store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.
説明 | Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride. |
ターゲット&IC50 | ATR:7 nM (IC50) |
In vivo | The novel selective ATR kinase inhibitor BAY 1895344 on tumor cell growth and viability.?Potent antiproliferative activity was demonstrated in a broad spectrum of human tumor cell lines.?BAY 1895344 exhibited strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.?The combination of BAY 1895344 with DNA damage-inducing chemotherapy or external beam radiotherapy (EBRT) showed synergistic antitumor activity.?Combination treatment with BAY 1895344 and DDR inhibitors achieved strong synergistic antiproliferative activity in vitro, and combined inhibition of ATR and PARP signaling using olaparib demonstrated synergistic antitumor activity in vivo Furthermore, the combination of BAY 1895344 with the novel, nonsteroidal androgen receptor antagonist darolutamide resulted in significantly improved antitumor efficacy compared with respective single-agent treatments in hormone-dependent prostate cancer,?and addition of EBRT resulted in even further enhanced antitumor efficacy[1]. |
別名 | BAY-1895344 |
分子量 | 375.43 |
分子式 | C20H21N7O |
CAS No. | 1876467-74-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (29.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Elimusertib 1876467-74-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR response damage stress Inhibitor tumors DNA instability lymphomas inhibit solid BAY-1895344 ATM and RAD3 related Ataxia telangiectasia mutated replication genomic BAY1895344 repair BAY 1895344 inhibitor