| TN1933 |
Mitraphylline
|
|
IL Receptor
,
TNF
,
NF-κB
|
|
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils. |
| T5S0658 |
Corynoxine
|
|
Autophagy
|
|
Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway. |
| TN1032 |
Geissoschizine methyl ether
|
|
5-HT Receptor
|
|
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and ca... |
| TQ0258 |
Corynoxine B
|
|
Autophagy
|
|
Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese). |
| TN5200 |
Uncarine A
|
|
Others
|
|
Uncarine A is a natural product from Uncaria hirsuta. |
| TN2394 |
1,2-O-Isopropylidene-β-D-fructopyranose
|
|
Others
|
|
1,2-O-Isopropylidene-β-D-fructopyranose is a natural product from Uncaria sessilifructus |
| TN2902 |
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
|
|
Others
|
|
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a natural product from Uncaria sessilifructus. |
| TN5199 |
Uncaric acid
|
|
Others
|
|
Uncaric acid is a natural product of Uncaria, Rubiaceae. The catalog number is TN5199 and the CAS number is 123135-05-7. Uncaric acid can be used as a reference standard. |
| T75438 |
Corynoxine hydrochloride
|
|
|
|
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer. It facilitates the removal of alpha-synuclein by activating the Akt/mT... |
| TN1065 |
Hirsutine
|
|
Apoptosis
|
|
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti... |
| T6S0659 |
Rhynchophylline
|
Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel
,
NF-κB
|
|
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c... |
| T6S0653 |
Linarin
|
Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine |
TNF
,
AChE
|
|
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat... |
| T6S0655 |
Corynoxeine
|
|
ERK
|
|
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty. |
| T6S0657 |
Isorhynchophylline
|
IsoRhy,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline |
Others
|
|
1. Isorhynchophylline (7-Isorhyncophylline) and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of an... |
| TN1081 |
Hirsuteine
|
|
Dopamine Receptor
|
|
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes. |
| TN4884 |
Quinovic acid 3-O-(6-deoxy-beta-D-glucopyranoside) 28-O-beta-D-glucopyranosyl ester
|
|
Others
|
|
Quinovic acid 3-O-(6-deoxy-beta-D-glucopyranoside) 28-O-beta-D-glucopyranosyl ester is a natural product of Uncaria, Rubiaceae. The catalog number is TN4884 and the CAS number is 124727-10-2. Quinovic acid 3-O-(6-deoxy-b... |
| TN2853 |
3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid
|
|
Others
|
|
3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid is a natural product for research related to life sciences. The catalog number is TN2853 and the CAS number is 261768-88-1. |
| TN4921 |
Rubelloside B
|
|
|
|
Rubelloside B exhibits immunological enhancement effect. |
| T5143 |
Corynoxine hydrochloride(6877-32-3(free base))
|
|
Autophagy
|
|
Corynoxine hydrochloride is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. |
