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Search Results for " TGFβ "

ターゲット

30

阻害剤

25

リコンビナントタンパク質

2

ライブラリー

カタログ番号 製品名 別名 ターゲット
T77786 TGFβ-IN-5 WAY-641966 TGF-beta/Smad
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.
T60596 TGFβ-IN-1
TGFβ-IN-1 is an antitumor growth and metastasis agent by inhibiting the transforming growth factor β signaling pathway.
T61586 TGFβ-IN-2
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and ...
T21714 BMS453 BMS 453,BMS-189453 Retinoid Receptor
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
T6496 Vactosertib TEW-7197,EW-7197 ALK , TGF-beta/Smad
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...
T9523 TGFβRI-IN-3 TGF-beta/Smad
TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1].
T75005 TGFβ1-IN-3 Others
TGFβ1-IN-3 is a diarylhydrazone derivative with inhibitory effects on fibroblast activation and proliferation.TGFβ1-IN-3 is a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF).
T61389 TGFβ1-IN-1 TGF-beta/Smad
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases.
T75004 TGFβ1-IN-2 Others
TGFβ1-IN-2, a derivative of diarylacylhydrazones, effectively inhibits fibroblast activation and proliferation and holds potential for idiopathic pulmonary fibrosis (IPF) research [1].
T13137 TGFβRI-IN-1 TGF-beta/Smad
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ).
T62559 TGFβRI-IN-4
TGFβRI-IN-4 is a potent, orally active TGFβ receptor type I kinase (TGFβRI) inhibitor that acts on ALK5 (IC50: 44 nM) and NIH3T3 (IC50: 42.5 nM).TGFβRI-IN-4 inhibits tumor growth and tumor weight in a xenograft tumor mod...
T72976 TGFβRI-IN-6
TGFβRI-IN-6 is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM.TGFβRI-IN-6 has the potential to enhance anti-tumour immunity.
T60931 TGFβRI-IN-5
TGFβRI-IN-5 (Compound 4b) is a potent TGFβRI inhibitor with an IC50 of 0.08 μM. TGFβRI-IN-5 shows amazing anticancer activity against all the tested cell lines which enhances apoptosis and arrested G2/M phase of cell cyc...
T74163 TGFβR-IN-1
TGFβR-IN-1 is a long-acting tumor-activated proagent of a TGFβR inhibitor.
T2273 ITD-1 TGF-beta/Smad
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T5197 BIBF0775 ALK , TGF-beta/Smad
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T61301 Chromenone 1 TGF-beta/Smad
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
T35896 AZ 12799734 AZ12799734 ALK
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.
T2247 KenPaullone 9-Bromopaullone,NSC-664704 GSK-3 , CDK
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...
T8730 BMS986260 TGF-beta/Smad
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
T10444 TAK1/MAP4K2 inhibitor 1 Others
TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor of TGFβ-activated kinase 1 (TAK1) and MAP4K2 (IC50s: 41.1 nM and 18.2 nM).
T70334 SRI-31277
SRI-31277 is a TSP1-TGFβ inhibitor.
T26280 TL4-12 TL4 12
TL4-12 is a MAP4K2 (GCK) inhibitor that inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro.
T73016 THRX-144644
THRX-144644, a lung-restricted ALK5 inhibitor, exhibits a potent IC50 value of 0.14 nM and circumvents systemic toxicities linked to TGFβ pathway inhibition.
T62615 ALK5-IN-30
ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).
TP2147 LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) Others
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, a latency-associated protein (LAP)-TGFβ derived tetrapeptide, is a competitive antagonist of TGF-β1.
T41151 K34c
K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG ...
T76052 ELA-32(human) TFA
ELA-32(human) TFA is a potent apelin receptor agonist with high affinity, demonstrating an IC50 of 0.27 nM and a Kd of 0.51 nM. This compound does not bind to GPR15 or GPR25. It activates the PI3K/AKT signaling pathway, ...
TP2097 ELA-32(human) ELA-32 (human)
Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein ...
T36779 NG 25 (hydrochloride hydrate)
NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinase...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-05157 TGFBR2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPK-00258 Latent TGF beta 3 Protein, Human, Recombinant (His) Human HEK293
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differen...
TMPY-01133 Latent TGF beta 1 Protein, Human, Recombinant (His) Human HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00772 Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPK-00259 Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differen...
TMPJ-00622 Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) Cynomolgus Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00250 LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activ...
TMPY-05508 TGFBR2 Protein, Human, Recombinant (hFc) Human HEK293
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPY-05810 TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated Human HEK293
TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPY-05521 Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated Human HEK293
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d...
TMPJ-00771 TGF beta 1 Protein, Mouse/Rat, Recombinant Mouse,Rat Human Cells
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differen...
TMPJ-00249 TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-...
TMPJ-00260 Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00256 Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00255 TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPY-02567 PPM1A Protein, Human, Recombinant (His) Human E. coli
Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and ...
TMPY-01663 PPM1A Protein, Mouse, Recombinant (His) Mouse E. coli
Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and ...
TMPJ-00259 TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated Human Human Cells
Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPK-01204 TNFRSF19 Protein, Human, Recombinant (His) Human HEK293
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for na...
TMPK-01203 TNFRSF19 Protein, Human, Recombinant (hFc) Human HEK293
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for na...
TMPY-03649 TGFBR3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. T...
TMPY-02224 TGFBR3 Protein, Mouse, Recombinant (His) Mouse HEK293
Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. T...
TMPJ-00966 GDF-5 Protein, Human, Recombinant Human E. coli
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor...
TMPJ-01290 Neurturin Protein, Human, Recombinant Human E. coli
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Simila...
TMPY-00975 FSTL3 Protein, Mouse, Recombinant (His) Mouse HEK293
Follistatin-like 3 (FLRG/Fstl3) is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. FLRG/Fstl3 is a recently described member of the FST family having an overall str...
TGFBR2 Protein, Human, Recombinant (His)
TMPY-05157
Species: Human
Expression System: Baculovirus-Insect Cells
Latent TGF beta 3 Protein, Human, Recombinant (His)
TMPK-00258
Species: Human
Expression System: HEK293
Latent TGF beta 1 Protein, Human, Recombinant (His)
TMPY-01133
Species: Human
Expression System: HEK293
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPJ-00772
Species: Mouse
Expression System: Human Cells
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00259
Species: Human
Expression System: HEK293
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
TMPJ-00622
Species: Cynomolgus
Expression System: Human Cells
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00250
Species: Human
Expression System: Human Cells
TGFBR2 Protein, Human, Recombinant (hFc)
TMPY-05508
Species: Human
Expression System: HEK293
TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated
TMPY-05810
Species: Human
Expression System: HEK293
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
TMPY-05521
Species: Human
Expression System: HEK293
TGF beta 1 Protein, Mouse/Rat, Recombinant
TMPJ-00771
Species: Mouse,Rat
Expression System: Human Cells
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00249
Species: Human
Expression System: Human Cells
Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00260
Species: Human
Expression System: Human Cells
Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00256
Species: Human
Expression System: Human Cells
TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00255
Species: Human
Expression System: Human Cells
PPM1A Protein, Human, Recombinant (His)
TMPY-02567
Species: Human
Expression System: E. coli
PPM1A Protein, Mouse, Recombinant (His)
TMPY-01663
Species: Mouse
Expression System: E. coli
TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated
TMPJ-00259
Species: Human
Expression System: Human Cells
TNFRSF19 Protein, Human, Recombinant (His)
TMPK-01204
Species: Human
Expression System: HEK293
TNFRSF19 Protein, Human, Recombinant (hFc)
TMPK-01203
Species: Human
Expression System: HEK293
TGFBR3 Protein, Human, Recombinant (His)
TMPY-03649
Species: Human
Expression System: Baculovirus-Insect Cells
TGFBR3 Protein, Mouse, Recombinant (His)
TMPY-02224
Species: Mouse
Expression System: HEK293
GDF-5 Protein, Human, Recombinant
TMPJ-00966
Species: Human
Expression System: E. coli
Neurturin Protein, Human, Recombinant
TMPJ-01290
Species: Human
Expression System: E. coli
FSTL3 Protein, Mouse, Recombinant (His)
TMPY-00975
Species: Mouse
Expression System: HEK293
カタログ番号 製品名
L2192 Anti-Pancreatic Cancer Compound Library

2238 compounds
A unique collection of 2238 pancreatic cancer related compounds can be used in HTS and HCS;
L9810 Anti-Fibrosis Compound Library

1155 compounds
A unique collection of 1155 potential anti-fibrosis compounds, can be used in HTS and HCS;