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Search Results for " DCA "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T17731L	CL2A-SN-38 DCA 1279680-68-0(free base)		Others
	CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito...		Others
T13538	AlbA-DCA		ROS
	AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in the tumor micr...		ROS
T27551	Honokiol DCA	Honokiol Bis-Dichloroacetate
	Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo...
T60400	LDCA		Apoptosis , Dehydrogenase
	LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. ...		Apoptosis , Dehydrogenase
T23969	DCAI		Others
	DCAI is an inhibitor of nucleotide exchange and nucleotide release acting by binding to the pocket adjacent to the Ras-SOS interface.		Others
T81788	Mito-SilylDCA
	Mito-SilylDCA, a mitochondrial-targeted pyruvate dehydrogenase kinase (PDK1) inhibitor, possesses a thiamine pyrophosphate (TPP) moiety for PDK1 targeting within the mitochondrial network, several dichloroacetate (DCA) g...
T27127	DCAT Maleate	DCAT
	DCAT Maleate is an inhibitor of N-methyl transferases (NMT). DCAT Maleate methylate non-methylated pre-neurotoxins to prevent the formation of Parkinson's syndrome neurotoxins.
T72006	DCAI Hydrochloride
	DCAI hydrochloride is an inhibitor of nucleotide exchange and nucleotide release, by binding to the pocket adjacent to the Ras-SOS interface.
T82603	DCAF1 binder 2
	DCAF1 Binder 2, an E3 ligase ligand, is implicated in BRD9, kinase, and selective Bruton's tyrosine kinase (BTK) degradation.
T77965	DCAF1 binder 1
	DCAF1 Binder 1 selectively targets the CRL4 DCAF1 E3 ligase complex as a ligand, playing a role in targeted protein degradation (TPD) [1].
T14778	BRD6989		IL Receptor , CDK , Interleukin
	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex...		IL Receptor , CDK , Interleukin
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ...
T27537	Hexafluoro
	Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo.

Compounds

CL2A-SN-38 DCA 1279680-68-0(free base)

Synonym: Honokiol Bis-Dichloroacetate

Target: Apoptosis, Dehydrogenase

DCAI

Target: IL Receptor, CDK, Interleukin

カタログ番号	製品名	別名	ターゲット
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
TN6015	N-Methyllindcarpine	2,11-Dihydroxy-1,10-dimethoxyaporphine
	N-Methyllindcarpine is a natural product of Lindera, Lauraceae. The catalog number is TN6015 and the CAS number is 14028-97-8. N-Methyllindcarpine can be used as a reference standard.
T36585	Isodeoxycholic Acid	isoDCA	Chloride channel , Antibacterial
	Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less...		Chloride channel , Antibacterial

天然物製品

Sodium dichloroacetate

T3604

Synonym: Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

N-Methyllindcarpine

TN6015

Synonym: 2,11-Dihydroxy-1,10-dimethoxyaporphine

Target: Chloride channel, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01205	DCAF7 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the f...
TMPK-00505	BDCA-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	BDCA-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 20.55 kDa and the accession number is A0A2K5UWP4.
TMPK-00964	MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPK-01120	BDCA-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BDCA-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 20.93 kDa and the accession number is Q8WTT0-1.
TMPK-01121	BDCA-2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	BDCA-2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 46.39 kDa and the accession number is Q8WTT0-1.
TMPJ-01152	MAdCAM-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MAdCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-65 KDa and the accession number is Q4PKD0.
TMPK-00504	BDCA-2 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	BDCA-2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 44.99 kDa and the accession number is A0A2K5UWP4.
TMPJ-01150	MAdCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	MAdCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is Q4PKD0.
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant...
TMPK-01031	MAdCAM-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPK-00506	BDCA-2 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293 Cells
	BDCA-2 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 46.00 kDa and the accession number is A0A2K5UWP4.
TMPK-01119	BDCA-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	BDCA-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 47.1 kDa and the accession number is Q8WTT0-1.
TMPK-00966	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His)	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPJ-01151	MAdCAM-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	MAdCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 75-100 KDa and the accession number is Q4PKD0.
TMPK-00965	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPH-01204	DCAF4 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
TMPK-01118	BDCA-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	BDCA-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 22.7 kDa and the accession number is Q8WTT0-1.
TMPH-00110	UGT72B1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Bifunctional O-glycosyltransferase and N-glycosyltransferase that can detoxify xenobiotics. Possesses high activity to metabolize the persistent pollutants 2,4,5-trichlorophenol (TCP) and 3,4-dichloroaniline (DCA). Also ...
TMPJ-01372	Cornulin Protein, Human, Recombinant (His)	Human	E. coli
	Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter...