|
T4188 |
SDZ285428
|
SDZ285-428 |
P450
,
Parasite
,
Antifungal
|
|
SDZ285428 is a CYP24A1 inhibitor. |
|
T0849 |
Pyrimethamine
|
Pirimecidan,RP 4753,Pirimetamin |
DHFR
,
Antifolate
,
Parasite
|
|
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug. |
|
T2279 |
Tizoxanide
|
Desacetyl-nitazoxanide,TIZ |
Antiviral
,
HIV Protease
,
Antibacterial
,
Autophagy
|
|
Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). |
|
T15173 |
DSM265
|
PfSPZ |
Dehydrogenase
,
Parasite
|
|
DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infectio... |
|
T1061 |
Toltrazuril
|
BAY-i 9142,Toltrazurilo,Baycox,Toltrazurilum |
Antibiotic
,
Parasite
|
|
Toltrazuril (Toltrazurilo), an antiprotozoal agent, has effect on Coccidia parasites. |
|
T0390 |
Aklomide
|
Alkomide,2-Chloro-4-nitrobenzamide |
Antibiotic
,
Parasite
|
|
Aklomide (2-Chloro-4-nitrobenzamide) is used in poultry to treat parasites. |
|
T7744 |
Piperaquine tetraphosphate tetrahydrate
|
|
Parasite
|
|
Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent. |
|
T20812 |
Azamethiphos
|
|
AChE
|
|
Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites. |
|
T6607 |
Nitenpyram
|
Niterndipoine,Bestguard,Capstar |
AChR
|
|
Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets. |
|
T5052 |
Toltrazuril (sulfone)
|
Toltrazuril sulfone,Ponazuril |
Parasite
|
|
Toltrazuril sulfone (Ponazuril) is an antiprotozoal agent that acts upon Coccidia parasites. |
|
T3361 |
Cambendazole
|
Bonlam,MK-905,Novazole |
Others
|
|
Cambendazole (Novazole) is one of the most effective agents for the therapy of human strongyloidiasis. Cambendazole is a nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses. |
|
T0951 |
Hydroxychloroquine sulfate
|
Acidum iopanoicum,HCQ sulfate |
DNA
,
SARS-CoV
,
TLR
,
Parasite
,
Autophagy
|
|
Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in ... |
|
T37072 |
Nitroxynil
|
4-Hydroxy-3-iodo-5-nitrobenzonitrile,Trodax,Dovenix |
Parasite
|
|
Nitroxynil (4-Hydroxy-3-iodo-5-nitrobenzonitrile) is an anthelmintic compound that effectively targets parasites in both adult and immature stages. It is extensively employed in investigations pertaining to Fasciola hepa... |
|
T28824 |
SNX0723
|
SNX 0723,SNX- 0723 |
HSP
|
|
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasit... |
|
T9549 |
Chiniofon
|
Loretin,Ferron,8-hydroxy-7-iodo-5-quinolinesulfonate,quiniophen |
Others
|
|
Chiniofon (Ferron), a halogenated 8-hydroxyquinoline, is used as an antiamebic drug. This type of anti-amebic drug exerts an anti-amebic effect by inhibiting intestinal commensal bacteria and affects amoebic dysentery, b... |
|
T33690 |
Nitroscanate
|
Lopatol,CGA-23654GS,CGA 23654 |
|
|
Nitroscanate is an anthelmintic found to be effective in certain strains of parasites in canines. |
|
T71841 |
MMV085203
|
|
|
|
MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites. |
|
T38729 |
Melarsonyl dipotassium
|
Melarsonic acid dipotassium |
|
|
Melarsonyl dipotassium, also known as melarsonic acid dipotassium, is a potent anthelmintic agent with the ability to effectively inhibit parasites. |
|
T70673 |
NEU617
|
|
|
|
NEU617 is an inhibitor of the growth of protozoan parasites, against T. brucei bloodstream proliferation. |
|
T14780 |
BRD9185
|
|
Dehydrogenase
|
|
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro. |
|
T37639 |
Toltrazuril sulfoxide
|
|
|
|
Toltrazuril sulfoxide, a transient intermediary metabolite of Toltrazuril, undergoes in vivo metabolism to yield the reactive toltrazuril sulfone (TZR-SO2). Toltrazuril functions as an antiprotozoal agent targeting Cocci... |
|
T10328 |
Anti-parasitic agent 3
|
|
Others
|
|
Anti-parasitic agent 3 is an anti-parasitic agent active against drug-resistant parasites. |
|
T40087 |
DSM502
|
|
|
|
DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs. |
|
T27400 |
Ganaplacide
|
KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156 |
|
|
Ganaplacide is an antimalarials with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. KAF156 showed antimalarial activity without evident safety concerns in a s... |
|
T70507 |
KAI-407
|
|
|
|
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing th... |
|
T40291 |
DSM705
|
DSM705 |
|
|
DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHO... |
|
T28937 |
Tebuquine
|
WR-228,258,WR 228,258,CI 897,CI897,CI-897 |
