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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6967 | RHPS4 | RHPS 4 methosulfate,NSC714187 | Apoptosis , Telomerase |
RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar. | |||
T4327 | Prexasertib dihydrochloride | LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 | Apoptosis , Chk , S6 Kinase |
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. | |||
T4310 | Prexasertib | LY2606368 | Apoptosis , Chk |
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. | |||
T1767 | BMH-21 | BMH21 | DNA/RNA Synthesis |
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. | |||
T16750 | Rigosertib | ON-01910 | Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src |
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina... | |||
T5818 | Rigosertib sodium | Rigosertib,Estybon,ON-01910 | Apoptosis , PLK , PI3K |
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3. | |||
T28765 | SFOM-0046 | SFOM 0046 | |
SFOM-0046 is an anticancer agent. SFOM-0046 arrests the cell cycle in S-phase and causes DNA replication stress, resulting in the phosphorylation of H2AX into gamma-H2AX. | |||
T63654 | OTS186935 hydrochloride | ||
OTS186935 hydrochloride is a potent inhibitor of the protein methyltransferase SUV39H2 (IC50: 6.49 nM). oTS186935 hydrochloride significantly inhibited tumor growth in a mouse xenograft model with no apparent toxicity. o... | |||
T28648 | S39625 | S-39625,S 39625 | |
S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and pers... | |||
T73225 | OTS193320 | ||
OTS193320, an imidazopyridine compound, acts as an inhibitor of SUV39H2 methyltransferase activity. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, promoting apoptotic cel... | |||
T64022 | Antitumor agent-37 | ||
Antitumor agent-37 exhibits potent anti-proliferative and anti-metastatic effects. antitumor agent-37 induces severe DNA damage, leading to high expression of γ-H2AX and p53. antitumor agent-37 induces apoptosis by explo... | |||
T74393 | Antitumor agent-36 | ||
Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochond... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01319 | EYA2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes... | |||
TMPH-01621 | BRCC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes... | |||
TMPH-01267 | RNF13 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein... | |||
TMPH-01273 | TRIP12 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a... |