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カタログ番号 | 製品名 | 別名 | ターゲット |
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T0192 | Levetiracetam | UCB L059,SIB-S1 | DNA Methyltransferase , Others , Calcium Channel |
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... | |||
T77334 | HDAC-IN-57 | Apoptosis , HDAC | |
HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ... | |||
T67878 | HDAC-IN-52 | HDAC | |
HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research. | |||
T8508 | HDAC-IN-3 | GSK3117391A | HDAC |
HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. | |||
T69753 | HDAC6 degrader 9c | HDAC | |
HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases. | |||
T2025 | HDAC-IN-7 | HBI-8000,CS055,Chidamide impurity | HDAC |
HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10). | |||
T60082 | HDAC-IN-40 | HDAC | |
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects | |||
T63399L | MTOR/HDAC-IN-1 HCl | mTOR/HDAC-IN-1 HCl(2815286-02-1 Free base) | HDAC , mTOR |
mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research. | |||
T24131 | HDAC3-IN-T247 | HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247 | Histone Demethylase , Antiviral |
HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i... | |||
T73181 | HDAC-IN-51 | HDAC | |
HDAC-IN-51 is an HDAC inhibitor. | |||
T50084 | HDAC1/5-IN-1 | Others | |
(2E)-N-(4-methoxyphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enamide is a compound used as a molecular structural unit. | |||
T24133 | HDAC8-IN-20a | HDAC8 IN 20a,HDAC8IN20a,HDAC8 inhibitor-20a,HDAC8 inhibitor 20a | HDAC |
HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals. | |||
T19353 | HDAOS | Others | |
HDAOS is a novel Trinder's reagent, which is a highly water-soluble aniline derivative. HDAOS is widely used in diagnostic tests and biochemical tests. | |||
T7082 | HDAC8-IN-1 | HDAC | |
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ... | |||
T63260 | Snail/HDAC-IN-1 | Apoptosis , Antifungal | |
Snail/HDAC-IN-1 is a Snail/HDAC inhibitor agent with antimicrobial and anticancer activity, reduces Snail protein expression, induces apoptosis, and can be used in the study of solid tumors. | |||
T72872 | HDAC/BET-IN-1 | HDAC | |
HDAC/BET-IN-1 is a chemical compound exhibiting submicromolar inhibitory activity against HDAC1 and HDAC6, with IC50 values of 0.163 μM and 0.067 μM, respectively, and against BRD4, with a Ki of 0.076 μM. Additionally, i... | |||
T11625 | IDO1 and HDAC1 Inhibitor | Others | |
IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM). | |||
T79771 | HDAC6-IN-22 | HDAC | |
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and in vivo. It induces cell cycle arrest in the G2 phase and p... | |||
T78769 | HDAC6-IN-17 | HDAC | |
HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is ut... | |||
T78861 | HDAC8-IN-5 | HDAC | |
HDAC8-IN-5 (Compound 6a), with an inhibitory concentration (IC50) of 28 nM, is a potent HDAC8 inhibitor suitable for cancer research [1]. | |||
T79768 | HDAC/JAK/BRD4-IN-1 | Epigenetic Reader Domain | |
HDAC/JAK/BRD4-IN-1 (compound 25ap) is a potent triple inhibitor targeting HDAC, JAK, and BRD4. This compound not only inhibits cell proliferation but also induces apoptosis in MDA-MB-231 cells and demonstrates in vivo an... | |||
T78532 | HDAC-IN-55 | Others | |
HDAC-IN-55(8j) is a small-molecule inhibitor that enhances E-cadherin expression and suppresses cancer cell proliferation [1]. | |||
T79674 | HDAC-IN-64 | HDAC | |
