Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell.
説明 | TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell. |
ターゲット&IC50 | MED12:43 nM(IC50), BAF155:340 nM(IC50) |
別名 | TP 064 |
分子量 | 458.6 |
分子式 | C28H34N4O2 |
CAS No. | 2080306-20-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (272.57 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TP-064 2080306-20-1 Chromatin/Epigenetic Histone Methyltransferase anticancer inhibit TP 064 Inhibitor BAF155 TP064 MED12 CARM1 dimethylation PRMT4 inhibitor