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カタログ番号 | 製品名 | 別名 | ターゲット |
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T60011 | HS220 | MAPK | |
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival. | |||
T3350 | Selonsertib | GS-4997 | Apoptosis , ASK , MAPK |
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. | |||
T3101 | NQDI-1 | NQDI1,NQDI 1 | Apoptosis , ASK , MAPK |
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM). | |||
T5190 | GS-444217 | GS 444217,GS444217 | Apoptosis , ASK , MAPK |
GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM). | |||
T5643 | NG25 | MAPK | |
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively. | |||
T9377 | ASK1-IN-2 | Apoptosis , ASK , MAPK | |
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis[1]. | |||
T13099 | TC ASK 10 | ASK , MAPK | |
T16987 | TAO Kinase inhibitor 1 | Others , MAPK | |
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectiv... | |||
T3707 | GNE-3511 | GNE3511 | DNA Alkylation , MAPK |
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors. | |||
T4264 | Takinib | EDHS-206 | Apoptosis , MAPK |
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM). | |||
T69894 | MAP3K14-IN-173 | ||
MAP3K14-IN-173 is a potent MAP3K14 kinase inhibitor. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T14055 | 5Z-7-Oxozeaenol | FR148083,L783279,LL-Z 1640-2 | VEGFR , FLT , MEK , MAPK , PDGFR , Antibiotic , Src |
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is ... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01693 | MAP3K14 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-ka... | |||
TMPY-04389 | MAP3K8 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ... | |||
TMPY-05095 | RAF1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct... |