|
T24610 |
Pegamotecan
|
Prothecan,PEG-camptothecin,PEG-beta-CPT |
Topoisomerase
|
|
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers. |
|
T77701 |
FL118
|
FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin |
Survivin
|
|
FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s... |
|
T40049 |
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
|
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin |
|
|
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a mono... |
|
T27113 |
Camptothecin-20(S)-O-propionate
|
CZ 48,CZ48,CZ-48 |
|
|
CZ-48 is a DNA topoisomerase inhibitor. |
|
T83468 |
10NH2-11F-Camptothecin
|
|
|
|
10NH2-11F-Camptothecin, an antibody-drug conjugate (ADC), exhibits antitumor activity and is utilized in cancer research [1]. |
|
T83244 |
7Ethanol-10NH2-11F-Camptothecin
|
|
|
|
7Ethanol-10NH2-11F-Camptothecin, an antibody drug conjugate (ADC), demonstrates inhibitory effects on tumor growth and is utilized in cancer research [1]. |
|
T81833 |
MC-GGFG-AM-(10NH2-11F-Camptothecin)
|
|
|
|
MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody-drug conjugate (ADC) that exhibits antitumor activity by targeting TROp-2 with the sacituzumab antibody through a hydrolysable, pH-sensitive linker. It is utilized in ca... |
|
T81834 |
MC-GGFG-(7ethanol-10NH2-11F-Camptothecin)
|
|
|
|
MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) is a protease-cleavable drug-linker conjugate utilized in antibody-drug conjugates (ADCs), featuring an MC-GGFG linker that allows for enzymatic cleavage [1]. |
|
T75134 |
MC-GGFG-AM-(10Me-11F-Camptothecin)
|
|
|
|
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD... |
|
T79883 |
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
|
|
Topoisomerase
|
|
9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential applications in anticancer research [1]. |
|
T77820 |
7-Aminomethyl-10-methyl-11-fluoro camptothecin
|
|
|
|
7-Aminomethyl-10-methyl-11-fluoro camptothecin, serving as a cytotoxic component of the antibody-drug conjugate (ADC) MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, is employed in the synthesis of ca... |
|
T71135 |
Calphostin I
|
|
|
|
Calphostin I is isolated from the fungus Cladosporium cladosporioides and is an inhibitor of protein kinase C (PKC). |
|
T7551 |
Belotecan hydrochloride
|
CKD-602 |
Topoisomerase
|
|
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity |
|
T15168 |
DRF-1042
|
|
Topoisomerase
|
|
DRF-1042 is an orally active camptothecin analog with anticancer and insecticidal activity that inhibits DNA topoisomerase I. DRF-1042 has been used in the study of solid tumors, such as prostate and colon cancers. |
|
T7187 |
Genz-644282
|
Genz644282 |
Topoisomerase
|
|
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. |
|
T21319 |
Gimatecan
|
LBQ707,STI481 |
Topoisomerase
|
|
Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
|
T60163 |
Lurtotecan
|
GI147211,OSI-211 |
Topoisomerase
|
|
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects. |
|
T71137 |
Simmitecan hydrochloride
|
|
Topoisomerase
|
|
Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors. |
|
T21319L |
Gimatecan HCl
|
ST1481 HCL,Gimatecan HCl(292618-32-7 Free base) |
Topoisomerase
|
|
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
|
T30522 |
BMS-422461
|
BMS422461,BMS 422461 |
|
|
BMS-422461 is a prodrug of the novel fluoro-substituted camptothecin analog, BMS-286309. |
|
T70380 |
ZBH-1205
|
|
|
|
ZBH-1205 is a novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than cpt-11 and sn38 at inhibiting topoismerase-1 |
|
T40879 |
7-MAD-MDCPT
|
|
|
|
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs). |
|
T73534 |
T01-1
|
|
|
|
T01-1, a derivative of camptothecin, is an anticancer agent demonstrating significant anti-proliferative activity. |
|
T39941 |
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT
|
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT |
|
|
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a drug-linker conjugate for antibody-drug conjugate (ADC). |
|
T39681 |
Elomotecan hydrochloride
|
BN 80927 |
|
|
Elomotecan hydrochloride (BN 80927), a camptothecin analog from the homocamptothecin family (hCPT), is a highly potent inhibitor of both topoisomerases I and II. It demonstrates superior efficacy in reducing the prolifer... |
|
T14340 |
Atiratecan
|
TP300 |
Others
|
|
Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. A... |
|
T77816 |
Deruxtecan analog 2
|
|
|
|
Deruxtecan Analog 2 (example 9 P3), a Deruxtecan derivative, serves as an agent-linker conjugate integrating Camptothecin (CPT), a Topo I inhibitor active against colorectal, breast, lung, and ovarian cancers, with a dis... |
|
T62225 |
Topoisomerase I inhibitor 8
|
|
|
|
Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells. |
|
T74494 |
Antitumor agent-63
|
|
|
|
Antitumor Agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, serves as a non-toxic antitumor agent showing high stability and very weak direct inhibition of topoisomerase I (Topo I) [1], demonst... |
|
T69862 |
Afeletecan HCl
|
|
|
|
Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex a... |
|
T72756 |
Gly-7-MAD-MDCPT
|
|
|
|
Gly-7-MAD-MDCPT is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin compound, it shows cytotoxicity to various cancer cells with IC 50 values of 10-1000 nM [1] . |
|
T14454 |
Azido-PEG5-acid
|
|
Others
|
|
Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as the conjugate CPT-APO (CPT: Camptothecin. |
|
T23654 |
Afeletecan free base
|
BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan |
|
|
Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps ... |
|
T14945 |
CH-0793076
|
TP3076 |
Topoisomerase
|
|
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisome... |
|
T62435 |
Belotecan
|
|
|
|
Belotecan (CKD-602 free base) is an inhibitor of DNA topoisomerase I. Belotecan blocks the cell cycle and induces apoptosis and is an antitumour derivative of camptothecin that can be used in cancer research. |
|
T28648 |
S39625
|
S-39625,S 39625 |
|
|
S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and pers... |
|
T73672 |
CH-0793076 TFA
|
|
|
|
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC 50 of 2.3 μM. CH-0793076 TFA is efficacious against cells ex... |
|
T68062 |
Elomotecan
|
BN 80927 free base |
|
|
Elomotecan (BN 80927 free base), a camptothecin analog from the homocamptothecin family (hCPT), serves as a potent inhibitor of topoisomerases I and II. It effectively reduces the proliferation of various tumor cells mor... |
|
T73422 |
CPT-Se4
|
|
Topoisomerase
|
|
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations... |
|
T73421 |
CPT-Se3
|
|
Topoisomerase
|
|
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols w... |
|
T83854 |
BRC4wt TFA
|
|
|
|
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide... |
