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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T1457	Deferasirox	ICL 670,CGP-72670	Others , Ferroptosis , Antibacterial
	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.		Others , Ferroptosis , Antibacterial
T19692	Deferitrin	GT 56252,GT 56 252,GT-56252,GT-56-252	Others
	Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.		Others
T32046	HBED	CHELII,CHEL II,CHEL-II	Others
	HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.		Others
T10874	CP-060		Calcium Channel
	CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities.		Calcium Channel
T13639	Deferasirox (Fe3+ chelate)		Apoptosis
	Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.		Apoptosis
T8891	Homo-VK-II-36	Homo-V-II-36	Others
	Homo-VK-II-36 (Homo-V-II-36) is a carvedilol analogue that acts by inhibiting store- overload-induced calcium release through the RyR2 channel.		Others
T68284	NP-04634		Others
	NP-04634 is a calcium antagonist and protective agent against calcium overload and mitochondrial disruption.		Others
T40694	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid		Others
	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid exhibits hypoglycemic activity and operates through a mechanism dependent on the response to oral glucose overload.		Others
T31363	Deferitazole magnesium	FBS0701,FBS-0701,SSP-004184,SHP-602,SHP602,Deferitazole free base	Others
	Deferitazole magnesium is a potential chelator for iron overload treatment.		Others
T64249	CYP11B1-IN-2		Others
	CYP11B1-IN-2 (compound 7aa) is a selective, orally active inhibitor of CYP11B1 that acts on human CYP11B1 (IC50: 9 nM) and rat CYP11B1 (IC50: 25 nM). CYP11B1-IN-2 can be used to study diseases caused by cortisol overload...		Others
T85022	CN128	R-CN128	Others
	CN128, an orally bioavailable iron chelator, features a side chain hydroxy group serving as an alternate sacrificial glucuronidation site to mitigate metabolic inactivation at the 3-hydroxy group. When administered at do...		Others
T84718	Folic acid disodium	Vitamin B9 disodium,Vitamin M disodium	Others
	Folic acid disodium, an orally active disodium salt form of Folic acid, showcases an intrinsic dissolution rate (IDR) of 4.96·10^5 g/s [1]. It acts as a cofactor in single-carbon transfer reactions and has protective rol...		Others

Compounds

Deferasirox

T1457

Synonym: ICL 670,CGP-72670

Target: Others, Ferroptosis, Antibacterial

Deferitrin

T19692

Synonym: GT 56252,GT 56 252,GT-56252,GT-56-252

Target: Others

HBED

T32046

Synonym: CHELII,CHEL II,CHEL-II

Target: Calcium Channel

Deferasirox (Fe3+ chelate)

Synonym: Homo-V-II-36

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

T40694

Synonym:

Target: Others

Deferitazole magnesium

T31363

Synonym: FBS0701,FBS-0701,SSP-004184,SHP-602,SHP602,Deferitazole free base

Synonym: Vitamin B9 disodium,Vitamin M disodium

Target: Others

カタログ番号	製品名	別名	ターゲット
T20819	Ammonium iron(III) citrate	Ferric ammonium citrate	Others , Ferroptosis
	Ammonium iron(III) citrate (Ferric ammonium citrate) is a physiological form of non-ferritin-bound iron that causes intracellular iron overload leading to cellular iron death and enhances protein production.		Others , Ferroptosis
TWP2911	Thymidine	5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others , DNA/RNA Synthesis , Endogenous Metabolite
	1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.		Others , DNA/RNA Synthesis , Endogenous Metabolite
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
TN5073	Strophanthidin	Strophanthidine	ATPase , Calcium Channel
	Strophanthidin (Strophanthidine) can induce calcium overload in vivo.		ATPase , Calcium Channel
T3415	Secoisolariciresinol diglucoside	LGM2605	ROS
	Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect ...		ROS
TN1086	Dehydrotrametenolic acid	Dehydroeburicoic acid	Apoptosis , TNF , NOS , Caspase , NO Synthase
	Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in human glioblastomas.		Apoptosis , TNF , NOS , Caspase , NO Synthase

天然物製品

Ammonium iron(III) citrate

T20819

Synonym: Ferric ammonium citrate

Target: Others, Ferroptosis

Thymidine

TWP2911

Synonym: 5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Pinostrobin

TN2082

Synonym:

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Strophanthidin

TN5073

Synonym: Strophanthidine

Target: ATPase, Calcium Channel

Secoisolariciresinol diglucoside

T3415

Synonym: LGM2605

Target: ROS

Dehydrotrametenolic acid

TN1086

Synonym: Dehydroeburicoic acid

Target: Apoptosis, TNF, NOS, Caspase, NO Synthase

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of ge...

AKT1 Protein, Human, Recombinant (His)

TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

TMPK-01170

Species: Mouse

Expression System: E. coli

カタログ番号	製品名
L9700	Endoplasmic Reticulum Stress Compound Library		193 compounds
	A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Endoplasmic Reticulum Stress Compound Library

L9700

Compounds: 193