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T79577 |
CB2 PET Radioligand 1
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Cannabinoid Receptor
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CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.7 nM). It is synthesized via Cu-mediated 18F-fluorination an... |
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T21667 |
FAUC-365
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FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-
phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide |
Dopamine Receptor
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FAUC-365 is a D3 dopamine receptor agonist. |
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T11894 |
Lusaperidone
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R107474 |
Adrenergic Receptor
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Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively. |
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T16140 |
MRS 1754
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Adenosine Receptor
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MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats. |
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T38205 |
3-Aminopropylphosphonic Acid
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GABA Receptor
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3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). |
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T30140 |
Arotinolol hydrochloride
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Arotinolol HCl |
5-HT Receptor
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Adrenergic Receptor
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Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol h... |
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T16115 |
MLi-2
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LRRK2
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MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce... |
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T34243 |
R214127
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R 214127,R-214127 |
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R214127 is a new type of mGlu1 receptor high-affinity radioligand. |
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T30253 |
AZD-2184
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J2.698.897G,AZD2184 |
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AZD-2184 is a radioligand for detecting beta-amyloid deposits. |
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T34626 |
Setoperone
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R-52245,R 52245,R52245 |
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Setoperone, as a sensitive radioligand, can be commonly used in position emission tomography (PET) imaging. |
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T29913 |
Altanserin
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R-53200,R53200,R 53200 |
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Altanserin can binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain. |
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T34483 |
Sadopine
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Sadopine is an excellent high affinity, high specific activity radioligand to label selectively the DHP receptor of L-type Ca2+ channels in tissue sections as well as in membrane fragments. |
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T26478 |
A-317920
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A-317920 is an inverse agonist radioligand. |
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T10371 |
Arotinolol
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5-HT Receptor
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Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is... |
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T39069 |
UCB-J
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UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4]. |
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T71186 |
ORM-13070
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ORM-13070 is a selective antagonist radioligand for the α2C adrenoceptor subtype. ORM-13070 C-11 is under investigation in clinical trial. |
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T34688 |
SP203
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SP-203,SP 203 |
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SP203 is a radioligand for brain metabotropic glutamate receptor imaging. |
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T33277 |
Mefway F-18
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18F-Mefway |
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Mefway F-18 is a PET radioligand specific to serotonin-1A receptors. |
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T69100 |
A-349821
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A-349821 is an H3 receptor agonist radioligand. |
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T70459 |
BMT-046091
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BMT-046091 is a potent and selective radioligand which inhibits adaptor-associated kinase 1 (AAK1). |
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T27494 |
GSK931145
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GSK 931145,GSK-931145 |
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GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain. |
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T38171 |
Ro 1138452 hydrochloride
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Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailabl... |
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T38162 |
STING18
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STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β productio... |
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T28335 |
PD 140376
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PD-140376,PD140376 |
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PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems. |
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T38787 |
ER176
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ER176 is a novel PET radioligand utilized for the visualization of 18 kDa translocator protein (TSPO), a neuroinflammation biomarker, marking the advancement in imaging technology. |
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T29913L |
Altanserin tartrate
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R-53,200 |
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Altanserin tartrate is a compound that binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain. |
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T19690 |
SB 224289
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SB224289,SB-224289 |
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SB 224289 is a selective antagonist of 5-HT1B receptor with pKi of 8.2. It is a centrally active following oral administration in vivo. SB 224289 displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A a... |
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T70615 |
TAS-303
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TAS-303 is a selective norepinephrine reuptake inhibitor which displays significant norepinephrine transporter (NET) inhibitory activity toward serotonin or dopamine transporters. Radioligand-binding studies showed that ... |
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T38289 |
Leucomycin A13
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Leucomycin A13 |
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Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0... |
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T27455 |
GSK-215083
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GSK215083 |
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GSK-215083 is a PET radioligand for the 5-HT6 receptor. GSK 215083 is a quinoline based compounds and acts by antagonising the 5-HT6 receptor. GSK-215083 binds to receptors 5-hydroxytrypamine-6 (5HT6) in the striatum and... |
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T38223 |
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
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N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxis... |
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T16547 |
PK14105
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Others
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PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilate... |
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T29742 |
AH-9700 free base
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AH-9700 free base is use for treatment of urge incontinence and pollakiuria.In a radioligand binding study,AH-9700 free base showed high affinities for sigma receptors and it produces a marked inhibitory effect on the mi... |
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T62141 |
RBP4 ligand-1
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RBP4 ligand-1 is a non-retinoid ligand for retinol-binding protein 4 (RBP4). hRBP4SPAIC50 and RBP4-TTR FRET IC50 values were 0.23±0.11 and 0.13±0.12 μM for the radioligand binding assay and FRET assay, respectively. 0.12... |
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T35591 |
Guanfacine-13C,15N3
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Guanfacine-13C,15N3 |
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Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A... |
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T78927 |
PSMA-IN-3
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PSMA-IN-3 (compound 17) is a novel, high-affinity inhibitor of Prostate-Specific Membrane Antigen (PSMA) with an inhibitory concentration (IC50) of 13 nM, showing potential for the development of an 18F-labeled radioliga... |
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T37131 |
MS 15203
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Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re... |
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T72999 |
PF-06455943
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PF-06455943, a leucine rich repeat kinase 2 (LRRK2) inhibitor, exhibits an inhibition concentration (IC50) value of 3 nM and also functions as a PET radioligand. It is utilized in the research of ADME/neuro PK characteri... |
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T16443 |
PCS1055 dihydrochloride
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Others
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T37167 |
Reduced Haloperidol
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Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4... |
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T75145 |
TRV-7019
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TRV-7019 is a butyrylcholinesterase-targeting radioligand capable of penetrating the blood-brain barrier (BBB) for brain imaging. It is utilized for diagnosing conditions such as amyloid diseases, multiple sclerosis, bra... |
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T73711 |
Atomoxetine-d3 hydrochloride
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Atomoxetine-d3 hydrochloride, the deuterium-labeled form of Atomoxetine hydrochloride, acts as a potent and selective noradrenalin re-uptake inhibitor with Ki values of 5, 77, and 1451 nM for the inhibition of radioligan... |
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T36204 |
Methylatropine (nitrate)
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Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induce... |
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T37212 |
5-hydroxy-Nω-methyl Tryptamine (oxalate)
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5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-me... |
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T31828 |
AZD4694
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Flutafuranol,AZD 4694,NAV-4694,AZD-4694,NAV 4694,NAV4694 |
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Flutafuranol, also known as AZD 4694 and NAV4694, is a bio-active chemical. AZD4694 shows high affinity for beta-amyloid fibrils in vitro (K(d) = 2.3 +/- 0.3 nM). The fluorine-18 labeled AZD4694 may have potential for PE... |
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T37492 |
11-trans Leukotriene C4
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11-trans Leukotriene C4 |
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11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative... |
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T35772 |
Emestrin
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Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacter... |
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T36722 |
Deltorphin II (trifluoroacetate salt)
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Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [3... |
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T83956 |
CELT-133
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CELT-133 is a selective fluorescent antagonist for the hα1A adrenergic receptor, demonstrating complete selectivity towards α1A over α2A receptors, with a Ki of 5 nM and 15% displacement at 1 μM in radioligand binding as... |
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T83957 |
CELT-211
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CELT-211 is a potent, selective fluorescent ligand for the h5HT2B serotonin receptor, demonstrating full selectivity over h5HT2A and h5HT2C receptors with a Ki value of 56.3 nM in radioligand binding assays for h5HT2B re... |
