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T14933 |
Cetaben
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|
Others
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Cetaben is a PPARα-independent peroxisome proliferator and is a non-fibrate hypolipidemic drug. It potent reduces the concentration of cholesterol and triglycerides. |
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T9766 |
GW590735
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|
PPAR
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GW590735 is an effective and selective PPARα agonist with an EC50 of 4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW590735 can be used in dyslipidemia studies. |
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T2499 |
Torcetrapib
|
CP-529414 |
CETP
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|
Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces... |
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T1676 |
Rosuvastatin
|
ZD 4522 |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
|
|
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting... |
|
T1510 |
Rosuvastatin calcium
|
ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
|
|
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
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T19864 |
Xenalipin
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BW 207U |
Others
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Xenalipin (BW 207U) has hypolipidemic. It reduces blood cholesterol and triglycerides in rats. |
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T27691 |
JNJ-DGAT2-A
|
JNJDGAT2A |
Transferase
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|
JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides. |
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T9106 |
E1231
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Sirtuin
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E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. |
|
T16018 |
MB-07811
|
VK-2809 |
Thyroid hormone receptor(THR)
|
|
MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β. |
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T19861 |
Niceritrol
|
Perycit,Cardiolipol,Bufor |
Others
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|
Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions. |
|
T0841 |
Bezafibrate
|
BM15075 |
PPAR
|
|
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS. |
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T28882 |
Sultosilic acid, piperazine salt
|
A-585,Mimedran,piperazine-sultosylate,A585,A 585 |
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Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically signif... |
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T19057 |
Solvent Blue 35
|
Sudan Blue II,Oil Blue 35 |
Others
|
|
Solvent Blue 35 (Sudan Blue II) (Sudan Blue II) is a dye used for coloring hydrocarbon-based and alcoholic solvents. It is used for staining triglycerides in animal tissues. |
|
T15821 |
LY518674
|
LY-674 |
PPAR
|
|
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα). |
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T11386L |
Gemcabene
|
PD-72953 |
Others
|
|
|
|
T15549 |
Icosabutate
|
NST-4016,PRC-4016 |
Others
|
|
Icosabutate (NST-4016) is an orally active derivative of eicosapentaenoic acid that inhibits hepatic inflammation and fibrosis in NASH, improves cardiovascular risk profiles in statin-treated patients with residual hyper... |
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T6267 |
Lomitapide
|
AEGR-733,BMS-201038 |
CETP
|
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Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring... |
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T4681 |
T863
|
DGAT-3,DGAT-1 inhibitor |
Acyltransferase
,
Transferase
|
|
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... |
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T19432 |
Mono-and diglycerides
|
|
Others
|
|
Mono-and diglycerides is formed by triglycerides . |
|
T26345 |
YM-53601
|
YM53601 |
|
|
YM-53601 is a squalene synthase activity inhibitor that acts by lowering cholesterol as well as triglycerides. |
|
T24261 |
KHG26693
|
KHG-26693,KHG 26693 |
|
|
KHG26693 is an anti-inflammatory and antioxidant agent that acts by significantly decreasing blood glucose, triglycerides, cholesterol and increased insulin. |
|
T39303 |
CP-346086
|
|
|
|
CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces pl... |
|
T33660 |
Nicofibrate hydrochloride
|
Nicofibrate HCl,Arterium V,Nicofibrate hydrochloride, |
|
|
Nicofibrate hydrochloride is a biochemical which may cause a significant reduction in plasma cholesterol and triglycerides and bring lipoprotein levels to normal. Nicofibrate HCl may also lead to a significant drop in pl... |
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T11386 |
Gemcabene calcium
|
PD-72953 calcium |
Others
|
|
|
|
T69408 |
GW590735 sodium
|
|
|
|
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased... |
|
T36567 |
DPPP
|
|
|
|
DPPP is a probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule diphenyl-1-pyrenylphosphine oxide (DPPP-O). Plasma levels of lipid hydroperoxides of phosphatidylcholine, phosphatidyle... |
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T74757 |
Didocosahexaenoin
|
|
|
|
Didocosahexaenoin, an omega-3 derivative and diglyceride of DHA synthesized from DHA triglycerides, significantly decreases mitochondrial membrane potential and stimulates ROS (reactive oxygen species) production. It ind... |
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T36765 |
Palmitelaidic Acid methyl ester
|
|
|
|
Palmitoleic acid is a common constituent of the triglycerides of human adipose tissue. Palmitoleic acid-based diets raise low-density lipoprotein cholesterol and diminish high-density lipoprotein cholesterol, even when d... |
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T35800 |
MD001
|
|
|
|
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ... |
|
T37522 |
Teneligliptin
|
|
|
|
Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
Teneli... |
