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T15641 |
K777
|
APC-3316 |
P450
,
Cysteine Protease
,
CCR
|
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K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ... |
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T69182 |
APC-3316 hydrochloride
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APC-3316 hydrochloride is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist. |
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T39029 |
APC-6860
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APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA ve... |
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T40081 |
APC 366 TFA
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APC 366 (TFA) is a potent irreversible inhibitor of mast cell tryptase. It is particularly useful in studies related to allergic diseases. |
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T38466 |
4-APC hydrobromide
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4-APC hydrobromide is a potent and specific aldehyde derivatization agent. It contains an aniline moiety that enables rapid and selective reaction with aliphatic aldehydes, as well as a quaternary ammonium group that enh... |
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T22189 |
APC 366
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APC 366 is a selective inhibitor of mast cell tryptase with Ki of 7.1 μM. APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep... |
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T30094 |
APC-6336
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UNII-4124YUO44Z,CRA-6336,4124YUO44Z |
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APC-6336 is a bio-active chemical. |
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T69453 |
APC-0576
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APC-0576 is an (S,S)-isomer which inhibits NF-kappaB-dependent gene activation. APC-0576 may prevent pro-inflammatory cytokine-induced chemokine production in human endothelial cells. |
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T12766 |
RPR121056
|
APC |
AChR
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RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I. |
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T69183 |
APC-3316 tosylate
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APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist. |
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T70193 |
APC-366 HCl
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APC-366 is a selective inhibitor of the mast cell tryptase that inhibits tryptase-induced histamine release from human tonsil and lung cells. |
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T8561 |
Apcin
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APC
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Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substr... |
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T70192 |
NC-2100
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NC-2100 is an aperoxisome proliferator-activated receptor-gamma (PPARgamma) activator. |
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T22884 |
JW 67
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Wnt/beta-catenin
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JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. |
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T12575 |
Unesbulin
|
PTC596 |
Apoptosis
,
BMI-1
|
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Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1). |
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T1731 |
TAME hydrochloride
|
Tos-Arg-OMe HCl,TOS-ARG-OME hydrochloride |
Amino Acids and Derivatives
,
APC
|
|
TAME hydrochloride (Tos-Arg-OMe HCl) is a kind od amino acid derivatives. |
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T6693 |
TAME
|
Tosylarginine methyl ester,N-4-Tosyl-L-arginine methyl ester |
APC
|
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Tosyl-L-Arginine Methyl Ester (TAME (N-4-Tosyl-L-arginine methyl ester)) is an APC inhibitor. |
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T64339 |
Apcin A HCL
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APC
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Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to... |
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T74235 |
DHAPC
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DHAPC is a phospholipid that is very sensitive to oxidation [1] . |
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T10345 |
Apcin-A
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Others
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Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V. |
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T82888 |
Bibapcitide
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Bibapcitide, a 26-amino-acid peptide, acts as a thrombosis inhibitor [1]. |
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T37035 |
HAPC-Chol
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HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also bee... |
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T37586 |
DMHAPC-Chol
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DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B... |
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T37027 |
MHAPC-Chol
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MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also b... |
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T71654 |
APcK110
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APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3... |
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T24855 |
TASIN-1 Hydrochloride
|
TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl |
APC
|
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TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt... |
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T22632 |
TASIN-1
|
1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine |
APC
|
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TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC). |
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TP1628L |
Activated Protein C (390-404), human acetate
|
Activated Protein C (390-404), human acetate(146340-20-7 Free base) |
APC
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Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity. |
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T22646 |
CFM 4
|
CFM-4,CFM4 |
Apoptosis
,
APC
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CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.CFM 4 inhibits the g... |
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T2052 |
KY02111
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|
Wnt/beta-catenin
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KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC. |
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T8509 |
Danicopan
|
ACH-4471 |
Complement System
|
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Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ... |
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T81876 |
MAIT-203
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|
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MAIT-203, a cyclopentyalanin-derived peptidomimetic, effectively disrupts the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), without affecting APC-Sam68 or APC-striatin interactions. It binds to... |
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T28455 |
ProTAME
|
pro-Tosyl-L-Arginine Methyl Ester |
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ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell line... |
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TP1580 |
Activated Protein C (390-404), human TFA
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|
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The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular subs... |
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TP1196 |
D-Lys(Z)-Pro-Arg-pNA
|
Chromozym Pca |
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D-Lys(Z)-Pro-Arg-pNA is a luminescent substrate of activated protein C (APC). |
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TP1995 |
MAIT 203
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|
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Inhibits interaction of APC and Asef (RhoGEF4). Inhibits colorectal cancer cell migration and invasion in vitro. |
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T23875 |
CFM-1
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CFM 1,CFM1 |
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CFM-1 is an antagonist of the anaphase-promoting complex (APC)-2. It also is a cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonist. |
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TP1628 |
Activated Protein C (390-404), human
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Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1]. |
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T28247 |
ONO-1714 HCl
|
ONO-1714,ONO1714,ONO-1714 hydrochloride,ONO 1714 |
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ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also ... |
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T82526 |
Drotrecogin alfa (activated)
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Drotrecogin alfa (activated) (DrotAA), a recombinant human activated protein C (APC), mitigates smoke-induced elevations in pulmonary microvascular permeability and proinflammatory cytokine IL-1β levels in rats. It also ... |
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T27760 |
KYA1797
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KYA1797 is an inhibitor of the Wnt/ß-catenin pathway. KYA1797 binds directly to the regulators of G-protein signaling domain of axin, initiats ß-catenin and Ras degradation through enhancement of the ß-catenin destructio... |
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T38052 |
CRA-2059 TFA
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|
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CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Tryptase is a trypsin-like serine protease found as a major protein component in human ma... |
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T78332 |
Eftilagimod alfa
|
IMP321,LAG-3Ig |
|
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Eftilagimod alfa (IMP321), a recombinant LAG-3Ig fusion protein, binds to MHC class II and mediates the activation of antigen-presenting cells (APCs), which in turn activates CD8 T-cells. It is utilized in the research o... |
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T38051 |
CRA-2059 hydrochloride
|
|
|
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CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Tryptase is a trypsin-like serine protease found as a major protein compone... |
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T82517 |
DYSP-C34
|
|
|
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DYSP-C34, a potent ultrasound (US)-triggered multifunctional molecular machine, exhibits a favorable lipophilic/hydrophilic balance, enhanced US-induced reactive oxygen species (ROS) production, and improved cellular per... |
