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T9193 |
ACH-000143
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|
Melatonin Receptor
,
MT Receptor
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|
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
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T21902 |
ML351
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|
Lipoxygenase
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ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). |
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T8676 |
FOY 251
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|
Others
,
Serine/threonin kinase
,
SARS-CoV
|
|
FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate. |
|
T0839 |
Ketoprofen
|
RP-19583 |
Apoptosis
,
COX
,
MRP
|
|
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... |
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T26986 |
Cevoglitazar
|
LBM-642,LBM 642,LBM642 |
PPAR
|
|
Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys. |
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T24121 |
GW438014A
|
GW 438014 A,GW-438014-A |
Neuropeptide Y Receptor
|
|
GW438014A is a potent, selective antagonist of the NPY-Y5 receptor, effectively inhibiting food consumption and curbing body weight gain in obese rodents. |
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T15679 |
L 152804
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Neuropeptide Y Receptor
|
|
L 152804 is a specific antagonist of the neuropeptide Y Y5 receptor and modulates food intake and energy expenditure thus causing weight loss in diet-induced obese mice. |
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TP2047L |
CRF (6-33) acetate(120066-38-8 free base)
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CRFR
|
|
CRF (6-33) acetate is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo. |
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TP1913L1 |
BA 1 acetate(183241-31-8 free base)
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Bombesin Receptor
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BA 1 acetate is a potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 ... |
|
T4681 |
T863
|
DGAT-3,DGAT-1 inhibitor |
Acyltransferase
,
Transferase
|
|
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... |
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T38074 |
Thiodigalactoside
|
|
Galectin
|
|
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflamma... |
|
T3685 |
SR9009
|
Stenabolic,REV-ERB Agonist II |
Autophagy
|
|
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during... |
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TP1930L1 |
Spexin acetate(1370290-58-6 free base)
|
|
Neuropeptide Y Receptor
|
|
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits... |
|
TP1679 |
BDC2.5 mimotope 1040-51
|
|
|
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BDC2.5 mimotope 1040-51 is a mimotope peptide for diabetogenic T cell clone BDC2.5. isolated from non-obese diabetic mice.This is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. from non-... |
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T10613 |
BRL 37344 sodium
|
BRL 37344A |
Others
|
|
BRL 37344 sodium is a specific agonist of the β3-adrenergic receptor. The treatment of BRL 37344 sodium significantly lowers the bodyweight of obese mice. |
|
TP2047 |
CRF(6-33)(human)
|
CRF (6-33) |
|
|
CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo. |
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TP1913 |
BA 1
|
|
|
|
Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell p... |
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T35265 |
YM-440
|
YM440,YM 440 |
|
|
YM-440 is a novel hypoglycemic agent, an insulin sensitizer, that may be used for the treatment of type 2 diabetes mellitus by reducing glucose 6-phosphatase activity in obese Zucker rats and inhibiting liver glucose out... |
|
T81663 |
NN1177
|
NNC9204-1177 |
|
|
NN1177, a long-acting GLP-1/glucagon receptor co-agonist, exhibits a dose-dependent reduction in body weight among diet-induced obese (DIO) mice and has potential applications in the study of weight loss and metabolic re... |
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T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
|
|
|
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlate... |
|
T28511 |
Reglitazar
|
JTT-501,JTT501,PNU-182716,PNU182716,PNU-716 |
|
|
Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non... |
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T21811 |
LH 21
|
|
|
|
LH-21 is a potent in vivo neutral cannabinoid CB1 receptor antagonist. LH-21 reduces food intake and body weight gain in obese Zucker rats., and results in a dose-dependent inhibition of feeding [1]. |
|
T37640 |
Trans-2-Hexadecenoyl-L-carnitine
|
|
|
|
trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine[1].
[1]. Pengxiang She, et al. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013;8(3):e59443. |
|
T35631 |
Peptide YY (human) (trifluoroacetate salt)
|
Peptide Tyrosine Tyrosine |
|
|
Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-in... |
|
T76002 |
Spexin TFA
|
|
|
|
Spexin TFA, a potent agonist for galanin receptor 2/3 (GAL2/GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galanin receptor 1. As an endogenous peptide promoting satiety, ... |
|
T81214 |
SAR441255
|
|
|
|
SAR441255 is a potent unimolecular peptide that acts as a GLP-1/GIP/GCG receptor triagonist, demonstrating balanced activation across all three target receptors. It has shown positive acute glucoregulatory effects in dia... |
|
T15043 |
D5D-IN-326
|
|
Others
|
|
|
|
T82079 |
IGRP(206-214)
|
|
|
|
IGRP(206-214) is an bioactive peptide corresponding to residues 206–214 of the murine islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP). It induces diabetes in non-obese diabetic (NOD) mice by... |
|
T35445 |
1-Stearoyl-3-Oleoyl-rac-glycerol
|
|
|
|
1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-... |
|
TP1930 |
Spexin
|
|
|
|
Potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty ac... |
|
T35622 |
FKGK 18
|
|
|
|
FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA... |
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T82354 |
GAD65 (524-543)
|
|
|
|
GAD65 (524-543) is a biologically active peptide comprising amino acids 524 to 543 of glutamic acid decarboxylase 65 (GAD65). It represents an early islet antigen fragment that elicits proliferative T cell responses in t... |
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T35813 |
CAY10592
|
|
|
|
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |
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T35547 |
YW1128
|
|
|
|
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein ... |
|
T35799 |
MBX-8025 (sodium salt)
|
|
|
|
MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa... |
