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カタログ番号 | 製品名 | 別名 | ターゲット |
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T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T2161 | Cardiogenol C | Wnt/beta-catenin | |
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. | |||
T8005 | Cardiogenol C hydrochloride | Cardiogenol C HCl,Cardiogenol C | Wnt/beta-catenin |
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). | |||
T7516 | ZD7288 | ICI D7288 | HCN Channel |
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. | |||
T3597 | Cutamesine dihydrochloride | AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride | Sigma receptor |
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr... | |||
T70064 | PDE1-IN-1 | ||
PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement pr... | |||
T62055 | NVS-BET-1 | ||
NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity. | |||
T76078 | Neurogranin (48-76), mouse | ||
Neurogranin (48-76), mouse, is a peptide comprising residues 48-76 of Neurogranin, a post-synaptically exclusive calmodulin-binding protein that mediates NMDAR-driven synaptic plasticity by regulating the calcium-calmodu... | |||
T70032 | NCI-006 | ||
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m... | |||
T62127 | AMPA-IN-1 | ||
AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14). | |||
T82673 | CPF-7 | Caerulein precursor fragment | |
CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti... | |||
T37388 | Afizagabar | ||
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy... | |||
TP2157L | TAT-DEF-Elk-1 TFA (1220751-16-5 free base) | TDE TFA,TAT-DEF-Elk-1 TFA | Others |
TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation withou... | |||
T76221 | Leptin (116-130) | ||
Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ... | |||
T81038 | TAT-DEF-Elk-1 TFA | TDE TFA | |
TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide that inhibits Elk-1 by mimicking its DEF domain and disrupting its function. It effectively blocks Elk-1 phosphorylation and its subsequent nuclear translocation,... | |||
T38169 | LY 341495 disodium salt | ||
Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 Fitzjohn et al (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mG... | |||
T36679 | Rp-cAMPS sodium salt | ||
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b... | |||
T37582 | Ganglioside GM1 Mixture (ovine) (ammonium salt) | ||
Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched i... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T82339 | Gangliotetraose | Gg4 | |
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
TMPJ-00135 | BDNF Protein, Human/Murine/Rat, Recombinant | Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I... | |||
TMPY-04779 | BTN3A2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tu... | |||
TMPY-02521 | HIST3H2A Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... | |||
TMPH-01770 | Neurotrypsin Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Neurotrypsin Protein, Human, Recombinant (His & SUMO) is expressed in... | |||
TMPH-03146 | LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) | Pongo abelii | E. coli |
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. Th... | |||
TMPH-02187 | Tenascin Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown o... | |||
TMPH-02278 | PTPN5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) i... | |||
TMPH-03379 | Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His) | Rat | E. coli |
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved ... | |||
TMPH-03380 | Synaptophysin/SYP Protein, Rat, Recombinant (His) | Rat | E. coli |
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptoph... | |||
TMPH-01036 | Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs... | |||
TMPY-01692 | NETO1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR... | |||
TMPK-01048 | Aggrecan Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articul... | |||
TMPH-01663 | GRM5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Sign... | |||
TMPH-01683 | Tau Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane com... | |||
TMPY-02106 | GAP43 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / G... | |||
TMPH-01754 | L1CAM Protein, Human, Recombinant (His & Myc) | Human | HEK293 Cells |
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neu... | |||
TMPJ-00295 | NgR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a recept... | |||
TMPY-03340 | MAP1LC3A Protein, Human, Recombinant (His) | Human | E. coli |
LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between mic... | |||
TMPJ-00883 | EGR1 Protein, Human, Recombinant (His) | Human | E. coli |
EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The produc... | |||
TMPY-03430 | RheB Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
RHEB is a recently discovered member of the Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins. RHEB gene is a member of the small GTPase ... | |||
TMPJ-00614 | CD47 Protein, Rhesus macaque, Recombinant (His & Flag) | Rhesus | HEK293 Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD)... | |||
TMPJ-00782 | Amyloid Precursor Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and... | |||
TMPY-04070 | Citrate Synthase Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Chondroitin sulphate (CS) glycosaminoglycan chains on cell and extracellular matrix proteoglycans (PGs) can no longer be regarded as merely hydrodynamic space fillers. Overwhelming evidence over recent years indicates th... | |||
TMPY-01992 | Kallikrein 8/KLK8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Ka... | |||
TMPY-01172 | CDH12 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic bi... | |||
TMPY-02001 | RTN4 Protein, Human, Recombinant (GST) | Human | E. coli |
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that... | |||
TMPY-01996 | SorCS1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
VPS1 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein that belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain.... | |||
TMPY-04408 | CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro... | |||
TMPY-02510 | HIST2H2BE Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and... |