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T0871 |
Noradrenaline bitartrate
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|
Adrenergic Receptor
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Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... |
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T19654 |
Guanoclor
|
VATENSOL |
Others
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|
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. |
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T23070 |
Nisoxetine hydrochloride
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|
Sodium Channel
,
Monoamine Transporter
,
Norepinephrine
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|
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor |
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T0166 |
Pancuronium dibromide
|
Pancuronium bromide,Pavulon |
AChR
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|
Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ... |
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T7341 |
Diclofensine
|
Ro 8-4650 |
Dopamine Receptor
,
Monoamine Transporter
|
|
Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine. |
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T37015 |
Iprindole
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5-HT Receptor
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Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. |
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T0472 |
Venlafaxine hydrochloride
|
Venlafaxine HCl,Wy 45030 hydrochloride |
5-HT Receptor
,
Serotonin Transporter
|
|
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. |
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T5327 |
Amezinium methylsulfate
|
Amezinium metilsulfate,Amezinium (methylsulfate),Lu-1631 |
Adrenergic Receptor
|
|
Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake. |
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T1471 |
Duloxetine hydrochloride
|
Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i... |
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T16816 |
S 18986
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GluR
|
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S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine... |
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T1580 |
Desvenlafaxine
|
WY 45233 Succinate,O-Desmethylvenlafaxine |
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive age... |
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TP2106L |
Urantide acetate(669089-53-6 free base)
|
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Neurotensin Receptor
|
|
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ... |
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T28951 |
Tesofensine
|
NS 2330,NS2330,NS-2330 |
|
|
Tesofensine, a serotonin–noradrenaline–dopamine reuptake inhibitor, is used potentially for the treatment of obesity. |
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T36949 |
Niaprazine
|
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5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
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T69335 |
Ciclazindol hydrochloride
|
|
|
|
Ciclazindol hydrochloride is the salt from of Ciclazindol (free base), a noradrenaline uptake inhibitor. |
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T69568 |
FLA-63
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|
|
|
FLA-63 is a dopamine-beta-hydroxylase (DBH)-inhibitor and an inhibitor of the last step of noradrenaline biosynthesis. |
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T69389 |
Desethylreboxetine
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|
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Desethylreboxetine is an desethylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. |
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T69331 |
Ciclazindol (free base)
|
|
|
|
Ciclazindol (free base) is a noradrenaline uptake inhibitor. |
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T26970 |
CD-349
|
CD 349,CD349 |
|
|
CD-349 is a calcium channel antagonist. CD-349 inhibits the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium. |
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T69509 |
SCH-12650 maleate
|
|
|
|
SCH-12650 maleate is a noradrenaline uptake and gastric secretion inhibitor. |
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T33006 |
LY-104119
|
LY 104119,LY104119 |
|
|
LY-104119 is a thermogenic weight loss compound that rapidly reduces noradrenaline concentrations in brown adipose tissue between the scapulas, the heart, and the liver. |
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T10145 |
4-Hydroxyatomoxetine
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Others
|
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4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor. |
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T60368 |
Benzoctamine
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|
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Benzoctamine is an orally active and potent psychoactive agent with tranquillizing properties. Benzoctamine increases the turnover rate of catecholamines. Benzoctamine enhances the uptake of [3H]noradrenaline in the rat ... |
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T69270 |
Amezinium
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|
|
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Amezinium is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake. |
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T68327 |
Dexnafenodone Free Base
|
|
|
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Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressant... |
