|
T40315 |
γ-Secretase modulator 10
|
|
|
|
γ-Secretase modulator 10 is a novel γ-secretase modulator. |
|
T62263 |
γ-Secretase modulator 13
|
|
Gamma-secretase
|
|
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors. |
|
T11361 |
γ-Secretase modulator 4
|
|
Others
|
|
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively. |
|
T3521 |
γ-Secretase-IN-1
|
Compound E |
Beta Amyloid
,
Gamma-secretase
|
|
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage. |
|
T9422 |
Fosciclopirox
|
CPX-POM |
Gamma-secretase
|
|
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration. |
|
T16294 |
NGP555
|
|
Gamma-secretase
|
|
NGP555 is a modulator of γ-secretase. |
|
T6063 |
LY-411575
|
LY411575 |
Apoptosis
,
Gamma-secretase
|
|
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM. |
|
T6135 |
YO-01027
|
gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ |
Gamma-secretase
|
|
YO-01027 (DBZ) is a potent γ-secretase inhibitor. |
|
T2625 |
MK-0752
|
|
Beta Amyloid
,
Gamma-secretase
|
|
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM). |
|
T6249 |
Avagacestat
|
BMS-708163 |
Gamma-secretase
|
|
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
|
T3633 |
Crenigacestat
|
LY3039478 |
Gamma-secretase
|
|
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... |
|
T6870 |
L-685458
|
L-685,458 |
Apoptosis
,
Gamma-secretase
|
|
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. |
|
T16133 |
MRK-560
|
|
Gamma-secretase
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. |
|
T6274 |
RO4929097
|
RG-4733 |
Beta Amyloid
,
Gamma-secretase
|
|
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM). |
|
T6125 |
Semagacestat
|
LY450139 |
Beta Amyloid
,
Gamma-secretase
|
|
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM). |
|
T2262 |
Itanapraced
|
CHF5074,CSP-1103 |
Beta Amyloid
,
Gamma-secretase
|
|
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). |
|
T63216 |
γ-Secretase modulator 11
|
|
|
|
5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, was able to cause a significant reduction in b... |
|
T6202 |
DAPT
|
LY-374973,GSI-IX |
Apoptosis
,
Beta Amyloid
,
Gamma-secretase
,
Autophagy
|
|
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis. |
|
T61881 |
γ-Secretase modulator 12
|
|
|
|
γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretas... |
|
T63638 |
γ-Secretase modulator 11 hydrochloride
|
|
|
|
γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM). γ-Secretase modulator 11 hydrochloride significantly reduces brain Aβ42 levels and rescues the cognitive deficits ... |
|
T6935 |
Nirogacestat
|
PF-03084014,PF-3084014,PF03084014,PF 03084014 |
Apoptosis
,
Gamma-secretase
|
|
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay). |
|
T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
|
Compound W |
Gamma-secretase
|
|
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). |
|
T15184 |
E 2012
|
|
Gamma-secretase
|
|
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc... |
|
T11362 |
Gamma-Secretase Modulators
|
γ-Secretase Modulators,Amyloid-β production inhibitor |
Others
|
|
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value. |
|
T17281 |
Z-Ile-Leu-aldehyde
|
Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII |
Others
|
|
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch. |
|
T21890 |
JLK6
|
|
Gamma-secretase
|
|
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling |
|
T11358 |
Gamma-secretase modulator 1
|
N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine |
Gamma-secretase
|
|
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease. |
|
T10532 |
BI-1408
|
|
Others
,
Gamma-secretase
|
|
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42). |
|
T14690 |
BMS 433796
|
BMS-289948,BMS-299897 |
Beta Amyloid
|
|
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease. |
|
T9015 |
LY900009
|
|
Gamma-secretase
|
|
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. |
|
T14673 |
BMS 299897
|
|
Beta Amyloid
,
Gamma-secretase
|
|
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP). |
|
T9641 |
Aβ42-IN-2
|
|
Gamma-secretase
|
|
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1]. |
|
T11178L |
ELN318463 racemate
|
ELN318463 (racemate),ELN 318463 racemate |
Gamma-secretase
|
|
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor. |
|
T11043 |
Dihydroergocristine mesylate
|
DHEC (mesylate) |
Beta Amyloid
|
|
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebro... |
|
T39702 |
RO7185876
|
|
Gamma-secretase
|
|
RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease. |
|
T63208 |
Aβ-IN-1
|
|
Gamma-secretase
|
|
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma... |
|
T14680 |
BMS-906024
|
Osugacestat,AL-101,BM-0018 |
Gamma-secretase
|
|
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-... |
|
T4364 |
Aftin-4
|
Aftin 4,Aftin4 |
Beta Amyloid
,
Gamma-secretase
|
|
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... |
|
T2470 |
MDL-28170
|
Calpain Inhibitor III |
Cysteine Protease
,
Proteasome
|
|
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease. |
|
T13037 |
Sulindac sulfide
|
cis-Sulindac sulfide |
Raf
,
Others
,
AChR
|
|
Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibito... |
|
T11178 |
ELN318463
|
ELN 318463 |
Others
|
|
ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyl... |
|
T23431 |
TC-E 5006
|
|
Others
|
|
γ-secretase modulator |
|
T26864 |
BMS-932481
|
BMS932481 |
|
|
BMS-932481 is a γ-secretase modulator. |
|
T24116 |
GSM-1
|
gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K |
|
|
GSM-1 is a modulator of γ-Secretase. |
|
T10211 |
Aβ42-IN-1
|
|
Others
|
|
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 show... |
|
T11903 |
LY-411575 isomer 1
|
|
Others
|
|
LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575. |
|
T24210 |
JNJ-40418677
|
|
|
|
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch. |
|
T28735 |
SCH-900229
|
SCH 900229,SCH900229 |
|
|
SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer’s Disease. |
|
T24621 |
PF-06648671
|
PF 6648671,PF 06648671,PF6648671,PF-6648671 |
|
|
PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders. |
|
T27500 |
GSK-B
|
|
|
|
GSK-B, a potent γ-secretase modulator, decreases Aβ42, increases Aβ38 with no effect on Aβ40 levels. |
