Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VAS2870 is an inhibitor of NADPH oxidase (NOX).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 43,500 | |||
50 mg | 在庫あり | ¥ 79,500 | |||
100 mg | 在庫あり | ¥ 118,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,500 |
説明 | VAS2870 is an inhibitor of NADPH oxidase (NOX). |
In vitro | VAS2870 effectively inhibits the growth and proliferation of FaO rat hepatoma cells and various human hepatocellular carcinoma (HCC) cell lines, while also enhancing TGF-b-mediated apoptosis in these cells. It suppresses the activation of NADPH oxidase and the production of intracellular ROS induced by PDGF-BB, without affecting DNA synthesis. Preincubation with VAS2870 at concentrations of 10 and 20 μM completely prevents PDGF-mediated NADPH oxidase activation and ROS production, although it does not interfere with PDGF-induced cell cycle progression. However, VAS2870 does effectively eliminate PDGF-dependent chemotaxis of VSMC, achieving 100% inhibition at 10 μM. Additionally, VAS2870 dose-dependently reduces autocrine cell number increases in FaO rat hepatoma cells, and at 25 mM, it almost completely blocks ROS production and thymidine incorporation. |
分子量 | 360.39 |
分子式 | C18H12N6OS |
CAS No. | 722456-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.3 mg/mL (231.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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VAS2870 722456-31-7 Metabolism NADPH NADPH Oxidase NOX inhibit VAS 2870 VAS-2870 Inhibitor inhibitor