO)	Horse	E. coli
	May play a role in lipid transport protein in Schwann cells. May bind cholesterol. PMP2 Protein, Horse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular we...
TMPJ-00756	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipo...
TMPH-00492	PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)	Canine	E. coli
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Ca...
TMPH-01603	Lanosterol synthase/LSS Protein, Human, Recombinant (His)	Human	E. coli
	Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens prote...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e...
TMPH-01625	LIPA Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in ...
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...
TMPH-02717	HMGCS1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (H...
TMPH-00491	PNLIPRP1 Protein, Canine, Recombinant (His)	Canine	P. pastoris (Yeast)
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Ca...
TMPH-01626	LIPA Protein, Human, Recombinant (GST)	Human	E. coli
	Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in ...
TMPK-01228	MARCO Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in...
TMPH-01678	MMUT Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropion...
TMPJ-01302	ACAT2 Protein, Human, Recombinant (His)	Human	E. coli
	ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesi...
TMPY-01616	SULT2B1 Protein, Human, Recombinant (His)	Human	E. coli
	Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotr...
TMPH-00218	DHCR7 Protein, Bovine, Recombinant (His)	Bovine	E. coli
	7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in th...
TMPY-00131	Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)	Human	HEK293 Cells
	Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pi...
TMPH-00037	Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)	Aggregatibacter actinomycetemcomitans	P. pastoris (Yeast)
	Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably ...
TMPH-01747	FDXR Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam...
TMPH-00288	Adrenodoxin reductase Protein, Bovine, Recombinant (His)	Bovine	P. pastoris (Yeast)
	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam...
TMPH-00287	Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam...
TMPY-02686	PON3 Protein, Human, Recombinant (S50N, His)	Human	Baculovirus Insect Cells
	PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expressi...
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His)	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in ...
TMPH-00220	Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th...
TMPH-03128	TSPO Protein, Pig, Recombinant (His & Myc & SUMO)	Sus scrofa (Pig)	E. coli
	Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynt...
TMPJ-00481	CELA3A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Chymotrypsin-Like Elastase Family Member 3A (CELA3A) is an enzyme that contains one peptidase S1 domain. ELA3A belongs to the peptidase S1 family of the Elastase subfamily. ELA3A is secreted from the pancreas as a zymoge...
TMPJ-00394	LDLR Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repe...
TMPY-04476	MVK Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol bio...
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CHOD Protein, Streptomyces sp., Recombinant (GST)

TMPH-03605

Species: Streptomyces

Expression System: E. coli

LCAT Protein, Human, Recombinant (His)

TMPY-00055

Species: Human

Expression System: HEK293 Cells

CYP11A1 Protein, Human, Recombinant (His & SUMO)

TMPH-01084

Species: Human

Expression System: E. coli

CYP2C9 Protein, Human, Recombinant (His & Myc)

TMPH-01186

Species: Human

Expression System: E. coli

HMGCR Protein, Human, Recombinant (His)

TMPH-00007

Species: Human

Expression System: E. coli

Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)

TMPY-02956

Species: Human

Expression System: Baculovirus Insect Cells

LCAT Protein, Mouse, Recombinant (His)

TMPK-00835

Species: Mouse

Expression System: HEK293 Cells

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)

TMPH-03593

Species: Streptococcus pneumoniae

Expression System: E. coli

APOA1 Protein, Bovine, Recombinant (His)

TMPH-00225

Species: Bovine

Expression System: P. pastoris (Yeast)

ANXA1 Protein, Cynomolgus, Recombinant (His)

TMPK-01291

Species: Cynomolgus

Expression System: E. coli

YJEFN3 Protein, Human, Recombinant

TMPH-02316

Species: Human

Expression System: E. coli

APOA1 Protein, Bovine, Recombinant (E. coli, His)

TMPH-00224

Species: Bovine

Expression System: E. coli

Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)

TMPH-03592

Species: Streptococcus pneumoniae

Expression System: P. pastoris (Yeast)

GBA Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-01623

Species: Human

Expression System: E. coli

HMGCR Protein, Mouse, Recombinant (His)

TMPH-02476

Species: Mouse

Expression System: E. coli

ANXA1 Protein, Mouse, Recombinant (His)

