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T15275 |
Fenobam
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GluR
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Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric mo... |
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T22994 |
ML 154
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Neuropeptide Y Receptor
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neuropeptide S receptor (NPSR) antagonist |
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T8959 |
OS-3-106
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Dopamine Receptor
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OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. |
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T4246 |
Varenicline dihydrochloride
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AChR
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Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist. |
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T28167 |
NGB 2904
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NGB2904 HCl,NGB-2904,NGB2904 |
Others
,
Dopamine Receptor
,
5-HT Receptor
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NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antag... |
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T14767 |
BP 897 hydrochloride
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Dopamine Receptor
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BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ... |
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T10432L |
AZD-8529 mesylate
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GluR
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AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ... |
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T9100 |
BP 897
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2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- |
Dopamine Receptor
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BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 ... |
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T0963 |
Naltrexone hydrochloride
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Depade,Trexan,Naltrexone HCl,Antaxone |
Opioid Receptor
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Naltrexone hydrochloride (Naltrexone HCl) is a synthetic opioid antagonist used in the prevention of relapse of opiate addiction and alcoholism. |
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T61562 |
CB1R Allosteric modulator 3
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cAMP
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Cannabinoid Receptor
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CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction. |
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TP1981L |
Neuropeptide S (Mouse) acetate
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Neuropeptide Y Receptor
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Neuropeptide S (Mouse) acetate is a bioactive peptide. Neuropeptide S (Mouse) acetate, as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behavio... |
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T50112 |
5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine dihydrochloride
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Others
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5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine dihydrochloride is a potent and selective antagonist of metabotropic glutamate receptor 5 (mGluR5). It has been shown to be effective in several neurological disorders, inclu... |
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T0056 |
Oxeladin citrate
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Others
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Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add... |
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T50100 |
3-hydroxy-3-phenylpentanamide
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Others
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3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In p... |
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T69814 |
Neramexane Free Base
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Neramexane Free Base is a drug related to memantine, which acts as an NMDA antagonist and has neuroprotective effects. It is being developed for various possible applications, including treatment of tinnitus, Alzheimer's... |
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T83505 |
[DAla2] Dynorphin A (1-9) (porcine)
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[DAla2] Dynorphin A (1-9) (porcine) is a dynorphin utilized in research related to analgesic, addiction, and depression studies. |
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T16563 |
Pozanicline
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ABT-089 |
AChR
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Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine... |
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T11377 |
GDC-0276
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Others
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GDC-0276, a potent, selective, reversible, and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM, offers potential for pain treatment while overcoming limitations associated with current pain medications, inclu... |
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T38903 |
(S)-UFR2709
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(S)-UFR2709 |
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(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as wel... |
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T70433 |
Antalarmin
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Antalarmin is a CRF-1 antagonist. By blocking CRF-1 activity the release of ACTH is reduced, and chronic stress is decreased in response to chronic stress. Antalarmin could be useful in reducing the adverse health conseq... |
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T71177 |
LCRF-0004
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LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority o... |
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T79056 |
Orexin receptor modulator-1
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Orexin Receptor Modulator-1 is a compound utilized in the study of various conditions including substance addiction, panic disorder, anxiety, post-traumatic stress disorder (PTSD), pain, depression, seasonal affective di... |
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T81032 |
TAT-P4-(DATC5)2 TFA
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TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM and demonstrates potential in mitigating addiction behaviors in rat... |
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T81033 |
TAT-P4-(DATC5)2
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TAT-P4-(DATC5)2 is a potent peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibiting a high affinity with a dissociation constant (K_i) of 1.7 nM. This compound has demonstrat... |
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T76335 |
Dynorphin (2-17), amide (porcine)
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Dynorphin (2-17), amide (porcine) is a dynorphin derivative exhibiting analgesic properties. Belonging to the class of opioid peptides synthesized from the precursor protein dynorphinogen, dynorphin plays a pivotal role ... |
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T80482 |
α-Conotoxin EIIB
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Alpha-conotoxin EIIB |
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Alpha-Conotoxin EIIB is a peptide toxin derived from Conus ermineus that selectively binds to neuronal nicotinic acetylcholine receptors (nAChR) with a dissociation constant (Ki) of 2.2 nM. This compound is utilized in n... |
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T79804 |
5-HT2 agonist-1
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5-HT Receptor
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Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. The free base form of this compound is utilized in research pertaini... |
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T79637 |
CIAC001
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CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically acti... |
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T75917 |
CTAP TFA
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CTAP TFA, a potent and highly selective μ opioid receptor antagonist that effectively crosses the blood-brain barrier, exhibits a significant inhibition concentration (IC50) of 3.5 nM. It demonstrates extraordinary selec... |
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T79805 |
5-HT2 agonist-1 free base
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5-HT Receptor
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Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. It is utilized in research pertaining to depression... |
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T79806 |
5-HT2A&5-HT2C agonist-1
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5-HT Receptor
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5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM. It is applicable in the study of various central nervous system disor... |
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T62706 |
RTI-7470-44
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RTI-7470-44 is a potent and selective human trace amine-associated receptor 1 (hTAAR1) antagonist (IC50: 8.4 nM) that crosses the blood-brain barrier. RTI-7470-44 increases the spontaneous firing rate of dopaminergic neu... |
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T36995 |
MRT 68601 hydrochloride
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Potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.
Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1... |
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T37094 |
(S)-UFR2709 hydrochloride
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(S)-UFR2709 hydrochloride |
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(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol pre... |
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T83739 |
Myr-Tat-CBD3 TFA
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Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3 |
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Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound ... |
