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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T1889 | CP-640186 | CP 640186 | Acetyl-CoA Carboxylase |
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. | |||
T3622 | CP-640186 hydrochloride | CP 640186 HCl | Acetyl-CoA Carboxylase |
CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit... | |||
T6792 | BQ-123 | BQ123 | Endothelin Receptor |
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. | |||
T11831 | LDN-27219 | Others | |
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM. | |||
T8760 | NNMTi | 5-Amino-1-methylquinolinium | Others |
NNMTi (5-Amino-1-methylquinolinium) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adip... | |||
T3563 | Lvguidingan | Others | |
Lvguidingan is an Anticonvulsant agent. | |||
T8452 | Dantrolene | Others | |
Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. | |||
T5458 | Darusentan | Lu-135252 | Endothelin Receptor |
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries | |||
T23322 | SB 452533 | TRP/TRPV Channel | |
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). | |||
T22459 | Xanthinol Nicotinate | Angioamin,Complamin | Others |
Xanthinol Nicotinate (Complamin) is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased energy. | |||
T22967 | MEDICA16 | MEDICA 16 | GPR , Others , ATP Citrate Lyase |
Free fatty acid 1 (FFA1/GPR40) receptor agonist | |||
T0145 | Felodipine | CGH-869 | Calcium Channel , Autophagy |
Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor. | |||
T1594 | Vecuronium bromide | ORG NC 45 | AChR |
Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. | |||
T1072 | Loxeen | Pridinol methanesulfonate | AChR |
Loxeen (Pridinol methanesulfonate) is used as an anticholinergic and as an antiparkinsonian agent. | |||
T10492 | BD-AcAc 2 | Ketone Ester | Reactive Oxygen Species |
T22371 | Mivacurium dichloride | Mivacurium chloride | AChR |
Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emerg... | |||
T7764 | CCG-222740 | ROCK , Rho , Ras | |
CCG-222740 is an inhibitor of Rho/MRTF pathway | |||
T0992 | Carbenoxolone disodium | Biogastrone,Duogastrone,Bioral | Gap Junction Protein |
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ... | |||
T4993 | Afloqualone | HQ-495 | GABA Receptor |
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ... | |||
T7133 | Anagliptin | SK-0403 | Proteasome , DPP-4 |
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. | |||
T7144 | BTS | N-Tosylbenzylamine,N-Benzyl-p-toluenesulfonamide | ATPase , Myosin |
BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) . | |||
T1409 | Methocarbamol | Lumirelax,Metocarbamol,AHR 85,Robaxin | Sodium Channel , Carbonic Anhydrase |
Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful musc... | |||
T0096 | Vardenafil | Vivanza,Levitra,Vardenafil hydrochloride | PDE |
T8405 | Vardenafil hydrochloride | PDE | |
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes | |||
T8815 | Azumolene | EU4093 free base | Calcium Channel |
Azumolene (EU4093 free base) | |||
T1092 | Zolmitriptan | 311C90,BW-311C90 | 5-HT Receptor |
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... | |||
T8976 | PD-089828 | EGFR , FGFR , PDGFR , Src | |
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ... | |||
T6579 | Medetomidine hydrochloride | MPV785,Medetomidine HCl,Domitor | Adrenergic Receptor |
Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor. | |||
T2176 | 2,3-Butanedione 2-Monoxime | Diacetyl monoxime,2,3-Butanedione-2-monoxime | Akt |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction. | |||
T3461 | Losartan Carboxylic Acid | EXP-3174,E-3174 | RAAS |
Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l... | |||
T1487 | Fluvastatin sodium | XU 62320 sodium,XU-62-320,Fluvastatin sodium salt | Ferroptosis , HMG-CoA Reductase , Autophagy |
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. | |||
T4097 | Vardenafil hydrochloride trihydrate | Vardenafil HCl Trihydrate,BAY38-9456 | PDE |
Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T20789 | S-23 | (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 | Androgen Receptor |
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve... | |||
