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T38699 |
Piperafizine A
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Piperafizine A is isolated from Streptoverticillium aspergilloides and potentiates vincristine antitumor potency. |
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T10991 |
Dehydronitrosonisoldipine
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Calcium Channel
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T34645 |
Simetride
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Simetride is used in the Reversal of resistance to vincristine in P388 leukemia. |
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T33510 |
MS-073
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CP162398,CP-162398,CP 162398,MS 073 |
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MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, an... |
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T75642 |
Corydalmine hydrochloride
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Corydalmine hydrochloride is a chemical compound that suppresses spore germination in certain plant pathogenic and saprophytic fungi [1], serves as an effective oral analgesic agent with potent activity [2], and mitigate... |
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T26413 |
A 30312
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A-30312,A30312 |
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A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with... |
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T68209 |
Kopsoffinol
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Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine... |
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T63608 |
P-gp inhibitor 5
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P-gp inhibitor 5 is a potent inhibitor of P-glycoprotein (P-gp), inhibiting P-gp by a factor of 2.5 and 3.0 at 1.25 μM and 2.5 μM, respectively. p-gp inhibitor 5 exhibits anti-proliferative effects on some cancer cells. ... |
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T37851 |
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N... |
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T64061 |
Mps1-IN-3 hydrochloride
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Mps1-IN-3 hydrochloride is a potent and selective inhibitor of Mps1 (IC50: 50 nM). mps1-IN-3 hydrochloride exhibits inhibitory effects on the proliferation of glioblastoma cells and effectively sensitizes glioblastomas t... |
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T35616 |
Migrastatin
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Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectiv... |
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T22631 |
Dolastatin 10 trifluoroacetate
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Others
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Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerizati... |
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T71252 |
PC-046
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PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory acti... |
