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Search Results for " genomic "

ターゲット

18

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39

リコンビナントタンパク質

3

ライブラリー

カタログ番号 製品名 別名 ターゲット
T7318 Elimusertib BAY-1895344 ATM/ATR
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...
T3710 XMD16-5 Tyrosinase , PPAR
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is d...
T72024 ZIM
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chem...
T35363 HM-cytosine 5hmC,5-Hydroxymethylcytosine Others
HM-cytosine (5hmC) is a naturally occurring component of mammalian genomic DNA and is thought to be the sixth base of DNA [1]. HM-cytosine is an intermediate metabolite for demethylation of active DNA [2]. HM-cytosine is...
T3353 Niraparib hydrochloride MK-4827 hydrochloride,MK-4827 (hydrochloride) Apoptosis , Others , PARP
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...
T9497 Niraparib tosylate monohyrate PARP
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...
T11409 GLP-26 HBV
GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM...
T17031 TEI-9647 Others
TEI-9647 is a 1α,25-dihydroxy vitamin D3-26,23-lactone (1α,25-lactone) analog and is an effective VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist.
T28293 Pamiparib maleate BGB290,BGB 290,BGB-29 maleat 0
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc...
T70115 Pamiparib hydrate
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin...
T36593 TEI-9648
TEI-9648, an analogue of Vitamin D3 Lactone, acts as a potent and specific antagonist to the vitamin D receptor (VDR). This compound effectively blocks the genomic actions mediated by VDR and the Vitamin D responsive ele...
T62383 Anti-MRSA agent 2
Anti-MRSA agent 2 (compound 14) is a good inhibitor of methicillin-resistant Staphylococcus aureus (MRSA) (MIC: 0.098 μg/ml) with relatively low toxicity to normal cells. anti-MRSA agent 2 is a strong disruptor of bacter...
T63632 Anti-MRSA agent 3
Anti-MRSA agent 3 inhibits methicillin-resistant Staphylococcus aureus (MRSA) activity significantly (MIC: 0.098 μg/ml) with low toxicity to normal cells. anti-MRSA agent 3 has a high binding affinity for bacterial genom...
T63741 SGK1-IN-3
SGK1-IN-3 is a potent, orally active SGK1 inhibitor. Among them, the serine/threonine kinase SGK1, an activator of the β-linked protein pathway and a powerful stimulator of cartilage degradation, has been found to be upr...
T73500 AB-506
AB-506 is a compound that serves as an orally administered inhibitor specifically targeting the hepatitis B virus (HBV) core protein to obstruct HBV replication. It achieves this by binding to the HBV core protein, accel...
T35567 BIX01294 (hydrochloride hydrate)
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3)...
T82842 BODIPY FL EDA free base
ODIPY FL EDA free base, an amine-based green fluorescent probe, possesses an R-NH2 group able to undergo coupling with aldehydes or ketones, forming reversible Schiff base adducts. These intermediates can be subsequently...
T38309 LL-37 amide (trifluoroacetate salt)
LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPH-00759 FIV (isolate Petaluma) Gag polyprotein (His & Myc) FIV E. coli
Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane.; Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid co...
TMPH-00814 Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) HEV-3 P. pastoris (Yeast)
Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA. Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) is expressed in yeast with N-6xHis tag. The predicted molec...
TMPH-01674 Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc) HMPV E. coli
Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is ...
TMPH-00316 Bunyavirus La Crosse Nucleoprotein/NP Protein (His) Bunyavirus La Crosse P. pastoris (Yeast)
Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalizat...
TMPY-03786 PLAC9 Protein, Human, Recombinant (mFc) Human HEK293 Cells
PLAC9 belongs to the PLAC9 family. PLAC9 gene is a placental-enriched gene. There are other two placental-enriched genes: Plac1 and Plac8. Plac1 is strongly expressed in all trophoblast-derived cells in the placenta and ...
TMPY-04773 TPK1 Protein, Human, Recombinant (His) Human E. coli
Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism d...
TMPH-00523 DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) Escherichia phage RB69 E. coli
Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreadin...
TMPK-00153 BAMBI Protein, Human, Recombinant (hFc) Human HEK293 Cells
Bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) is a transmembrane protein that affects the growth, development and muscle regeneration of the body by regulating the TGF-β, BMP and Wnt signaling pat...
