|
T7208 |
AMD 3465 hexahydrobromide
|
GENZ-644494 (hexahydrobromide) |
HIV Protease
,
CXCR
|
|
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity. |
|
T22565 |
AMD-070 hydrochloride
|
|
CXCR
|
|
AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV. |
|
TQ0174 |
Mavorixafor
|
AMD-070 |
CXCR
|
|
|
|
T29957 |
AMD-7049
|
AMD 7049 |
|
|
AMD-7049 is a biochemical. |
|
T1776 |
Plerixafor
|
JM3100,AMD 3100,AMD-3329 |
Virus Protease
,
HIV Protease
,
CXCR
|
|
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4. |
|
T29958 |
AMD-9370
|
|
|
|
AMD-9370 is a biochemical. |
|
T14208 |
AMD 3465
|
GENZ-644494 |
HIV Protease
|
|
|
|
T1776L |
Plerixafor octahydrochloride
|
JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl |
Virus Protease
,
HIV Protease
,
CXCR
|
|
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a... |
|
T70260 |
AMD-3329 hydrobromide
|
|
|
|
AMD-3329 hydrobromide is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. |
|
T69583 |
AMD-3451 trihydrochloride
|
|
|
|
AMD-3451 trihydrochloride is a CCR5/CXCR4 dual antagonist that may be useful in the treatment of HIV. |
|
T69582 |
AMD-3451 free base
|
|
|
|
AMD-3451 free base is a dual CCR5/CXCR4 antagonist which may be useful in the treatment of a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2. AMD3451 is the first low-mo... |
|
T10296 |
Mavorixafor trihydrochloride
|
AMD-070 trihydrochloride |
HIV Protease
|
|
|
|
T70259 |
AMD-3329 free base
|
|
|
|
AMD-3329 free base is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. |
|
T21323 |
Picoplatin
|
NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473 |
|
|
Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition ... |
|
T8574 |
SPHINX
|
|
Others
|
|
SPHINX is a new generation inhibitor of SPRK1 |
|
T9928 |
Ranibizumab
|
|
VEGFR
|
|
Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n... |
|
T23716 |
AMDE-1
|
AMDE 1 |
Autophagy
|
|
AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation. |
|
T29959 |
Amdinocillin methylacetate
|
Mecillinam acetylmethyl ester |
|
|
Amdinocillin methylacetate is a Synthetic penicillin. |
|
T26615 |
Amdoxovir
|
AMDX,DAPD |
|
|
Amdoxovir is a reverse transcriptase inhibitor. |
|
T39327 |
Amdizalisib
|
Amdizalisib,HMPL-689 |
|
|
Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer. |
|
T69725 |
Amdakefalin
|
|
|
|
Amdakefalin is a μ and δ opioid receptors agonist that acts as an analgesic. |
|
T13157 |
TG 100801
|
TG100801,TG 100572 |
VEGFR
,
Src
|
|
TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD). |
|
T3306 |
PF-04418948
|
PF 04418948,PF04418948 |
Prostaglandin Receptor
|
|
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... |
|
T7493 |
AG-13958
|
AG-013958 |
VEGFR
|
|
AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration. |
|
T69452 |
AG-13958 monohydrochloride
|
|
|
|
AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic bl... |
|
TP1390 |
CEP dipeptide 1
|
|
|
|
CEP dipeptide 1, a potent angiogenic compound, exhibits robust activity in promoting angiogenesis. This compound is specifically implicated in the pathogenesis of age-related macular degeneration (AMD). |
|
T39706 |
Pegaptanib sodium
|
|
|
|
Pegaptanib sodium, an RNA aptamer specifically targeting vascular endothelial growth factor (VEGF)-165, holds great promise for investigating neovascular age-related macular degeneration (AMD). |
|
T77016 |
Galegenimab
|
|
|
|
Galegenimab (FHTR 2163; RG 6147; RO 7171009), an antibody fragment targeting High-temperature requirement A1 (HTRA1), is utilized in the research of age-related macular degeneration (AMD) [1]. |
|
T79010 |
Lp-PLA2-IN-12
|
|
Phospholipase
|
|
Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions... |
|
T76987 |
Tarcocimab
|
|
|
|
Tarcocimab (OG1953), a humanized IgG1-type anti-VEGFA monoclonal antibody, is utilized in research targeting conditions such as retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD). |
|
T74551 |
Avacincaptad pegol sodium
|
|
|
|
Avacincaptad pegol (ARC1905), an anti-C5 RNA aptamer, prevents the cleavage of complement factor 5 (C5) into fragments C5a and C5b. It is currently under investigation for the treatment of age-related macular degeneratio... |
|
T28008 |
MDVN1003
|
MDVN 1003,MDVN-1003 |
|
|
MDVN1003 is a potent inhibitor of BTK amd PI3Kδ, two proteins regulated by the B cell receptor (BCR) that drive the growth of many NHLs. MDVN1003 induces cell death in a B cell lymphoma cell line but not in an irrelevant... |
|
T76814 |
Lampalizumab
|
|
|
|
Lampalizumab (RG 7417), a humanized monoclonal antibody, selectively inhibits complement Factor D in the alternative complement pathway by binding to an exosite and sterically hindering Factor B's access to the active si... |
|
TP1464 |
Risuteganib hydrochloride
|
|
|
|
Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order ... |
|
T74552 |
Non-PEGylated/naked ARC1905
|
|
|
|
ARC1905, a non-PEGylated/naked anti-C5 RNA aptamer, functions by inhibiting the cleavage of complement factor 5 (C5) into its components, C5a and C5b, without PEG conjugation. This compound is currently being researched ... |
|
T74867 |
UBX1325
|
|
|
|
UBX1325, a Bcl-xL inhibitor, enhances apoptosis in senescent cells, serving as an effective anti-aging agent. It holds potential for age-related eye disease research, including diabetic macular oedema (DME), age-related ... |
|
T75156L |
Bevasiranib sodium
|
|
|
|
Bevasiranib sodium, an siRNA compound, targets and silences the genes responsible for producing vascular endothelial growth factor (VEGF). The suppression of VEGF, a critical factor in the development of choroidal neo-va... |
|
T75156 |
Bevasiranib
|
|
|
|
Bevasiranib, a siRNA, is specifically engineered to suppress the expression of genes responsible for the production of vascular endothelial growth factor (VEGF), a critical factor in the development of choroidal neo-vasc... |
|
T79074 |
Lp-PLA2-IN-14
|
|
Phospholipase
|
|
Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4. This compound is applicable in research pertaining to neurodegenerative disorders, including Alzheime... |
|
T63192 |
Lp-PLA2-IN-10
|
|
|
|
Lp-PLA2-IN-10 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), formerly known as platelet-activating factor acetylhydrolase (PAF-AH). This enzyme plays a role in the hydrolysis of lipoprotein l... |
|
T33267 |
Me6TREN 4HCl
|
Me6TREN Tetrahydrochloride,Me6-TREN Tetrahydrochloride,Me6 4HCl,Me 6 4HCl,Me-6 4HCl |
|
|
Me6TREN 4HCl is a potent and efficacious mobilizing agent of hematopoietic stem and progenitor cells (HSPCs) that can act by activating MMP-9 expression and disrupting the SDF-1α/CXCR4 axis, exhibiting more significant m... |
