|
T7045 |
Clonidine
|
Nexiclon,Catapres,Kapvay |
Adrenergic Receptor
|
|
Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide-scale use for many years, clonidine has not been l... |
|
T12643 |
(R)-Terazosin
|
|
Adrenergic Receptor
|
|
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). |
|
T6579 |
Medetomidine hydrochloride
|
MPV785,Medetomidine HCl,Domitor |
Adrenergic Receptor
|
|
Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. |
|
T0137 |
Mirtazapine
|
6-Azamianserin,Org3770 |
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... |
|
T10052 |
AR-08
|
|
Adrenergic Receptor
|
|
|
|
T27599 |
Imiloxan
|
RS-21361,RS 21361,RS21361 |
Adrenergic Receptor
|
|
Imiloxan (RS-21361) is an α2 adrenergic receptor antagonist used in the treatment of major depressive disorder. |
|
T26119 |
Romifidine
|
Romifidinum |
|
|
Romifidine is used as a sedative in veterinary medicine mainly in large animals such as horses. It acts as an agonist at the α2 adrenergic receptor subtype. |
|
T7065 |
Tizanidine
|
|
Adrenergic Receptor
|
|
Tizanidine, an α2-adrenergic receptor agonist, suppresses the release of neurotransmitters from central nervous system (CNS) noradrenergic neurons. |
|
T6766 |
Atipamezole
|
Antisedan,MPV 1248 |
Adrenergic Receptor
|
|
Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
|
T10100 |
QF0301B
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T11894 |
Lusaperidone
|
R107474 |
Adrenergic Receptor
|
|
Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively. |
|
T21371 |
Apraclonidine hydrochloride
|
Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum |
Adrenergic Receptor
|
|
Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glauco... |
|
T23397 |
ST 91
|
|
Others
,
Adrenergic Receptor
|
|
ST-91 is an agonist of α2-adrenoceptor with a mixed α-adrenergic receptor type/subtype selection profile. |
|
T0290 |
Tizanidine hydrochloride
|
Tizanidine HCl,DS 103-282 |
Adrenergic Receptor
|
|
Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons. |
|
T10998 |
Deriglidole
|
SL 86-0715 |
Adrenergic Receptor
|
|
Deriglidole (SL 86-0715) is a peripheral adrenergic receptor antagonist that is a selective inhibitor of alpha2 receptors. Deriglidole inhibits colistin and Idazoxan but does not show activity against prazosin and rat co... |
|
T16759 |
Ritanserin
|
R 55667 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. |
|
T34308 |
Rezatomidine
|
AGN-203818,AGN203818,AGN 203818 |
Adrenergic Receptor
|
|
Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain. |
|
T6765 |
Atipamezole hydrochloride
|
MPV-1248 hydrochloride,Antisedan |
Adrenergic Receptor
|
|
Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipa... |
|
T5954 |
Methyldopa hydrate
|
Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate |
Dopamine Receptor
,
Adrenergic Receptor
|
|
Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, ... |
|
T6464 |
Detomidine hydrochloride
|
MPV-253 AII,Domosedan,Detomidine HCl |
Adrenergic Receptor
|
|
Detomidine hydrochloride (MPV-253 AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors. |
|
T13804 |
OPC-28326
|
|
Adrenergic Receptor
|
|
OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively. |
|
T23382 |
Spiroxatrine
|
R 5188 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Spiroxatrine (R 5188) is a selective and potent 5-HT1α and α2-adrenergic dual antagonist with sedative activity and inhibitory effects on 5-HT1α, 5-HT1 β, 5-HT2, and dopamine receptors.Spiroxatrine may be used in the stu... |
|
T1247 |
Clonidine hydrochloride
|
Clonidine HCl,Catapres |
Adrenergic Receptor
|
|
Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent. |
|
T6522 |
Guanabenz Acetate
|
Wy8678 acetate,BR-750,Wytensin |
Adrenergic Receptor
|
|
Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively. |
|
T5471 |
GUANABENZ
|
|
Adrenergic Receptor
|
|
GUANABENZ is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanabenz is as an Adrenergic alpha2-Agonist. |
|
T68051L |
RS 15385-198
|
|
Adrenergic Receptor
|
|
RS 15385-198 is a less active isomer of Delequamine. Delequamine is a selective alpha2-adrenergic receptor antagonist. |