TMPH-01843 Human parainfluenza 4b virus (HPIV-4b) Nucleoprotein/NP Protein (His) HPIV-4b E. coli
Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replica...
TMPH-03416 Rift valley fever virus (RVFV) (strain ZH-548 M12) Nucleoprotein/NP Protein (His & SUMO) RVFV E. coli
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. After replication, the nucleocapsid is recr...
TMPH-01841 Human parainfluenza 1 virus (HPIV-1) Nucleoprotein/NP Protein (His) HPIV-1 E. coli
Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for trans...
TMPH-00811 Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) HDV P. pastoris (Yeast)
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II th...
TMPH-03062 Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) VP1 Protein (Flag & Myc) Norwalk virus HEK293 Cells
Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins ...
TMPH-03696 VSIV (strain San Juan) Nucleoprotein/NP Protein (His & Myc) VSIV E. coli
Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Nucleocapsid ass...
TMPH-00810 Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) HDV P. pastoris (Yeast)
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging ...
TMPY-04510 PSAP/Prosaposin Protein, Human, Recombinant (His) Human HEK293 Cells
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previ...
TMPY-00209 PSAP/Prosaposin Protein, Rat, Recombinant (His) Rat HEK293 Cells
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previ...
TMPH-00813 Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His) HEV-1 Baculovirus Insect Cells
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked...
TMPH-01237 POLQ Protein, Human, Recombinant (E. coli, His) Human E. coli
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-01238 POLQ Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPY-05028 NOTCH2NL Protein, Human, Recombinant (mFc) Human HEK293 Cells
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH fa...
TMPY-04137 ATP6V1F Protein, Human, Recombinant (GST) Human E. coli
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using revers...
TMPY-04268 NUDC Protein, Human, Recombinant (His) Human HEK293 Cells
NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic...
TMPH-00789 Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc) HaPyV E. coli
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on...
TMPY-04267 MSH2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPY-01586 ACPL2 Protein, Human, Recombinant (His) Human HEK293 Cells
acid phosphatase-like protein 2, also known as ACPL2, is a secreted protein which belongs to thehistidine acid phosphatase family. A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was und...
TMPY-01661 METTL1 Protein, Human, Recombinant (His) Human E. coli
tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. M...
TMPY-02955 CABP5 Protein, Human, Recombinant (His) Human E. coli
CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. ...
TMPH-02351 Influenza A H3N2 (strain A/Beijing/353/1989) Nucleoprotein/NP Protein (His & SUMO) H3N2 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02352 Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His) H3N2 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02355 Influenza A H3N2 (strain A/Port Chalmers/1/1973) Nucleoprotein/NP Protein (His & SUMO) H3N2 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPY-01308 AGO1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Protein argonaute-1, also known as eukaryotic translation initiation factor 2C 1, EIF2C1, and AGO1, is a member of the argonaute family and ago subfamily. Protein argonaute-1 in humans is encoded by the EIF2C1 gene. Th...
TMPH-02350 Influenza A H3N2 (strain A/Shanghai/16/1989) Nucleoprotein/NP Protein (His) H3N2 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02354 Influenza A H1N1 (strain A/New Jersey/8/1976) Nucleoprotein/NP Protein (His & SUMO) H1N1 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-02353 Influenza A H1N1 (strain A/Fort Warren/1/1950) Nucleoprotein/NP Protein (His & SUMO) H1N1 E. coli
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be l...
TMPH-01288 Elongin-B Protein, Human, Recombinant (GST) Human E. coli
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its...
TMPY-02150 GADD45A Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulatio...
TMPH-01270 TRAIP Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPH-01689 PLD6 Protein, Human, Recombinant (His) Human E. coli
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...
FIV (isolate Petaluma) Gag polyprotein (His & Myc)
TMPH-00759
Species: FIV
Expression System: E. coli
Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His)