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T11892 |
Lurasidone D8 Hydrochloride
|
SM-13496 D8 |
Others
|
|
Lurasidone D8 Hydrochloride is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C, and is the deuterium labeled Lurasidone. |
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T29002 |
Trazium Esilate
|
EGYT3615,EGYT-3615,EGYT 3615 |
|
|
Trazium esilate is an adrenergic receptor antagonist. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat... |
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T10144 |
4-Hydroxyatomoxetine D3
|
|
Others
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4-Hydroxyatomoxetine D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inh... |
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T69071 |
Secoverine
|
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|
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Secoverine is a selective muscarinic receptor antagonist that was studied as a neurotropic spasmolytic agent. It was shown that the drug had no nicotinolytic or antihistaminic activity, a moderate antisterotonic activity... |
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T31582 |
DSP 4
|
DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4 |
|
|
DSP 4 is a selective neurotoxin selective for noradrenergic neurons in the locus coeruleus noradrenergic system and capable of crossing the blood–brain barrier and cyclizes to a reactive aziridinium derivative that is ac... |
|
T1735 |
Lurasidone hydrochloride
|
Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antag... |
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T37699 |
Org 24598
|
|
|
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Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transport... |
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T69145 |
Nisoxetine
|
|
|
|
Nisoxetine, a potent and selective noradrenaline transporter (NET) inhibitor with a dissociation constant (Kd) of 0.76 nM, serves as an antidepressant and exhibits local anesthetic properties by blocking voltage-gated so... |
|
TP2106 |
Urantide
|
|
|
|
Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acet... |
|
T74045 |
H-Lys-Tyr-OH TFA
|
|
|
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Lysyltyrosine TFA (H-Lys-Tyr-OH TFA) is a dipeptide consisting of lysine and tyrosine. It enhances brain function or mitigates neurological diseases by facilitating the release of noradrenaline and tyrosine into the brai... |
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T69133 |
Etozolin HCl
|
|
|
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Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vasc... |
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T71356 |
Lanperisone HCl
|
|
|
|
Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK43... |
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T73083 |
Nipradolol
|
KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351 |
|
|
Nipradolol (KT-210; K-351), an alpha-1-adrenergic receptor antagonist, effectively inhibits the elevation of intraocular pressure (IOP) induced by Phenylephrine in an albino rabbit model and suppresses noradrenaline (NA)... |
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T72701 |
Cavα2δ1&NET-IN-3
|
|
|
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Cavα2δ1&NET-IN-3 (example 216) is an inhibitor targeting both the α2δ subunit of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET). It exhibits inhibitory constants (Ki) ranging from 100 to 50... |
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T71772 |
Bicifadine free base
|
|
|
|
Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less ... |
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TMIH-0001 |
(+/-)-Venlafaxine-d6 HCl
|
|
|
|
(+/-)-Venlafaxine-d6 HCl is a deuterated compound of (+/-)-Venlafaxine HCl. (+/-)-Venlafaxine HCl has a CAS number of 99300-78-4. Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions... |
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T28653 |
S-8510 free base
|
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
|
|
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ame... |
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T72209 |
(R,R)-Reboxetine mesylate
|
(R,R)-FCE20124 mesylate ; (R,R)-PNU155950E mesylate,(R,R)-PNU155950E mesylate,(R,R)-FCE20124 mesylate |
|
|
(R,R)-Reboxetine mesylate, an antidepressant agent, exhibits high bioavailability and is the (R,R) enantiomer of Reboxetine, a selective noradrenaline reuptake inhibitor. Contrasting its counterpart, the (S,S) enantiomer... |
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TMIH-0205 |
Duloxetine-d3 HCl
|
|
|
|
Duloxetine-d3 HCl is a deuterated compound of Duloxetine HCl. Duloxetine HCl has a CAS number of 136434-34-9. Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTON... |
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T2306 |
Brexpiprazole
|
OPC-34712 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
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T68190 |
Carmoxirole (free base)
|
|
|
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Carmoxirole (free base) is a dopamine D2 receptor agonist with limited central activity that modulates sympathetic activation and subsequently reduces pre-load and afterload in animals. It was shown, that carmoxirole ind... |
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T74582 |
Trimipramine N-oxide
|
|
|
|
Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organ... |
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T78126 |
Dothiepin
|
Dosulepin,Dothep |
Histamine Receptor
|
|
Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. ... |
