|
T22884 |
JW 67
|
|
Wnt/beta-catenin
|
|
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. |
|
T1580 |
Desvenlafaxine
|
WY 45233 Succinate,O-Desmethylvenlafaxine |
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive age... |
|
T5380 |
Ansofaxine hydrochloride
|
LPM570065,LY03005 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Ansofaxine hydrochloride (LY03005) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively). |
|
T2064 |
Semaxinib
|
SU5416 |
VEGFR
|
|
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the... |
|
T2496 |
(Z)-Semaxinib
|
SU5416 |
VEGFR
|
|
(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w... |
|
T0472 |
Venlafaxine hydrochloride
|
Venlafaxine HCl,Wy 45030 hydrochloride |
5-HT Receptor
,
Serotonin Transporter
|
|
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. |
|
T22453 |
Venlafaxine
|
Wy 45030 |
Serotonin Transporter
|
|
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia. |
|
T10415 |
Autotaxin-IN-3
|
|
PDE
|
|
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma. |
|
TP2068L |
Cyclotraxin B acetate(1203586-72-4 free base)
|
|
Trk receptor
|
|
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold... |
|
T6188 |
Desvenlafaxine succinate hydrate
|
O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,Desvenlafaxine Succinate |
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Desvenlafaxine succinate hydrate (WY 45233 Succinate) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI). |
|
T73977 |
(S)-Dehydro Venlafaxine
|
|
|
|
(S)-Dehydro Venlafaxine is an inactive S-enantiomer of Dehydro Venlafaxine. Dehydro Venlafaxine is an impurity of Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a potent serotonin (5-HT)... |
|
T41060 |
Ansofaxine
|
Ansofaxine,LPM570065freebase,Toludesvenlafaxine,LY03005freebase |
|
|
Ansofaxine, an SNRI compound, is commonly utilized in depression research as a serotonin-norepinephrine reuptake inhibitor. |
|
T10418 |
Autotaxin modulator 1
|
|
PDE
|
|
Autotaxin modulator 1 is a new modulator of Autotaxin. |
|
TP2404 |
Relaxin C-peptide
|
Relaxin (79-92) |
|
|
Relaxin C-peptide, as a synthetic 14-amino acid peptide found in human decidua & placenta, can represent a partial sequence of human relaxin connecting peptide. |
|
T75832 |
Cyclotraxin B TFA
|
|
|
|
Cyclotraxin B TFA, a cyclic peptide, serves as a highly potent and selective non-competitive inhibitor of TrkB, effectively impeding BDNF-triggered TrkB activity without altering BDNF binding affinity, evidenced by an IC... |
|
T27976 |
Manifaxine
|
BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659 |
|
|
Manifaxine, a norepinephrine-dopamine reuptake inhibitor, is used potentially for the treatment of attention deficit. |
|
T10416 |
Autotaxin-IN-4
|
|
PDE
|
|
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. |
|
TP2068 |
Cyclotraxin B
|
|
|
|
Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also sho... |
|
TMIH-0001 |
(+/-)-Venlafaxine-d6 HCl
|
|
|
|
(+/-)-Venlafaxine-d6 HCl is a deuterated compound of (+/-)-Venlafaxine HCl. (+/-)-Venlafaxine HCl has a CAS number of 99300-78-4. Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions... |
|
TMIH-0004 |
(R)-Desmethyl Venlafaxine-d6
|
|
|
|
(R)-Desmethyl Venlafaxine-d6 is a deuterated compound of (R)-Desmethyl Venlafaxine. |
|
T38134 |
(S)-O-Desmethyl Venlafaxine N-Oxide
|
|
|
|
(S)-O-Desmethyl Venlafaxine N-Oxide, an N-oxide derivative of (S)-O-Desmethyl Venlafaxine, constitutes an active metabolite of the serotonin-norepinephrine reuptake inhibitor (SNRI) class antidepressant, Venlafaxine[1][2... |
|
T60508 |
(S)-Venlafaxine
|
|
|
|
(S)-Venlafaxine is the (S)-configuration of Venlafaxine which is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor with antidepressant activity [1]. |
|
T30237 |
Axinylsterol
|
|
|
|
Axinylsterol is a biochemical. |
|
T81300 |
Relaxin H3 (human)
|
|
|
|
Relaxin H3 (human) is a relaxin peptide that exhibits antifibrotic effects through activation of RXFP1 [1]. |
|
T80447 |
Pardaxin P5
|
|
|
|
Pardaxin P5, an antimicrobial peptide, inhibits Escherichia coli at a minimum inhibitory concentration (MIC) of 13 μM [1]. |
|
T10417 |
Autotaxin-IN-5
|
|
PDE
|
|
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. |
|
T14352 |
Autotaxin-IN-1
|
|
PDE
|
|
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1]. |
|
T72837 |
Autotaxin-IN-6
|
|
|
|
Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and is capable of attenuating cell migration with potential applications in anticancer research [1]. |
|
T2651 |
IWR-1
|
IWR-1-endo,endo-IWR 1 |
Wnt/beta-catenin
|
|
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM). |
|
T11571 |
HLY78
|
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin
|
|
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. |
|
T6989 |
SKL2001
|
|
Wnt/beta-catenin
|
|
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. |
|
T35550 |
FRATide
|
|
|
|
FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein. |
|
T27760 |
KYA1797
|
|
|
|
KYA1797 is an inhibitor of the Wnt/ß-catenin pathway. KYA1797 binds directly to the regulators of G-protein signaling domain of axin, initiats ß-catenin and Ras degradation through enhancement of the ß-catenin destructio... |
|
T69880 |
YW2065
|
|
|
|
YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-... |