TMPH-00814
Species: HEV-3
Expression System: P. pastoris (Yeast)
Human metapneumovirus (strain CAN97-83) Nucleoprotein/NP Protein (His & Myc)
TMPH-01674
Species: HMPV
Expression System: E. coli
Bunyavirus La Crosse Nucleoprotein/NP Protein (His)
TMPH-00316
Species: Bunyavirus La Crosse
Expression System: P. pastoris (Yeast)
PLAC9 Protein, Human, Recombinant (mFc)
TMPY-03786
Species: Human
Expression System: HEK293 Cells
TPK1 Protein, Human, Recombinant (His)
TMPY-04773
Species: Human
Expression System: E. coli
DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc)
TMPH-00523
Species: Escherichia phage RB69
Expression System: E. coli
BAMBI Protein, Human, Recombinant (hFc)
TMPK-00153
Species: Human
Expression System: HEK293 Cells
Human parainfluenza 4b virus (HPIV-4b) Nucleoprotein/NP Protein (His)
TMPH-01843
Species: HPIV-4b
Expression System: E. coli
Rift valley fever virus (RVFV) (strain ZH-548 M12) Nucleoprotein/NP Protein (His & SUMO)
TMPH-03416
Species: RVFV
Expression System: E. coli
Human parainfluenza 1 virus (HPIV-1) Nucleoprotein/NP Protein (His)
TMPH-01841
Species: HPIV-1
Expression System: E. coli
Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)
TMPH-00811
Species: HDV
Expression System: P. pastoris (Yeast)
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) VP1 Protein (Flag & Myc)
TMPH-03062
Species: Norwalk virus
Expression System: HEK293 Cells
VSIV (strain San Juan) Nucleoprotein/NP Protein (His & Myc)
TMPH-03696
Species: VSIV
Expression System: E. coli
Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc)
TMPH-00810
Species: HDV
Expression System: P. pastoris (Yeast)
PSAP/Prosaposin Protein, Human, Recombinant (His)
TMPY-04510
Species: Human
Expression System: HEK293 Cells
PSAP/Prosaposin Protein, Rat, Recombinant (His)
TMPY-00209
Species: Rat
Expression System: HEK293 Cells
Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)
TMPH-00813
Species: HEV-1
Expression System: Baculovirus Insect Cells
POLQ Protein, Human, Recombinant (E. coli, His)
TMPH-01237
Species: Human
Expression System: E. coli
POLQ Protein, Human, Recombinant (His)
TMPH-01238
Species: Human
Expression System: Baculovirus Insect Cells
NOTCH2NL Protein, Human, Recombinant (mFc)
TMPY-05028
Species: Human
Expression System: HEK293 Cells
ATP6V1F Protein, Human, Recombinant (GST)
TMPY-04137
Species: Human
Expression System: E. coli
NUDC Protein, Human, Recombinant (His)
TMPY-04268
Species: Human
Expression System: HEK293 Cells
Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)
TMPH-00789
Species: HaPyV
Expression System: E. coli
MSH2 Protein, Human, Recombinant (His & GST)
TMPY-04267
Species: Human
Expression System: Baculovirus Insect Cells
ACPL2 Protein, Human, Recombinant (His)
TMPY-01586
Species: Human
Expression System: HEK293 Cells
METTL1 Protein, Human, Recombinant (His)
TMPY-01661
Species: Human
Expression System: E. coli
CABP5 Protein, Human, Recombinant (His)
TMPY-02955
Species: Human
Expression System: E. coli
Influenza A H3N2 (strain A/Beijing/353/1989) Nucleoprotein/NP Protein (His & SUMO)
TMPH-02351
Species: H3N2
Expression System: E. coli
Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His)
TMPH-02352
Species: H3N2
Expression System: E. coli
Influenza A H3N2 (strain A/Port Chalmers/1/1973) Nucleoprotein/NP Protein (His & SUMO)
TMPH-02355
Species: H3N2
Expression System: E. coli
AGO1 Protein, Human, Recombinant (His)
TMPY-01308
Species: Human
Expression System: Baculovirus Insect Cells
Influenza A H3N2 (strain A/Shanghai/16/1989) Nucleoprotein/NP Protein (His)
TMPH-02350
Species: H3N2
Expression System: E. coli
Influenza A H1N1 (strain A/New Jersey/8/1976) Nucleoprotein/NP Protein (His & SUMO)
TMPH-02354
Species: H1N1
Expression System: E. coli
Influenza A H1N1 (strain A/Fort Warren/1/1950) Nucleoprotein/NP Protein (His & SUMO)
TMPH-02353
Species: H1N1
Expression System: E. coli
Elongin-B Protein, Human, Recombinant (GST)
TMPH-01288
Species: Human
Expression System: E. coli
GADD45A Protein, Human, Recombinant (His & GST)
TMPY-02150
Species: Human
Expression System: Baculovirus Insect Cells
TRAIP Protein, Human, Recombinant (His)
TMPH-01270
Species: Human
Expression System: E. coli
PLD6 Protein, Human, Recombinant (His)
TMPH-01689
Species: Human
Expression System: E. coli
カタログ番号 製品名
L3200 Autophagy Compound Library

1248 compounds
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L8200 Anti-Aging Compound Library

3279 compounds
A unique collection of 3279 anti-aging compounds for high throughput screening (HTS) and high content screening (HCS);
L9300 Macrocyclic Compound Library

210 compounds
210 macrocyclic compounds of known activity for high-throughput, high-content screening;