|
T9119 |
SU0268
|
|
Others
|
|
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection. |
|
TD0099 |
Malachite green oxalate
|
|
Apoptosis
,
Others
,
IκB/IKK
,
NF-κB
|
|
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. |
|
T5317 |
Cridanimod
|
CMA,XBIO-101,10-carboxymethyl-9-acridanone |
Progesterone Receptor
,
STING
,
IFNAR
|
|
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
|
T7081 |
CCCP
|
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone |
Apoptosis
,
IκB/IKK
,
COX
,
Mitochondrial Metabolism
,
STING
,
IFNAR
,
Antibacterial
|
|
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ... |
|
T0097 |
MRT67307
|
MRT67307 HCl |
IκB/IKK
,
Autophagy
|
|
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage... |
|
T6285 |
GSK-690693
|
GSK690693 |
Serine Protease
,
Akt
,
PKC
,
AMPK
,
Autophagy
|
|
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1. |
|
T4027 |
KIN1148
|
|
Influenza Virus
|
|
KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an ... |
|
T27732 |
KIN1400
|
|
|
|
KIN1400, a novel IRF3 activator, triggers IRF3-dependent innate immune antiviral genes and IFNbeta307 expression, suppresses WNV, DV infection, and HCV replication. |
|
T81082 |
STING-IN-7
|
|
STING
|
|
STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of 11.5 nM. It effectively hampers the phosphorylation of both... |
|
T83047 |
Anti-inflammatory agent 65
|
|
STING
|
|
Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation of IRF3 and p65, and disrupting the STING/IRF3/NF-κB signal... |
|
T10642 |
C-di-AMP
|
Cyclic diadenylate,Cyclic-di-AMP |
Others
|
|
c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. |
|
T75092 |
STING agonist-24
|
|
|
|
STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-... |
|
T75093 |
STING agonist-25
|
|
|
|
STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and ... |
|
T75096 |
STING agonist-28
|
|
|
|
STING agonist-23 (CF510) is a non-nucleotide, small-molecule activator of the STING pathway. It initiates the phosphorylation of STING, TBK1, and IRF3, enhancing the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and... |
|
T75091 |
STING agonist-23
|
|
|
|
STING agonist-23 (CF502) is a non-nucleotide, small-molecule stimulator of the STING pathway. Upon activation, it enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of IFN-β, IL-6, CXCL-10,... |
|
T72615 |
STING modulator-4
|
|
|
|
STING Modulator-4 is a competitive modulator of STING, exhibiting a K_i value of 0.0933 μM for the R232H STING variant. It demonstrates an EC_50 of over 10 μM for p-IRF3 activation in THP-1 cells. |
|
T75094 |
STING agonist-26
|
|
|
|
STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T... |
|
T36461 |
CAY10748
|
CAY10748 |
|
|
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, re... |
|
T83901 |
BDW568
|
|
|
|
BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value ... |
|
T73873 |
C-di-AMP disodium
|
|
|
|
Cyclic diadenylate (c-di-AMP) sodium functions as a STING agonist by binding to the STING transmembrane protein, thus activating the TBK3-IRF3 signaling pathway. This activation prompts the production of type I IFN and T... |
|
T23028 |
MRT67307 HCl (1190378-57-4 free base)
|
MRT67307 HCl |
Others
|
|
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i... |
|
T38161 |
STING Agonist C11
|
STING Agonist C11 |
|
|
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory... |
|
T83841 |
STING Agonist D61
|
D61,Stimulator of Interferon Genes Agonist D61 |
|
|
STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular as... |
|
T38263 |
TBK1/IKKε-IN-4
|
TBK1/IKKε-IN-4 |
|
|
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced ... |
