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T11995 |
Melatonin-d4
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N-Acetyl-5-methoxytryptamine D5,Melatonin D5 |
Others
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Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulatio... |
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T64745 |
Melatonin Biotin
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Melatonin Biotin is a useful organic compound for research related to life sciences and the catalog number is T64745. |
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T60490 |
Melatonin receptor agonist 1
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Melatonin receptor agonist 1 (compound 20c) is a potent agonist of melatonin receptor (MT) with Ki values of 108 nM for MT2 and 1140 nM for MT 1 [1]. |
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T14042 |
4-P-PDOT
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4-phenyl-2- propionamidotetralin |
Melatonin Receptor
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MT Receptor
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4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist. |
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T9193 |
ACH-000143
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Melatonin Receptor
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MT Receptor
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ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
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T8600 |
N-ACETYLTRYPTAMINE
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Melatonin Receptor
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N-ACETYLTRYPTAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase. |
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T1463 |
Ramelteon
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TAK-375 |
Melatonin Receptor
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MT Receptor
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Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
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T15795 |
Luzindole
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N-0774 |
Melatonin Receptor
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MT Receptor
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Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1... |
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T3495 |
Tasimelteon
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VEC-162,BMS-214778 |
Melatonin Receptor
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MT Receptor
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Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. |
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T1445 |
Agomelatine
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Thymanax,S-20098,Valdoxan |
Melatonin Receptor
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5-HT Receptor
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Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. |
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T16834 |
S26131
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N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
MT Receptor
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S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively. |
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T22530 |
6-Chloromelatonin
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Melatonin Receptor
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Dopamine Receptor
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6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... |
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T10073 |
2-Iodomelatonin
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Melatonin Receptor
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2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind... |
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T10929L |
D-3263 hydrochloride
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EC D-3263 HCl,D3263 HCl salt |
TRP/TRPV Channel
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D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist. |
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T41345 |
AFMK
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Formyl-N-acetyl-5-methoxykynurenamine,Acetyl-N-formyl-5-methoxykynurenamine |
Apoptosis
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Free radical scavengers
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Antioxidant
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Endogenous Metabolite
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AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine ... |
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T10198 |
8-M-PDOT
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8-Methoxy-2-propionamidotetralin,AH-002 |
MT Receptor
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T34081 |
Piromelatine
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NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
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5-HT Receptor
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MT Receptor
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Sodium Channel
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TRP/TRPV Channel
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Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
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T28644 |
S20928
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S 20928,S-20928 |
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S20928 is an antagonist of melatonin receptor. |
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T28645 |
S-22153
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S22153 is an antagonist of melatonin receptor. |
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T29044 |
UCM 765
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UCM-765,UCM765 |
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UCM 765 is a partial agonist of melatonin MT(2) receptor. |
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T22499 |
UCM 608
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2-Phenylmelatonin |
Others
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melatonin agonist |
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T69409 |
DH-97
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DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03). |
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T22721 |
DH97
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DH 97 |
Others
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MT2 melatonin receptor antagonist |
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T27430 |
GR 196429
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GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429 |
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GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice. |
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T27429 |
GR 128107
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GR128107,GR-128107 |
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GR 128107 is an antagonist of melatonin receptor. |
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T13707 |
Pareptide monohydrochloride
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Others
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Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF). |
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TMIH-0486 |
Ramelteon-d5
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Ramelteon-d5 is a deuterated compound of Ramelteon. Ramelteon has a CAS number of 196597-26-9. Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
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TMIH-0485 |
Ramelteon-d3
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Ramelteon-d3 is a deuterated compound of Ramelteon. Ramelteon has a CAS number of 196597-26-9. Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
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T10929 |
D-3263
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Others
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D-3263 is an agonist of transient receptor potential melatonin member 8 (TRPM8) with potential antitumor activity. |
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T12689 |
Ramelteon metabolite M-II
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Others
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Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin. |
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T71182 |
N 0745
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N 0745 inhibits 2-[125I]-iodomelatonin binding to median eminence/pars tuberalis membranes with an affinity similar to that of melatonin. |
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T17095 |
TIK-301
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PD-6735,LY-156735 |
5-HT Receptor
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TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an... |
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T21366 |
Sapropterin free base
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BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin |
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Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatoni... |
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T38112 |
DL-Tryptophan octyl ester (hydrochloride)
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Tryptophan is an amino acid precursor of serotonin and melatonin. DL-Tryptophan octyl ester is a tryptophan derivative with an octyl ester protected COOH group. This addition creates a stable, cell-permeable molecule cap... |
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T36176 |
AMK (hydrochloride)
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitro... |
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T33450 |
ML 23
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ML-23,ML23 |
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ML 23 is a melatonin analogue in the treatment and management of Parkinson's disease. ML-23 is a potential clinical candidate for the treatment of PD, and the present study has been undertaken to determine the efficacy o... |
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T71963 |
(−)-WIN 55,212-3 mesylate
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(−)-WIN 55,212-3 mesylate is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 and the inverse agonism ... |
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T73832 |
Tubulin inhibitor 21
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Tubulin Inhibitor 21 (compound 6f), a hybrid based on chalcone and melatonin, exhibits potent tubulin inhibition properties. It demonstrates significant cytotoxic activity against SW480 cells (IC 50 =0.26 μM) while showi... |
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T70035 |
Tasimelteon-d5
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Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... |
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T35993 |
Epitalon (acetate)
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Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalo... |