HDAC-IN-64 (Compound 13), an HDAC inhibitor, demonstrates potent inhibition of HDAC4/5/6/7/9 with IC50 values of 24, 45, 85, 31, and 37 nM, respectively. It exhibits anti-proliferative and anti-migration effects on prost... | |||
T79713 | JMJD3/HDAC-IN-1 | HDAC | |
Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone deacetylase, IC50 = 16 nM). It induces hypermethylation of his... | |||
T78799 | BChE/HDAC6-IN-1 | HDAC | |
BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42... | |||
T78768 | HDAC6-IN-16 | HDAC | |
HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing... | |||
T79710 | PI3Kα/HDAC6-IN-1 | HDAC | |
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated... | |||
T60794 | HDAC10-IN-1 | Others | |
HDAC10-IN-1 (compound 13b) is a potent and highly selective inhibitor of HDAC10 (IC 50 = 58 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1]. | |||
T63696 | HDAC-IN-9 | Others | |
HDAC-IN-9 is a potent and selective dual inhibitor of tubulin and HDAC. HDAC-IN-9 exhibits inhibitory effects on the invasion and migration of A549 cells. HDAC-IN-9 exhibits potent anti-tumor and anti-angiogenic activiti... | |||
T63422 | HDAC-IN-45 | Others | |
HDAC-IN -45, a small molecule HDAC inhibitor, was able to form hydrogen bonds with Y303 residues and exhibited anticancer effects. HDAC-IN-45 significantly inhibited HDAC1, HDAC2 and HDAC3 subtypes with their IC50 values... | |||
T36625 | LSD1/HDAC6-IN-1 | LSD1/HDAC6-IN-1 | Others |
LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ... | |||
T72777 | C-Met/HDAC-IN-3 | Others | |
c-Met/HDAC-IN-3, a dual inhibitor targeting both c-Met and HDAC, exhibits potent inhibitory activity with IC50 values of 12.50 nM for c-Met and 26.97 nM for HDAC1. It induces apoptosis and causes cell cycle arrest in the... | |||
T64187 | HDAC1/6-IN-1 | Others | |
HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can b... | |||
T78818 | HDAC-IN-63 | Others | |
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1. It effectively suppresses MV4-11 cell proliferation with an IC50 of 92 nM, induces apoptosis, and arrest... | |||
T63142 | AChE/HDAC-IN-1 | Others | |
COX-2-IN-23 (compound A10) is a potent inhibitor of AChE (IC50: 0.12 nM) and HDAC (IC50: 0.23 nM).COX-2-IN-23 exhibits antioxidant and metal chelating properties.COX-2-IN-23 can be used to study Alzheimer's disease. | |||
T63509 | Top/HDAC-IN-1 | Others | |
Top/HDAC-IN-1 is a dual topoisomerase (Top)/HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM). Top/HDAC-IN-1 exhibited potent antit... | |||
T75017 | PROTAC HDAC6 degrader 1 | Others | |
Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1]. | |||
T61962 | PARP-1/HDAC-IN-1 | Others | |
PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities. | |||
T62912 | PI3K/HDAC-IN-2 | Others | |
PI3K/HDAC-IN-2 is a potent dual PI3K/HDAC inhibitor, capable of acting on PI3Kα (IC50: 226 nM), PI3Kβ (IC50: 279 nM), PI3Kγ (IC50: 467 nM), PI3Kδ (IC50: 29 nM), HDAC1 (IC50: 1.3 nM), and PI3K/HDAC-IN-2 is PI3Kδ and class... | |||
T62920 | HDAC-IN-38 | Others | |
HDAC-IN-38 is a potent inhibitor of HDAC. HDAC-IN-38 has similar micromolar inhibitory effects on HDAC1, 2, 3, 5, 6 and 8, and also increases histone acetylation levels (H3K14 or H4K5). HDAC-IN-38 increases cerebral bloo... | |||
T63791 | HDAC-IN-36 | Others | |
HDAC-IN-36 is an orally active HDAC (histone deacetylase) inhibitor with an IC50 value of 11.68 nM for HDAC6. HDAC-IN-36 induces apoptosis, autophagy and inhibits migration. HDAC-IN-36 exhibits antitumor and antimetastat... | |||
T73031 | HDAC6-IN-14 | Others | |
HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1, HDAC2, HDAC3, and HDAC4. | |||
T39567 | HDAC1/2-IN-3 | HDAC1/2-IN-3 | Others |
HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively. | |||
T62644 | HDAC-IN-41 | Others | |
HDAC-IN-41 (Compound 7c) is an orally active, selective class I HDAC inhibitor that acts on HDAC1 (IC50: 0.62 μM), HDAC2 (IC50: 1.46 μM) and HDAC3 (IC50: 0.62 μM). HDAC-IN-41 shows NO-releasing activity. | |||
T61044 | HDAC6-IN-11 | Others | |
HDAC6-IN-11 (Compound 9) has anti-proliferative activities against cancer cells. HDAC6-IN-11 is a selective inhibitor of HDAC6 with the IC50 value of 20.7 nM. The selectivity of HDAC6-IN-11 is more than 300-fold over HDA... | |||
T60856 | HDAC6-IN-9 | Others | |
HDAC6-IN-9 (compound 12c) is a potent and selective inhibitor of HDAC6 with anti-proliferative activities. The IC 50 values of HDAC6-IN-9 for HDAC6, HDAC1,HDAC3, HDAC8, and HDAC10 is 4.2, 11.8, 15.2, 139.6, and 21.3 nM, ... | |||
T62717 | A2AAR/HDAC-IN-2 | Others | |
A2AAR/HDAC-IN-2 is a potent dual A2AAR/HDAC inhibitor.A2AAR/HDAC-IN-2 shows good affinity for A2AAR (Ki:10.3 nM) and inhibits HDAC1 well (IC50:18.5 nM). A2AAR/HDAC-IN-2 can be used in anti-tumour studies. | |||
T62046 | HDAC6-IN-5 | Others | |
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated inhibitor of HDAC6 (IC50= 0.025 μM). HDAC6-IN-5 inhibits Aβ 1-42 self-aggregation and AChE, with IC 50s of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowt... | |||
T61139 | HDAC6-IN-3 | Others | |
HDAC6-IN-3 (Compound 14) is a potent anti-prostate cancer agent that acts as an orally active inhibitor of HDAC6. It has IC50 values ranging from 0.02-1.54 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10. Additional... | |||
T72759 | C-Met/HDAC-IN-2 | Others | |
c-Met/HDAC-IN-2 is a potent dual inhibitor of c-Met and HDAC, exhibiting IC50 values of 5.40 nM for c-Met and 18.49 nM for HDAC1, respectively. It demonstrates antiproliferative effects on various cancer cell lines, indu... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01333 | HDAC8 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1. | |||
TMPY-03431 | HDAC4 Protein, Human, Recombinant (aa 612-1084) | Human | Baculovirus Insect Cells |
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups ... | |||
TMPH-01471 | HDAC1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
HDAC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.1 kDa and the accession number is Q13547. | |||
TMPH-01474 | HDAC6 Protein, Human, Recombinant (His) | Human | E. coli |
HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01475 | HDAC7 Protein, Human, Recombinant (His) | Human | E. coli |
N/A. HDAC7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26 kDa and the accession number is Q8WUI4 (BC064840). | |||
TMPH-01476 | HDAC9 Protein, Human, Recombinant (His) | Human | E. coli |
HDAC9 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-02317 | HDAC8 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
HDAC8 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 43.1 kDa and the accession number is Q8VH37-1. | |||
TMPH-01473 | HDAC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
HDAC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.8 kDa and the accession number is O15379. | |||
TMPH-01472 | HDAC11 Protein, Human, Recombinant (GST) | Human | E. coli |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcrip... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TMIH-0260 | HDAC-IN-4-d4 | ||
HDAC-IN-4-d4 is a deuterated compound of HDAC-IN-4. |