|
T33412 |
MitoPQ
|
MitoParaquat |
Glucokinase
,
transporter
|
|
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of... |
|
T13867 |
RH01386
|
|
Others
|
|
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... |
|
T17177 |
TUG-424
|
TUG424 |
Others
|
|
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM). |
|
T12853 |
SBI-477
|
|
Others
|
|
SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal... |
|
TP2258 |
HNGF6A
|
|
Others
|
|
increases glucose stimulated insulin secretion and glucose metabolism |
|
T70113 |
ATM-1001
|
|
|
|
ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. |
|
T17094 |
Tifenazoxide
|
NN414 |
Others
|
|
Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo. |
|
TP2020 |
[Pro3]-GIP (Mouse)
|
|
|
|
GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra... |
|
T62836 |
Hit 1
|
|
|
|
Hit 1 is an activator of insulin-degrading enzymes (IDE) (EC50: 5.5 μM) and reduces glucose-stimulated insulin secretion. |
|
T71251 |
DS-1558
|
|
|
|
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp... |
|
TP2033 |
[Des-His1,Glu9]-Glucagon amide
|
des-His1-[Glu9]-Glucagon (1-29) amide |
|
|
Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr... |
|
T75833 |
HNGF6A TFA
|
|
|
|
HNGF6A TFA, a humanin analogue, enhances glucose-stimulated insulin secretion and glucose metabolism, offering potential for diabetes research. It also inhibits ROS (Reactive Oxygen Species) production under oxidative st... |
|
T76326 |
[Des-His1,Glu9] Glucagon
|
|
|
|
[Des-His1,Glu9] Glucagon, a powerful antagonist of the glucagon receptor system, plays a crucial role in enhancing the glucose-stimulated insulin release from pancreatic islet cells. This compound is utilized in diabetes... |
|
T80766 |
Xenin-8 TFA
|
|
|
|
Xenin-8 TFA, a C-terminal octapeptide derived from the 25-amino acid peptide Xenin belonging to the neurotensin/xenopsin family, is biologically active. It enhances basal insulin secretion and amplifies glucose-stimulate... |
|
T35604 |
Osteocalcin (1-49) (human) (trifluoroacetate salt)
|
|
|
|
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D ... |
|
T64553 |
GLP-1(7-37) TFA salt
|
|
|
|
The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine... |
|
T78066 |
BBT
|
|
Calcium Channel
|
|
BBT enhances glucose-stimulated insulin secretion (GSIS) in compromised conditions, demonstrates anti-hyperglycemia effects, and shields β-cells from cytokine- or streptozotocin (STZ)-triggered apoptosis in type 2 diabet... |
|
T35854 |
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
|
|
|
|
9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a r... |
|
T37579 |
GW 1929 hydrochloride
|
|
|
|
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr... |
|
T83694 |
Gastric Inhibitory Peptide (1-42) (porcine) TFA
|
GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42) |
|
|
Gastric inhibitory peptide (GIP) (1-42), an endogenous incretin hormone comprising 42 amino acids, promotes insulin secretion. Expressed in the intestinal neuroendocrine K cells and submandibular gland, it enters circula... |
|
T35598 |
Neuromedin U-25 (human) (trifluoroacetate salt)
|
|
|
|
Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-med... |
|
T35814 |
Urocortin III (human) (trifluoroacetate salt)
|
|
|
|
Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin II... |
