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T27242 |
EF24
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EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone |
ERK
,
MEK
,
Caspase
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EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ... |
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T71479 |
Kahweol oleate
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Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell ... |
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T35821 |
CAY10721
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CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph no... |
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T68642 |
Kahweol palmitate
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Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducin... |
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T71478 |
Kahweol stearate
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Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... |
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T68641 |
Kahweol Acetate
|
|
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Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing ... |
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T71480 |
Kahweol linoleate
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|
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Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... |
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T16354 |
NSC745885
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Others
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NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cel... |
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T73662 |
Peplomycin
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Peplomycin (Bleomycin PEP; Pepleomycin), an analogue of Bleomycin, exhibits significant antitumor activity with reduced pulmonary toxicity. It induces apoptosis in the oral squamous carcinoma cell line SSCKN and causes p... |
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T79602 |
MTP
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|
Autophagy
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MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation. Further, it inhibits JAK2 signaling, rendering it useful for the study of ora... |
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T36844 |
Inostamycin A
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Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)... |
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T35426 |
β-Defensin-1 (human) (trifluoroacetate salt)
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|
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β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus... |
