|
T10498 |
5-HT2A antagonist 1
|
|
5-HT Receptor
|
|
5-HT2A antagonist 1 is a 5-HT2A antagonist. It may be useful in the treatment of gastrointestinal disorders circulatory disorders. |
|
T0280 |
Spiperone
|
Spiroperidol,Spiropitan |
Dopamine Receptor
|
|
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. |
|
T11217 |
Eplivanserin
|
SR-46349 |
5-HT Receptor
|
|
|
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
TQ0084 |
Lumateperone Tosylate
|
ITI-007 |
Dopamine Receptor
,
5-HT Receptor
|
|
lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM). |
|
T6241 |
Quetiapine hemifumarate
|
Quetiapine Fumarate,ICI-204636 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
|
T79155 |
5-HT2A receptor agonist-3
|
|
5-HT Receptor
|
|
5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM. It also demonstrates a remarkable 124-fold selectivity over its structurally an... |
|
T79806 |
5-HT2A&5-HT2C agonist-1
|
|
5-HT Receptor
|
|
5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM. It is applicable in the study of various central nervous system disor... |
|
T8136 |
Perospirone hydrochloride
|
Perospirone HCl,SM-9018 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
|
T61220 |
5-HT6/5-HT2A receptor ligand-2
|
|
|
|
Compound 42, a 5-HT6/5-HT2A receptor ligand-2, serves as a dual antagonist for the 5-HT6 and 5-HT2A receptors with Ki values of 25 nM and 32 nM, respectively. This brain-penetrant compound exhibits pro-cognitive properti... |
|
T61507 |
5-HT2A receptor agonist-2
|
|
|
|
5-HT2A receptor agonist-2 is a potent compound that acts as an agonist on the serotonin 5-HT2 receptor. It specifically stimulates the 5-HT 2A, 5-HT 2B, and 5-HT 2C receptors, with EC 50 values of 1.7 nM, 0.58 nM, and 0.... |
|
T61207 |
5-HT6/5-HT2A receptor ligand-1
|
|
|
|
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in ne... |
|
T21069 |
Lumateperone
|
ITI 722,ITI722,ITI-007,ITI007 |
5-HT Receptor
|
|
Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM). |
|
T14083 |
Abaperidone
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... |
|
T15034 |
Roluperidone
|
CYR-101,MIN-101,MT-210 |
Sigma receptor
,
5-HT Receptor
|
|
Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2). |
|
T10871 |
CP-809101 hydrochloride
|
|
5-HT Receptor
|
|
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
|
T16856 |
SB228357
|
|
5-HT Receptor
|
|
SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively. |
|
T22514 |
4F 4PP oxalate
|
|
5-HT Receptor
|
|
4F 4PP oxalate is a 5-HT2A antagonist. |
|
T17033 |
Temanogrel
|
APD791 |
5-HT Receptor
|
|
Temanogrel (APD791) is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). |
|
T6946 |
Pimavanserin tartrate
|
ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin |
5-HT Receptor
|
|
Pimavanserin tartrate (Nuplazid) is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease. |
|
T22947 |
LY266097 hydrochloride
|
LY 266097 hydrochloride |
5-HT Receptor
|
|
LY266097 hydrochloride (LY 266097 hydrochloride) is an antagonist of 5-HT2 with pKis of 7.7, 9.8, and 7.6 for human 5-HT2A, 5-HT2B, and 5-HT2C and can be used in studies about depression. |
|
T7350 |
Nelotanserin
|
APD125 |
5-HT Receptor
|
|
Nelotanserin (APD125) is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). |
|
T27248 |
Egis-11150
|
|
|
|
Egis-11150 is a potent inhibitor of adrenergic alpha1, alpha2c, 5-HT2a, 5HT7 receptors. |
|
T12480 |
Pipamperone
|
Floropipamide,McN-JR 3345,R 3345 |
Others
,
Dopamine Receptor
,
5-HT Receptor
|
|
Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor. |
|
T22964 |
Glemanserin
|
MDL11939 |
5-HT Receptor
|
|
Glemanserin (MDL11939) is a specific 5-HT2A antagonist with Ki values of 0.54 nM, 2.5 nM and 2.89 nM for rabbit, human and rat 5-HT2A. |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T2076 |
Pimavanserin
|
ACP-103 |
