検索結果

Search Results for " IP3 "

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T30935	Ci-IP3/PM
	CI-IP3 /PM is a cell-permeable caged inositol triphosphate that promotes the release of Ca2+ from internal storage under UV photolysis.
T19266	Ins(1,4,5)-P3 hexapotassium salt	1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt	Others
	D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.		Others
T8867	RO2959 Hydrochloride	RO2959 HCl	IL Receptor , Calcium Channel , Interleukin
	RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.		IL Receptor , Calcium Channel , Interleukin
T41181	iP300v
	iP300v is a negative control for iP300w
T68759	OSIP339391
	OSIP339391 is a A2BAR antagonist.
T83733	TIP39 (human, bovine) TFA	Tuberoinfundibular Peptide of 39 Residues
	TIP39, a neuropeptide and an agonist for the parathyroid hormone receptor type 2 (PTH2R), effectively increases cAMP levels in COS-7 cells featuring recombinant PTH2R from humans or rats (EC50s = 0.5 and 0.8 nM, respecti...
T4693	2-Aminoethyl diphenylborinate	2-Aminoethoxydiphenyl borate,2-APB	Calcium Channel , TRP/TRPV Channel
	2-Aminoethyl diphenylborinate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).		Calcium Channel , TRP/TRPV Channel
T11137	(E)-GABAB receptor antagonist 1		GABA Receptor
	(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM. GABAB receptor antagonist 1 is ...		GABA Receptor
T9031	MCU-i4		Others , Mitochondrial Metabolism
	MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.		Others , Mitochondrial Metabolism
TP1710	Calmodulin Binding Peptide 1
	Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced ...
T14202	AM-4668		GPR
	AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respectively.		GPR
T83950	ARN 11391
	ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ion signaling by directly targeting ITPR1. Furthermore, ARN 1139...
T11350	GABAB receptor antagonist 1		GABA Receptor
	(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric ac...		GABA Receptor
T37030	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dio...
T14553	BHPI		Others
	BHPI is a potent ERα inhibitor that blocks nuclear estrogen–ERα-regulated gene expression effectively. It triggers sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded...		Others
T36937	PtdIns-(1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl...

Compounds

Ins(1,4,5)-P3 hexapotassium salt

T19266

Synonym: 1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt

Target: IL Receptor, Calcium Channel, Interleukin

TIP39 (human, bovine) TFA

T83733

Synonym: Tuberoinfundibular Peptide of 39 Residues

Target:

2-Aminoethyl diphenylborinate

T4693

Synonym: 2-Aminoethoxydiphenyl borate,2-APB

Target: Calcium Channel, TRP/TRPV Channel

(E)-GABAB receptor antagonist 1

T11137

Synonym:

Target: GABA Receptor

MCU-i4

T9031

Synonym:

Target: Others, Mitochondrial Metabolism

Calmodulin Binding Peptide 1

GABAB receptor antagonist 1

T11350

Synonym:

Target: GABA Receptor

PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

T37030

Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

PtdIns-(1,2-dioctanoyl) (sodium salt)

T36937

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T7190	Actein		Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...		Apoptosis , Akt , JNK , Autophagy
T23538	Xestospongin C	(-)-Xestospongin C	Others
	IP3-dependent Ca2+ release inhibitor		Others

天然物製品

Actein

T7190

Synonym:

Target: Apoptosis, Akt, JNK, Autophagy

Xestospongin C

T23538

Synonym: (-)-Xestospongin C

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02537	BNIP3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	BNIP3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.6 kDa and the accession number is O55003.
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPH-02536	BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)	Mouse	E. coli
	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality cont...
TMPH-03096	Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc)	Phleum pratense	E. coli
	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the forma...
TMPH-01715	CHRM2 Protein, Human, Recombinant (His)	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPJ-00943	Profilin 2 Protein, Human, Recombinant	Human	E. coli
	Profilin-II (PFN2) is ubiquitous protein which belongs to the profilin family. PFN2 binds to actin, thenaffects the structure of the cytoskeleton. At high concentrations, profiling prevents the polymerization of actin, w...
TMPY-03657	Profilin 2 Protein, Human, Recombinant (His)	Human	E. coli
	Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and l...