|
T5447 |
Anle138b
|
|
Beta Amyloid
,
Others
|
|
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease |
|
T22012 |
7BIO
|
|
FLT
,
DYRK
,
Aurora Kinase
|
|
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases. |
|
T6909 |
NSC348884
|
|
Apoptosis
,
p53
|
|
NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines. |
|
T10789 |
Chitosan oligosaccharide
|
COS |
AMPK
|
|
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK. |
|
T14199 |
ALZ-801
|
Valiltramiprosate |
Beta Amyloid
|
|
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-m... |
|
T12532 |
PQM130
|
|
Beta Amyloid
|
|
|
|
T38860 |
Golodirsen
|
Golodirsen,SRP-4053 |
|
|
Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) designed to selectively bind and target exon 53 of dystrophin pre-mRNA, with applications in the investigation of Duchenne muscular dystrophy (DMD). |
|
T34418 |
RS-0406
|
RS0406,Phenol |
|
|
RS-0406 is a new type of β-flakes blocker, which can reverse amyloid β-induced cytotoxicity and long-term enhanced damage in vitro, and inhibit amyloid-oligomer-induced behavior deterioration in vivo. |
|
T24779 |
SEN-1269
|
|
|
|
SEN-1269 is an amyloid-β (AB) aggregation inhibitor that acts by blocking Aβ(1-42) aggregation and protecting neuronal cell lines exposed to Aβ(1-42), reducing Aβ oligomer-induced LTP and memory deficits in vivo. |
|
T21097 |
Decamethyltetrasiloxane
|
Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780 |
|
|
Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to ot... |
|
T81912 |
LSP-GR3
|
|
iGluR
|
|
LSP-GR3, a novel splice modulating oligomer (SMO) consisting of chemically-modified RNA oligonucleotides, potently and specifically directs the alternative splicing of GluR to promote GluR3-flip expression across the cen... |
|
T76395 |
(Met(O)35)-Amyloid β-Protein (1-42)
|
|
|
|
(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of Aβ40. This compound is utilized in Alzheimer’s disease (AD) re... |
|
T38859 |
Casimersen
|
SRP-4045 |
|
|
Casimersen (SRP-4045) is an antisense oligonucleotide, specifically belonging to the phosphorodiamidate morpholino oligomer subclass. It binds to exon 45 of dystrophin pre-mRNA, effectively restoring the open-reading fra... |
|
T83173 |
Activated T Subunit
|
|
|
|
Activated T Subunit is employed in synthesizing exon-jumping oligomer conjugates that target specific sites within the human anti-muscular atrophy protein gene to induce exon 51 skipping, a potential avenue for muscular ... |
|
T83175 |
Activated DPG Subunit
|
|
|
|
Activated DPG subunit facilitates the synthesis of exon jumping oligomer conjugates targeting specific sites within the human anti-muscular atrophy protein gene to induce exon 51 skipping, a potential research avenue for... |
|
T83176 |
Activated C Subunit
|
|
|
|
Activated C Subunit is utilized in synthesizing exon jumping oligomer conjugates that complement specific target sites within the human anti-muscular atrophy protein gene to promote exon 51 skipping, offering a research ... |
|
T81693 |
NCP2 Anchor
|
|
|
|
NCP2 Anchor is employed in synthesizing exon jumping oligomer conjugates that align with specific target sequences within the human anti-muscular atrophy protein gene to promote exon 52 skipping, facilitating research in... |
|
T83177 |
Activated A Subunit
|
|
|
|
Activated A Subunit is instrumental in synthesizing exon skipping oligomer conjugates, which are designed to specifically pair with chosen sequences within the human anti-muscular atrophy protein gene, thereby promoting ... |
|
T83174 |
Activated EG3 Tail
|
|
|
|
Activated EG3 Tail facilitates the synthesis of exon-skipping oligomer conjugates that target specific sites within the human anti-muscular atrophy protein gene, promoting exon 51 skipping. This compound holds potential ... |
|
T71855 |
Z640
|
|
|
|
Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from am... |