5-HT Receptor
|
|
Pimavanserin (ACP-103)(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic used in the treatment of hallu... |
|
T14782 |
Brilaroxazine
|
RP5063 |
Dopamine Receptor
,
5-HT Receptor
|
|
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... |
|
T16401 |
Org-12962
|
|
5-HT Receptor
|
|
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptor... |
|
T12489 |
Pimethixene
|
Calmixen,Pimetixene |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |
|
T24421 |
LY-2624803
|
DB-7,LY2624803,HY-10275,LY 2624803 |
5-HT Receptor
,
Histamine Receptor
|
|
LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep. |
|
T28680 |
SB-215505
|
|
|
|
SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
|
T23168 |
PNU 22394 hydrochloride
|
|
5-HT Receptor
|
|
PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist |
|
T13110 |
Tedatioxetine hydrobromide
|
Lu AA 24530 hydrobromide |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress... |
|
T10824 |
Cis-Urocanic acid
|
cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid |
5-HT Receptor
|
|
cis-Urocanic acid ((E)-Urocanic acid) is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor. |
|
T28435 |
PNU-96391
|
PNU 96391,OSU6162,PNU96391,OSU 6162,OSU-6162 |
Dopamine Receptor
,
5-HT Receptor
|
|
PNU-96391 (OSU-6162) is an antagonist of dopamine D2 and a partial agonist of 5-HT2A. PNU-96391 can be used in research on the treatment of chronic diseases. |
|
T10100 |
QF0301B
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T15414 |
GR 113808
|
GR-113808 |
5-HT Receptor
|
|
GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors and attenuates morphine-stimulated dopamine release in the rat striatum.CAS 번호12483-87-86-1 |
|
T12899L |
SEP-363856 hydrochloride
|
SEP-856 hydrochloride |
Others
,
5-HT Receptor
|
|
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to trea... |
|
T19680 |
Zotepine
|
|
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... |
|
T23631 |
Adatanserin
|
WY-50324,WY 50324,WAY SEB 324,WY50324 |
5-HT Receptor
|
|
Adatanserin (WY 50324) is a mixed 5-HT1A receptor partial agonist and a 5-HT2A and 5-HT2C receptor antagonist with potential neuroprotective activity for the study of anxiety and depression. |
|
T50039 |
3-(2-aminopropyl)phenol hydrochloride
|
|
Others
|
|
3-(2-aminopropyl)phenol hydrochloride is a phenethylamine analog used as a molecular structural unit. It is a psychoactive drug that is a partial agonist at several serotonin receptors, including 5-HT1A, 5-HT1B, and 5-HT... |
|
T15270 |
Fananserin
|
RP 62203 |
Dopamine Receptor
,
5-HT Receptor
|
|
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopamine D4 receptor (Ki: 2.93 nM for the human dopamine D4 recep... |
|
T22359 |
MDL 100009
|
|
5-HT Receptor
|
|
MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A. |
|
T26543 |
AC-90179 HCl
|
AC 90179,AC-90179 hydrochloride,AC90179,AC-90179 |
5-HT Receptor
|
|
AC-90179 HCl (AC-90179 hydrochloride) is a selective inverse agonist of 5-HT2A receptor. AC-90179 HCl is an atypical antipsychotic pharmaceutical and has been shown to alleviate hallucinogen-induced vasocontriction. |
|
T8357 |
SB-200646
|
|
5-HT Receptor
|
|
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
|
T2306 |
Brexpiprazole
|
OPC-34712 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T0445L |
Promethazine hydrochloride
|
Promethazine HCl,Phenergan |
Adrenergic Receptor
,
Histamine Receptor
|
|
Promethazine hydrochloride (Promethazine HCl) , the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-HT2A, 5-HT2C, D2 and α... |
|
T60221 |
Tabernanthalog
|
TBG |
5-HT Receptor
|
|
Tabernanthalog (TBG) is a 5-HT2A agonist. In rodents,Tabernanthalog has been found to promote structural neuroplasticity, reduce alcohol-seeking and heroin-seeking behavior, and produce antidepressant effects. |
