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Search Results for " mucin "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
TP1309	Gastric mucin		Antibacterial , Antibiotic
	Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.		Antibacterial , Antibiotic
T38976	MUC1, mucin core	MUC1, mucin core
	MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.
T11668	IQB-782		Others
	IQB-782 is a mucolytic agent with mucolytic expectorant activity.IQB-782 inhibits thrombin-activating fibrinolytic inhibitor (TAFI), protects rats from tobacco smoke-induced respiratory obstruction, reduces the viscosity...		Others
T1481	Fudosteine		Others
	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.		Others
T12282	Benzyl-α-GalNAc	O-glycosylation-IN-1	Others
	Benzyl-α-GalNAc (O-glycosylation-IN-1) is a potent inhibitor of O-glycosylation and is used to reduce mucin on cell surfaces.		Others
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T62125	Colistin adjuvant-1
	Colistin adjuvant-1 is a mucin adjuvant with enhanced mucin-enhancing activity against gram-negative bacteria. colistin adjuvant-1 exhibits inhibition of NF-κB (IC50: 0.209 μM).
TP1834	MUC5AC motif peptide
	MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
T76967	Ubamatamab
	Ubamatamab (REGN4018), a human bispecific antibody targeting Mucin 16 (MUC16) and CD3, exhibits potent antitumor activity [1].
T78318	Gatipotuzumab	PankoMab
	Gatipotuzumab (PankoMab), a humanized monoclonal antibody, targets the tumor-specific epitope TA-MUC1 of mucin-1 and exhibits potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) [1] [2].
T78334	Surzebiclimab	BGB-A425
	Surzebiclimab (BGB-A425), a humanized variant IgG1 monoclonal antibody, targets and binds with high affinity (K D = 0.36 nM) and specificity to the extracellular domain of T-cell immunoglobulin and mucin-domain containin...
T80919	Tumour-associated MUC1 epitope
	Tumor-associated MUC1 epitope, a biologically active peptide, is the distinctive feature of MUC1 mucin—a significantly glycosylated type I transmembrane glycoprotein. Its extracellular domain comprises variable numbers o...
T35578	Phosphatidylserines (sodium salt)	Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...

Compounds

Gastric mucin

TP1309

Synonym:

Target: Antibacterial, Antibiotic

MUC1, mucin core

T38976

Synonym: MUC1, mucin core

Synonym: O-glycosylation-IN-1

Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger

Tumour-associated MUC1 epitope

T80919

Synonym:

Target:

Phosphatidylserines (sodium salt)

T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Target:

カタログ番号	製品名	別名	ターゲット
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T3821	Deapioplatycodin D	Deapi-platycodin D,DesapioplatycodinD	Others , HCV Protease
	Deapioplatycodin D and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonar...		Others , HCV Protease
TN2089	Platycodin D3		HCV Protease , NF-κB
	Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced...		HCV Protease , NF-κB
T2S2108	Coixol	6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA	Others , Antibacterial
	1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate fo...		Others , Antibacterial
TN1848	Kuwanon E		AChR
	Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme...		AChR
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...

天然物製品

Obtusifolin

T4S0969

Synonym:

Target: Antioxidant, NF-κB

Prunetin

T4S0878

Synonym: Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Deapioplatycodin D

T3821

Synonym: Deapi-platycodin D,DesapioplatycodinD

Target: Others, HCV Protease

Platycodin D3

TN2089

Synonym:

Target: HCV Protease, NF-κB

Coixol

T2S2108

Synonym: 6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA

Target: Others, Antibacterial

Target: Prostaglandin Receptor, AMPK

Phosphatidylserines (bovine)

T35577

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04340	Mucin-1/MUC1 Protein, Human, Recombinant	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.4 kDa and the accession number is P15941-11.
TMPY-02005	Mucin-1/MUC1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42 kDa and the accession number is P15941-11.
TMPJ-00565	Mucin-15/MUC15 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Mucin-15 is a single-pass type I membrane protein member of the Mucin family. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans...
TMPJ-01456	Mucin-17/MUC17 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was m...
TMPJ-00155	Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated	Human	HEK293 Cells
	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also ...
TMPY-02871	Mucin-1/MUC1 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41 kDa and the accession number is P15941-11.
TMPY-06833	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.28 kDa and the accession number is P15941-1.
TMPY-06832	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.19 kDa and the accession number is P15941-1.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire...
TMPY-05581	TIM-4/TIMD4 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	TIM-4/TIMD4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is AAH08988.1.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPY-01072	CCL5 Protein, Human, Recombinant (His & mucin)	Human	HEK293 Cells
	CCL5 Protein, Human, Recombinant (His & mucin) is expressed in HEK293 mammalian cells with His and mucin tag. The predicted molecular weight is 34 kDa and the accession number is D0EI67.
TMPY-00573	MUCL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MUCL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 8.4 kDa and the accession number is Q96DR8.
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPH-01706	Mucin-16/MUC16 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. ...
TMPH-01708	Mucin-2/MUC2 Protein, Human, Recombinant (His)	Human	E. coli
	Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constitu...
TMPH-01709	Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Mucin-5B/MUC5B Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression...
TMPJ-01432	CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293 Cells
	MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by t...
TMPJ-00189	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, an...
TMPY-02124	TIM-4/TIMD4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TIM-4/TIMD4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.7 kDa and the accession number is AAH08988.1.
TMPJ-00624	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)	Marmoset	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is F7I881.
TMPY-00133	PARM-1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PARM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is AAH13294.1.
TMPY-01375	TIM-4/TIMD4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TIM-4/TIMD4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.3 kDa and the accession number is Q6U7R4.
TMPJ-00174	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.
TMPJ-00173	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)	Mouse	HEK293 Cells
	TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is Q8VIM0.
TMPY-00199	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP1 (mucin domain deleted) Protein (aa 1-320, His)	EBOV	Baculovirus Insect Cells
	Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein/GP1 (mucin domain deleted) Protein (aa 1-320, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 33.8 kDa and the acce...
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family o...
TMPH-00044	RuvC Protein, Akkermansia muciniphila, Recombinant (His & Myc)	Akkermansia muciniphila	E. coli
	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junct...
TMPY-03262	B3GNT6 Protein, Human, Recombinant (aa 44-384, His)	Human	Baculovirus Insect Cells
	B3GNT6 belongs to the glycosyltransferase 31 family. B3GNT6 play s an important role in the synthesis of mucin-type O-glycans in digestive organs. It catalyzes the transfer of GlcNAc from UDP-GlcNAc to GalNAcalpha1-Ser/T...
TMPK-01272	TIM-4/TIMD4 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Tim4 is a transmembrane protein as the phosphatidylserine (PS) receptor, known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed highly in macrophages, and macrophage Tim-4 inhibits inflamma...
TMPK-01141	TIM-4/TIMD4 Protein, Human, Recombinant (aa 25-314, His)	Human	HEK293 Cells
	Tim4 is a transmembrane protein as the phosphatidylserine (PS) receptor, known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed highly in macrophages, and macrophage Tim-4 inhibits inflamma...
TMPK-00286	Siglec-9 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expr...
TMPK-00287	Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expr...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPJ-00673	CX3CL1/Fractalkine Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytop...
TMPJ-01173	TFF3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process calle...
TMPJ-00045	Podoplanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weak...
TMPY-03353	CEL Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activ...
TMPJ-01089	TFF1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing...
TMPH-00672	Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)	E. coli	E. coli
	Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves h...