T1083L | Theophylline monohydrate | Quibron | HDAC , PDE , Adenosine Receptor |
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... | |||
T1826 | PI3K-IN-1 | Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 | DNA-PK , PI3K |
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | |||
T40101 | (±)-1,2-Diolein | 1,2-Dioleoyl-rac-glycerol | PKC |
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx. | |||
T4480 | Vardenafil dihydrochloride | Levitra,Vardenafil Hydrochloride | PDE |
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T67952 | JB062 | Myosin | |
JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It se... | |||
T67951 | JB061 | Myosin | |
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits l... | |||
T10421 | AVE5688 | Phosphorylase | |
AVE5688 is an inhibitor of glycogen phosphorylase (GP, IC50s: 430 nM and 915 nM; Kds: 170 nM and 530 nM for rmGPb and rmGPa). It can be used for the research of type 2 diabetes. | |||
T21550 | Blebbistatin | (±)-Blebbistatin | ATPase , Myosin |
Blebbistatin ((±)-Blebbistatin) is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell jun... | |||
T1650 | Chlorzoxazone | Paraflex,Chlorzoxazon | P450 , Potassium Channel |
Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation. | |||
T4054 | Dantrolene sodium hemiheptahydrate | Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,Sodium dantrolene | Calcium Channel , Autophagy |
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from t... | |||
T7843 | 4-phenoxypiperidine | Others | |
4-phenoxypiperidines with muscle relaxant and anticonvulsant activities. | |||
T1509 | Cyclobenzaprine hydrochloride | Cyclobenzaprine HCl,MK130 hydrochloride | 5-HT Receptor |
Cyclobenzaprine hydrochloride (MK130 hydrochloride) , a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms. | |||
T3618 | GSK-2881078 | GSK2881078,GSK 2881078 | Androgen Receptor |
GSK-2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function. | |||
T0077 | Dantrolene sodium | Lapatinib ditosylate monohydrate,Dantrolene sodium salt | Others , Calcium Channel |
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neu... | |||
T3996 | Dapiprazole Hydrochloride | Glamidolo Hydrochloride,Reversil Hydrochloride | Adrenergic Receptor |
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) is an alpha-1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointes... | |||
T4497 | Amifampridine | 3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine | Others |
Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is ... | |||
T0922 | Zoxazolamine | NSC 24995,Contrazole | Others |
Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8242 | Sabinene | Others | |
Sabinene is a natural product that has antifungal and anti-inflammatory properties | |||
T2S0820 | Karanjin | Apoptosis , AMPK | |
Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre... | |||
T1431 | Khellin | Amicardine,Methafrone,Visammin | EGFR , Others |
Khellin (Methafrone) is a vasodilator that also has bronchodilatory action. | |||
TN1084 | 1,3,5,8-Tetrahydroxyxanthone | Desmethylbellidifolin | Anti-infection |
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity. Dimethylbellidifolin show... | |||
T1083 | Theophylline | Theo-24,1,3-Dimethylxanthine | Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy |
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3... | |||
T3S0364 | L-Arginine | L-Arg,(S)-(+)-Arginine | IL Receptor , Endogenous Metabolite , NO Synthase |
1. L-Arginine (L-Arg) exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. 3. Exogenous L-Arginine could enhance neonate... | |||
T8288 | 14-Deoxyandrographolide | Apoptosis , Others | |
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. | |||
T2207 | Adrenosterone | 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G | Androgen Receptor , Endogenous Metabolite |
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex. | |||
T2S1464 | Thiocolchicoside | Thiocolchicine 2-glucoside analog,Coltramyl | Others , GABA Receptor |
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece... | |||
T6060 | (±) Anabasine | Endogenous Metabolite | |
(±) Anabasine is a muscle relaxant that can be used for muscle relaxation during surgery. | |||