|
|
Tebuquine is an antimalarial agent. Tebuquine is active against P. falciparum in vitro. Tebuquine in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from th... |
|
T75331 |
Brilliant green
|
|
|
|
Brilliant green, a cationic dye, is utilized for coloring silk and wool. Additionally, it halts the propagation of mold, intestinal parasites, and fungus, proving effective against Gram-positive bacteria [1] [2]. |
|
T39256 |
MMV674850
|
MMV674850 |
|
|
MMV674850 exhibits potency against asexual stage parasites, with IC50 values of 2.7 and 4.5 nM. Furthermore, it demonstrates a preferential affinity for early-stage gametocytes, displaying an IC50 value of 4.5 ± 3.6 nM, ... |
|
T35740 |
FR900098 (sodium salt)
|
|
|
|
FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the... |
|
T62362 |
GNF6702
|
|
|
|
GNF6702 is a selective inhibitor of the kinetoplastid proteasome and has been shown to be effective against parasites in mouse models of leishmaniasis, Chagas disease and human African trypanosomiasis. |
|
T62550 |
DSM705 hydrochloride
|
|
|
|
DSM705 hydrochloride is a potent antimalarial compound and a pyrrole-based inhibitor of dihydroorotate dehydrogenase (DHODH).DSM705 hydrochloride shows nanomolar effects against PlasmodiumDHODH and Plasmodium parasites a... |
|
T79471 |
Antileishmanial agent-20
|
|
Parasite
|
|
Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1]. |
|
T74934 |
Trypanothione synthetase-IN-3
|
|
|
|
Trypanothione Synthetase-IN-3, a mixed noncompetitive inhibitor of Trypanothione Synthetase (TryS) with an inhibition constant (Ki) of 0.8 μM, is useful in researching parasites like L. infantum [1]. |
|
T61917 |
TCMDC-125457
|
|
|
|
TCMDC-125457 can effectively induce calcium redistribution, but has little effect on inhibiting heme crystallization. When TCMDC-125457 is combined with artesunate, it can effectively treat tightly synchronized artemisin... |
|
T72547 |
Plm IV inhibitor-2
|
|
|
|
Plm IV Inhibitor-2 is a powerful inhibitor of digestive vacuole plasmepsins IV (Plm IV), displaying IC50 values of 24 nM for Plm IV, 70 nM for Plm II, and 0.3 μM for Plm I. It is used in malaria research involving Plasmo... |
|
T12250 |
NPD-1335
|
|
Others
|
|
NPD1335, a potent inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibits submicromolar activity against T. brucei parasites and an improved cytotoxicity profile. By elevating intracellular cAMP levels,... |
|
T62677 |
Ganaplacide hydrochloride
|
|
|
|
Ganaplacide (KAF156) hydrochloride is a first-of-its-kind, orally active imidazolopiperazine antimalarial drug.Ganaplacide hydrochloride is active against a wide range of Plasmodium species, including drug-resistant para... |
|
T75536 |
Koshidacin B
|
|
|
|
Koshidacin B, a cyclic tetrapeptide, exhibits potent antiplasmodial activity, evidenced by its ability to inhibit Plasmodium falciparum strains FCR3 and K1 with IC50 values of 0.89 μM and 0.83 μM, respectively. It has be... |
|
T35732 |
Diacetylcercosporin
|
|
|
|
Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine and L. ... |
|
T38269 |
Purfalcamine
|
|
|
|
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala... |
|
T79277 |
Cysteine protease inhibitor-3
|
|
Parasite
|
|
Cysteine protease inhibitor-3 (Compound 15), a cysteine protease inhibitor, exhibits anti-plasmodial activity, effectively inhibiting Pf3D7 (IC50 = 0.74 μM), PfW2 (IC50 = 1.05 μM), PfFP2 (IC50 = 3.5 μM), and PfFP3 (IC50 ... |
|
T9763 |
MMV666810
|
|
|
|
MMV666810, a 2-aminopyrazine analogue of MMV390048, exhibits potent antiplasmodial activity against asexual parasites with an IC50 value of 5.94 nM. It demonstrates enhanced efficacy against late-stage gametocytes with a... |
|
T75338 |
Acridine Orange base
|
|
|
|
Acridine Orange Base, a cell-permeable fluorescent dye, selectively stains organisms (bacteria, parasites, viruses, etc.) bright orange and differentiates human cells in green under specific conditions (pH=3.5, Ex=460 nm... |
|
T74247 |
TPE-MI
|
|
|
|
Tetraphenylethene maleimide (TPE-MI) serves as a thiol probe to assess unfolded protein levels and proteostasis within cells. It is particularly effective in identifying proteostasis imbalances in both induced pluripoten... |
|
T65396 |
Piperazine 2HCl
|
|
|
|
Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspecte... |
