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T11211 |
EP4 receptor antagonist 1
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Prostaglandin Receptor
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EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and... |
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T77699 |
EP4-IN-1
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Prostaglandin Receptor
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EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor diseases. |
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T38595 |
EP4 receptor antagonist 3
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EP4 receptor antagonist 3 |
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EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rhe... |
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T83779 |
EP4 Antagonist 14
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Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... |
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T60840 |
EP4 receptor antagonist 4
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EP4 receptor antagonist 4 is an agonist of EP4 receptor (human pEC 50 = 6.3) [1]. |
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T63100 |
EP4 receptor antagonist 2
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EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects. |
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T9622 |
MF-766
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Prostaglandin Receptor
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MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It... |
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T5841 |
Travoprost
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Flu-Ipr,Fluprostenol isopropyl ester,AL6221 |
Prostaglandin Receptor
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Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist. |
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T37701 |
Pep4c
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pep4c |
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pep4c can be used for related research in the field of life sciences. Its product number is T37701 and CAS number is 243843-43-8. |
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TQ0292 |
Grapiprant
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AAT-007,RQ-00000007,CJ-023423 |
Prostaglandin Receptor
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Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). |
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TQ0025 |
E7046
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Prostaglandin Receptor
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E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. |
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T62525 |
TP-16
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Prostaglandin Receptor
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TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo. |
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TQ0290 |
ONO-AE3-208
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AE 3-208 |
Prostaglandin Receptor
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ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. |
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T14975 |
CJ-42794
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CJ-042794 |
Others
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CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... |
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T15681 |
L-161982
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Prostaglandin Receptor
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L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. |
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T1978 |
GW627368
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GW 627368X |
Prostaglandin Receptor
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GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor. |
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T8993L |
BGC-20-1531 hydrochloride(1186532-61-5 free base)
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BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride |
Prostaglandin Receptor
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BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine. |
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T5482 |
TG4-155
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Prostaglandin Receptor
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TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels |
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T63349 |
Treprostinil diethanolamine
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UT-15C |
Prostaglandin Receptor
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Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FPKi, respectively. Treprostinil diethanolamine i... |
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T3306 |
PF-04418948
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PF 04418948,PF04418948 |
Prostaglandin Receptor
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PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... |
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T1562 |
Rebamipide
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Proamipide,OPC12759 |
Free radical scavengers
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COX
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Prostaglandin Receptor
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Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... |
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T78710 |
AMX12006
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Prostaglandin Receptor
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AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1]. |
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T15690 |
L-902688
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Prostaglandin Receptor
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L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors. |
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T26497 |
AAT-008
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AAT008 |
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AAT-008 is a PGE2 receptor EP4 antagonist. |
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T12061 |
MK-2894
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Others
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MK-2894 is a highly potent and selective antagonist of second generation EP4 . |
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T12060 |
MK-2894 sodium salt
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Others
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MK-2894 sodium salt is a highly potent and selective antagonist of second generation EP4. |
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T14500 |
BAY-1316957
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Prostaglandin Receptor
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BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1]. |
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T15689 |
L-798106
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CM9,GW671021 |
Prostaglandin Receptor
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L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively). |
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T16069 |
MF498
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Others
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MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM). |
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T27279 |
ER819762
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ER-819762,ER 819762 |
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ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion. |
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T71269 |
ASP7657
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ASP7657 is a novel, potent, and selective prostaglandin EP4 receptor antagonist. |
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T15642 |
KAG-308
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Prostaglandin Receptor
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KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and pro... |
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T69590 |
ONO-AE1-329
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ONO-AE1-329 is a novel agonist of the prostaglandin PGE2 receptor EP4. |
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T31054 |
CP-432
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CP432,CP734432,CP 734432,CP-734432 |
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CP-432 (CP-734432) is an EP4 prostaglandin agonist for the treatment of glaucoma and ocular hypertension. |
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T23448 |
TCS 2510
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Others
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EP4 agonist |
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T37441 |
KMN-80
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The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which pla... |
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T10046 |
16,16-Dimethyl prostaglandin E2
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16,16-dimethyl PGE2 |
Prostaglandin Receptor
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16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway. |
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T8993 |
BGC201531
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AP-1531,GTPL3380,BGC-20-1531 |
Prostaglandin Receptor
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BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine. |
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T79432 |
NXT-10796
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Prostaglandin Receptor
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NXT-10796 is an orally active, intestinally restricted agonist of the EP4 receptor [1]. |
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T11499 |
GSK726701A
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Others
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T36080 |
Rivenprost
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ONO-4819 |
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Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively).... |
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T70718 |
CR-6086
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CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct fr... |
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T63316 |
BGC-20-1531 free base
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BGC-20-1531 (PGN 1531) free base is a selective and potent prostaglandin EP4 receptor antagonist (pKB: 7.6) that exhibits potential for migraine research. |
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T14139 |
Aganepag
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AGN 210937 |
Prostaglandin Receptor
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Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, s... |
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T26925 |
Butaprost
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Butaprostum,TR-4979,(R)-Butaprost |
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Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butap... |
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T78582 |
15-keto-Prostaglandin E2
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15-keto-PGE2 |
Prostaglandin Receptor
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15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression. Additionally, it binds and stabilizes the EP2 and EP4 recep... |
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T29907 |
Alprostadil sodium
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PGE1 sodium salt,Prostaglandin E1 sodium |
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Alprostadil sodium is a prostaglandin receptor ligand with Ki values of 36, 10, 1.1, 2.1, and 33 nM for EP1, EP2, EP3, EP4, and IP, respectively, in mice.It induces vasodilatation and inhibits platelet aggregation, and i... |
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T71510 |
MF-592
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MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (... |
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T37996 |
17-phenyl trinor Prostaglandin E2 ethyl amide
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17-phenyl trinor Prostaglandin E2 ethyl amide |
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17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rat... |
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T40738 |
CAY10580
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CAY10580 |
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CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM). |