TN1248 | 3-Epioleanolic acid | AChR | |
3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle. | |||
T38022 | 2,6-Dibromophenol | 2,6-Dibromo-phenol | Endogenous Metabolite |
2,6-Dibromophenol (2,6-Dibromo-phenol) is extracted from the skin and muscle of flatfish. | |||
T5294 | (S)-Leucic acid | L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-(−)-2-Hydroxyisocaproic acid | Others , Endogenous Metabolite |
(S)-Leucic acid (Hydroxyisocaproic acid) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. It belongs to 2-hydroxycarboxylic acid group of amino acid metabolites. (S)-Leucic a... | |||
T2520 | Desloratadine | Sch34117,NSC 675447 | Endogenous Metabolite , Histamine Receptor |
Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smoot... | |||
T4888 | Phosphocreatine disodium hydrate | Phosphocreatine disodium salt hydrate | Others , Endogenous Metabolite |
Phosphocreatine disodium hydrate ishigh-energy phosphate reservoir in vertebrate and some invertebrate muscle; provides phosphate for ADP-ATP conversion | |||
T8178 | Acetagastrodin | Acegastrodine | Others |
Acetagastrodin (Acegastrodine) has an antispasmodic effect on vascular smooth muscle. | |||
TN1819 | Kaempferol 3-neohesperidoside | Kaempferol 3-O-neohesperidoside | GSK-3 , MEK , PI3K |
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle. | |||
T4592 | TOMATIDINE HYDROCHLORIDE | Tomatidine,Tomatidine HCl | Others , NF-κB , JNK , Autophagy |
Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatid... | |||
T0496 | Creatinine | NSC13123 | Endogenous Metabolite |
Creatinine (NSC-13123) is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function. | |||
T22300 | Creatine monohydrate | Methylguanidoacetic acid monohydrate | Others , Endogenous Metabolite |
Creatine monohydrate (Methylguanidoacetic acid monohydrate) is a key player in the phosphagen energy system, especially in muscle and the brain. Creatine monohydrate is the primary source of ATP during high-intensity, sh... | |||
T3A2467 | Allocryptopine | Thalictrimine,Fagarine I | Potassium Channel |
Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively. | |||
T15716 | Lasalocid sodium | Ionophore X-537A sodium,Antibiotic X-537A sodium,Lasalocid-A sodium | Antibacterial , Antibiotic , Autophagy |
Lasalocid sodium (Lasalocid-A sodium) is a cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. Lasalocid sodium is used as a co... | |||
TN1683 | Gentisin | DNA/RNA Synthesis | |
Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity. | |||
T3O2749 | L-Leucine | (S)-Leucine,Leu | mTOR |
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar lev... | |||
T8771 | Pongamol | Others | |
Pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and GLUT4 translocation in skeletal muscle cells. | |||
T5S1408 | Pteryxin | (+)-Pteryxin | Others , AChE |
(+)-Pteryxin ((+)-Pteryxin) has muscle-relaxant props. (+)-Pteryxin shows hepatoprotective and nitric oxide prodn. inhibitory activity. | |||
T4765 | L-Norleucine | (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid | Influenza Virus , Endogenous Metabolite |
L-Norleucine ((S)-Norleucine) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity. | |||
T7912 | (−)-Myrtenal | (1R)-(−)-Myrtenal | Others |
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. | |||
T4333 | Quinine dihydrochloride | Quinine bimuriate | Others |
Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). | |||
T0739 | Guaifenesin | Glycerol guaiacolate,Guaiacol glyceryl ether,Guaiphenesin | Others |
Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations. | |||
T4732 | L-Carnosine | Karnozin,beta-Alanyl-L-histidine | Antioxidant , Endogenous Metabolite |
L-Carnosine (Karnozin) is is an antioxidant naturally found in skeletal muscle, brain tissue. It has the potential to suppress many of the biochemical changes that accompany aging. | |||
T2O2776 | L-Valine | Others , Endogenous Metabolite | |
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway. | |||
T3262 | Phosphocreatine disodium | Disodium phosphocreatine,Phosphocreatine disodium salt,Creatine phosphate disodium salt | Others , Endogenous Metabolite |
Phosphocreatine disodium (Phosphocreatine disodium salt) is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in muscle, skeletal, and brain. | |||