TMPK-00799

Species: Mouse

Expression System: E. coli

ANXA1 Protein, Human, Recombinant (His)

TMPK-00768

Species: Human

Expression System: E. coli

CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02842

Species: Mouse

Expression System: E. coli

GBA Protein, Human, Recombinant

TMPH-01624

Species: Human

Expression System: E. coli

PMVK Protein, Human, Recombinant (His)

TMPY-04767

Species: Human

Expression System: E. coli

Apolipoprotein A-I/APOA1 Protein, Human, Recombinant

TMPJ-00158

Species: Human

Expression System: E. coli

CD133/PROM1 Protein-VLP, Human, Recombinant (His)

TMPH-00001

Species: Human

Expression System: HEK293 Cells

LIPA Protein, Rat, Recombinant (His)

TMPH-03323

Species: Rat

Expression System: E. coli

PMP2 Protein, Horse, Recombinant (His & SUMO)

TMPH-00831

Species: Horse

Expression System: E. coli

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)

TMPJ-00756

Species: Human

Expression System: HEK293 Cells

PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)

TMPH-00492

Species: Canine

Expression System: E. coli

Lanosterol synthase/LSS Protein, Human, Recombinant (His)

TMPH-01603

Species: Human

Expression System: E. coli

ACAT2 Protein, Rat, Recombinant (His)

TMPY-04813

Species: Rat

Expression System: E. coli

LIPA Protein, Human, Recombinant (His)

TMPH-01625

Species: Human

Expression System: P. pastoris (Yeast)

INSIG2 Protein, Human, Recombinant (His & Myc)

TMPH-01535

Species: Human

Expression System: E. coli

HMGCS1 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02717

Species: Mouse

Expression System: E. coli

PNLIPRP1 Protein, Canine, Recombinant (His)

TMPH-00491

Species: Canine

Expression System: P. pastoris (Yeast)

LIPA Protein, Human, Recombinant (GST)

TMPH-01626

Species: Human

Expression System: E. coli

MARCO Protein, Human, Recombinant (His)

TMPK-01228

Species: Human

Expression System: HEK293 Cells

MMUT Protein, Human, Recombinant (His)

TMPH-01678

Species: Human

Expression System: E. coli

ACAT2 Protein, Human, Recombinant (His)

TMPJ-01302

Species: Human

Expression System: E. coli

SULT2B1 Protein, Human, Recombinant (His)

TMPY-01616

Species: Human

Expression System: E. coli

DHCR7 Protein, Bovine, Recombinant (His)

TMPH-00218

Species: Bovine

Expression System: E. coli

Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)

TMPY-00131

Species: Human

Expression System: HEK293 Cells

Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)

TMPH-00037

Species: Aggregatibacter actinomycetemcomitans

Expression System: P. pastoris (Yeast)

FDXR Protein, Human, Recombinant (His & SUMO)

TMPH-01747

Species: Human

Expression System: E. coli

Adrenodoxin reductase Protein, Bovine, Recombinant (His)

TMPH-00288

Species: Bovine

Expression System: P. pastoris (Yeast)

Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)

TMPH-00287

Species: Bovine

Expression System: E. coli

PON3 Protein, Human, Recombinant (S50N, His)

TMPY-02686

Species: Human

Expression System: Baculovirus Insect Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)

TMPH-00220

Species: Bovine

Expression System: E. coli

TSPO Protein, Pig, Recombinant (His & Myc & SUMO)

TMPH-03128

Species: Sus scrofa (Pig)

Expression System: E. coli

CELA3A Protein, Human, Recombinant (His)

TMPJ-00481

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (Avi & His), Biotinylated

TMPJ-00394

Species: Human

Expression System: HEK293 Cells

MVK Protein, Human, Recombinant (His & GST)

TMPY-04476

Species: Human

Expression System: Baculovirus Insect Cells

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カタログ番号	製品名
L2501	Human Endogenous Metabolite Compound Library Plus	1283 compounds

L5100	Fluorochemical Library	574 compounds
	A unique collection of 574 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);

ライブラリー

Human Endogenous Metabolite Compound Library Plus

L2501

Compounds: 1283

Fluorochemical Library

L5100

Compounds: 574