|
T12343 |
Benzquinamide
|
BZQ,P2647,Benzoquinamide |
Adrenergic Receptor
|
|
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzqui... |
|
T6466 |
Dexmedetomidine hydrochloride
|
Precedex,(+)-Medetomidine hydrochloride,(S)-Medetomidine hydrochloride,Dexmedetomidine HCl |
Adrenergic Receptor
|
|
Dexmedetomidine hydrochloride (Precedex) is an imidazole derivative that is an agonist of the adrenergic alpha-2 receptor. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound. |
|
T24064 |
Fipamezole
|
JP-1730,BVF-025,JP 1730,JP1730 |
Adrenergic Receptor
|
|
Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease. |
|
T2524 |
Dexmedetomidine
|
|
Adrenergic Receptor
|
|
Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia. |
|
T1275 |
Phentolamine mesylate
|
Phentolamine methanesulfonate,Phentolamine mesilate |
Adrenergic Receptor
|
|
Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS... |
|
T26651 |
ARC-239
|
ARC239,AR C 239,AR C239,AR C-239 |
|
|
ARC-239 is an agonist of α2-adrenergic receptor. |
|
T38192 |
Unifiram
|
|
Others
|
|
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... |
|
T11512 |
Guanoxabenz
|
Hydroxyguanabenz |
Others
|
|
|
|
T27340 |
Fluparoxan HCl
|
GR50360,GR 50360,Fluparoxan hydrochloride,GR-50360A,GR-50360 |
|
|
Fluparoxan is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). |
|
T13285 |
Vatinoxan hydrochloride
|
MK-467 hydrochloride,L-659066 hydrochloride |
Adrenergic Receptor
|
|
Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors. |
|
T28885 |
Sunepitron HCl
|
CP 93,393,CP93,393,CP-93393,CP93393,CP 93393,CP-93,393 |
|
|
Sunepitron is a combined α2-adrenergic receptor antagonist and 5-HT1A receptor agonist. |
|
T22719 |
Detomidine
|
|
Others
|
|
Detomidine is a nonnarcotic, synthetic α2-adrenergic agonist. Detomidine produces dose-dependent sedative and analgesic effects. |
|
T11272 |
Fenmetozole Tosylate
|
|
Others
|
|
Fenmetozole Tosylate , acts as an antidepressant drug. is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, |
|
T72240 |
Romifidine hydrochloride
|
|
|
|
Romifidine hydrochloride, an α2 adrenergic receptor agonist, induces sedation effects in vivo. |
|
T10264 |
AGN 192836
|
|
Others
|
|
|
|
T30108 |
Aptazapine maleate
|
CGS7525A,CGS-7525A,CGS 7525A |
|
|
Aptazapine (CGS 7525A) is a tetracyclic antidepressant (TECA) that is a potent α2-adrenergic receptor antagonist and has also been shown to act as a 5-HT2 receptor antagonist and an H1 receptor reverse agonist, both for ... |
|
T28131 |
Napamezole
|
WIN51181,WIN-51181,WIN 51181 |
|
|
Napamezole is an α2 adrenergic receptor antagonist. Napamezole antagonizes methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. Napamezole reverses clonidine-induced decreased in twitch... |
|
T19950 |
Paliperidone Palmitate
|
RO 92670,RO92670,RO-92670 |
|
|
Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications. Paliperidone has an antagonist effect at α1 and α2 adrenergic receptors and at H1 histamine receptors. In ad... |
|
T60548 |
Guanoxabenz hydrochloride
|
|
|
|
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an agonist of α2 adrenergic receptor. It has a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3]. |
|
T38146 |
Chloroguanabenz (acetate)
|
|
|
|
Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both so... |
|
T11010 |
Detomidine carboxylic acid
|
|
Adrenergic Receptor
|
|
Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect. |
|
T28417 |
Pipamperone HCl
|
fluoropipamide,floropipamide hydrochloride,carpiperone,floropipamide,R4050,Pipamperone |
|
|
Pipamperone acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It shows much higher affinity for the 5-HT2A and D4 receptors over the D2 receptor (15-fold in the c... |
|
T35591 |
Guanfacine-13C,15N3
|
Guanfacine-13C,15N3 |
|
|
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A... |
|
T62143 |
LP-922761 hydrate
|
|
|
|
LP-922761 hydrate is a selective, potent, orally active AAK1 inhibitor with IC50 values of 4.8 nM and 7.6 nM in enzyme and cellular assays, respectively. LP-922761 hydrate inhibits BMP-2 inducible protein kinase (BIKE) (... |
