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T0383 |
Fenspiride hydrochloride
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Fenspiride HCl,Pneumorel,Fluiden,Decaspiride |
Adrenergic Receptor
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PDE
,
Histamine Receptor
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Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory ... |
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T16965 |
Symetine
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L 16726 |
Parasite
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Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs. |
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T13331 |
WAY127093B racemate
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PDE
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WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs. |
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T31195 |
Dalcotidine
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KU 1257,KU-1257 |
Histamine Receptor
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Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value f... |
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T23283 |
2-Methoxyidazoxan monohydrochloride
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RX 821002 hydrochloride |
Adrenergic Receptor
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L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ... |
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T4535L |
Etomoxir
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(R)-(+)-Etomoxir |
Antioxidant
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CPT
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Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory eff... |
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TP1358L |
Peptide M acetate
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Peptide M acetate(110652-62-5 free base) |
Others
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T68109 |
Moxipraquine
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Antibiotic
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Moxipraquine is a novel 8-aminoquinolone compound with anti-infective activity against Trypanosoma cruzi. Moxipraquine effectively inhibited parasitemia but did not eradicate infections in mice or guinea pigs. Moxipraqui... |
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T33647L |
Nesosteine Lithium
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Nesosteine Lithium(84233-61-4 Free baes) |
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Nesosteine Lithium is a novel mucoregulatory that inhibits Herxheimer microconvulsions in guinea pigs and inhibits ovalbumin-induced histamine release from sensitized trachea.Nesosteine Lithium protects against ovalbumin... |
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T15647 |
Tipelukast
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MN 001,KCA 757 |
Leukotriene Receptor
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Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma. |
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T30110 |
AR 12456
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AR12456,AR-12456 |
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AR-12456 is a Trapidil derivative that prevents serum hyperlipidemia in guinea pigs. |
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T23829 |
Btm 1042
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Btm1042,Btm-1042 |
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Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs. |
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T32770 |
Linsidomine
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CV 664 |
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Lincydomine is a smooth muscle relaxant, beneficial to the treatment of unstable angina pectoris, but also can open the respiratory tract of humans and guinea pigs. |
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T27915 |
LY 302148
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LY-302148,LY302148 |
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LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics. |
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T82424 |
Experimental allergic encephalitogenic peptide (human)
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Experimental allergic encephalitogenic peptide (human), an EAE peptide, induces encephalomyelitis in guinea pigs [1]. |
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T38266 |
Nirogacestat dihydrobromide
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Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Lanz et al (2010) Pharmacodynamics and pharmaco... |
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T70106 |
F-050
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F-050 is a biochemical that has been shown to inhibit platelet aggregation induced by CaCl2, arachidonic acid, collagen, adenosine diphosphate (ADP) and thrombin in guinea pigs, rabbits and rats in vitro. F-050 may be us... |
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T36772 |
11-deoxy Prostaglandin F1β
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11-deoxy Prostaglandin F1β |
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11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μg/kg. |
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T28296 |
Parogrelil hydrochloride
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INDI-702,NM-702,NT-702,NM702,INDI702 |
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Parogrelil is a phosphodiesterase (PDE3/PDE5A) inhibitor potentially for the treatment of intermittent. Parogrelil suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. ... |
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T67962 |
Sulukast
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Sulukast is a potent inhaled leukotriene antagonist, which was found to be effective in preventing both leukotriene_x0002_and antigen-induced bronchospasm in guinea-pigs. |
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T36621 |
Prostaglandin F2β
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Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and... |
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T68242 |
D-Mabuterol hydrochloride
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D-Mabuterol hydrochloride is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guin... |
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T36771 |
11-deoxy Prostaglandin F1α
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11-deoxy Prostaglandin F1α |
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11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that ... |
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T69085 |
Mabuterol, (S)-
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Mabuterol, (S)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. M... |
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T69084 |
Mabuterol, (R)-
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Mabuterol, (R)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. M... |
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T60419 |
Cyclic HPMPC
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Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcom... |
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T36770 |
11-deoxy Prostaglandin E1
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11-deoxy Prostaglandin E1 |
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11-deoxy Prostaglandin E1 is a prostaglandin E1 analogue that has bronchodilator activity and can inhibit histamine-induced bronchoconstriction and cause relaxation of tracheal strips in isolated guinea pigs. |
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T83924 |
(R)-(+)-Deoxyarbutin
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(R)-(+)-Deoxyarbutin, an isomer of deoxyarbutin, acts as a tyrosinase inhibitor. Effective at a concentration of 21 µM, it diminishes tyrosinase activity and has been demonstrated to lighten the skin in hairless guinea p... |
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T70376 |
CHF-6366
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CHF-6366 is a dual-action chemical compound acting as a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist, with respective pK i values of 10.4 and 11.4. Additionally, it exhibits weak calcium channel in... |
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T69215 |
Ambrein
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Ambrein is a triterpene alcohol that is the chief constituent of ambergris, a secretion from the digestive system of the sperm whale, and has been suggested as the possible active component producing the supposed aphrodi... |
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T37728 |
Methoctramine (hydrate)
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Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, re... |
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T36618 |
Rupatadine
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Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ... |
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T13460 |
(+)-Cevimeline hydrochloride hemihydrate
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(+)-AF102B hydrochloride hemihydrate,(+)-SNI-2011 |
Others
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(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, stands as a promising therapeutic candidate for treating xerostomia in Sjogren's syndrome. This compound has demonstrated a b... |
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T13421 |
(-)-Cevimeline hydrochloride hemihydrate
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(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate |
ALK
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Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's syndrome, exhibiting an IC50 value indicative of its affini... |