T0743 | DL-Carnitine | Carnitina,Carnitine | Others |
DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias. | |||
T4934 | 1-Methyl-L-histidine | 3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine | Endogenous Metabolite |
1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown. | |||
T3805 | Prim-O-glucosylcimifugin | Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside | TNF , COX , JAK , NO Synthase |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase. | |||
T20604L | Litorin acetate(55749-97-8 Free base) | Bombesin Receptor | |
Litorin acetate, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. It stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the n... | |||
T2917 | Tetrahydropalmatine hydrochloride | 1-Tetrahydropalmitine HCl,Gindarine hydrochloride | Others , Dopamine Receptor |
Tetrahydropalmatine hydrochloride (Gindarine hydrochloride) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo). It is a potent muscle relaxant. | |||
T4842 | 1H-pyrazole | 1,2-Diazole,Pyrazole | Others , Endogenous Metabolite |
1H-pyrazole (1,2-Diazole), is a versatile building block, with a vast applications in organic synthesis. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythm... | |||
T6S1418 | Praeruptorin C | Antioxidant , Calcium Channel | |
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... | |||
T3S0195 | Nootkatone | AMPK | |
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activa... | |||
T2203 | D-Carnitine hydrochloride | (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride | Others , Endogenous Metabolite |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) is a constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemi... | |||
T6S2025 | 8-O-Acetylharpagide | 8-Acetylharpagide,3-Acetylharpagide,Acetylharpagide,8-O-Acetylharpagide | Antibacterial |
1. 8-O-Acetylharpagide has anti-inflammatory activity. 2. 8-O-Acetylharpagide has antibacteria and antiviral activities. 3. 8-O-Acetylharpagide has a biological activity on isolated smooth muscle preparations from guinea... | |||
T4739 | Sodium creatine phosphate dibasic tetrahydrate | Creatine phosphate disodium salt tetrahydrate | Others , Endogenous Metabolite |
Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) mainly exists in the skeletal muscles of vertebrates. It is a substrate for the determination of creatine kinase and can be u... | |||
T6102 | 2'-acetylacteoside | Antioxidant , Reductase | |
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo... | |||
T6534 | Histamine dihydrochloride | peremin,Ceplene,Histamine 2HCl | Endogenous Metabolite , Histamine Receptor |
Histamine dihydrochloride (Ceplene) is dihydrochloride form of Histamine. Histamine is an organic nitrogen compound which is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodila... | |||
PDK0014 | 3-Methylxanthine | Endogenous Metabolite | |
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could ... | |||
T0965 | Histamine | Ergamine | 5-HT Receptor , Endogenous Metabolite , Histamine Receptor |
Histamine (Ergamine) is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting ne... | |||
T5014 | Prostaglandin E2 | PGE2,Dinoprostone,Prostaglandin E2 (PGE2) | Endogenous Metabolite , Prostaglandin Receptor |
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, re... | |||
T5562 | Methyl nicotinate | methyl pyridine-3-carboxylate | Others |
Methyl nicotinate (methyl pyridine-3-carboxylate) is the methyl ester of that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of m... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02499 | Cofilin 2 Protein, Human, Recombinant (His) | Human | E. coli |
Cofilin 2 (muscle), also known as CFL2, is a member of cofilin family of the actin-binding protein superfamily. Cofilin2 shows significant homology to the other two members: cofilin 1 and DSTN, through its entire sequenc... | |||
TMPY-03446 | ENO3 Protein, Human, Recombinant (His) | Human | E. coli |
ENO3 is one of the three enolase isoenzymes found in mammals. As a homodimer, ENO3 is found in skeletal muscle cells in the adult. A switch from alpha enolase to beta enolase occurs in muscle tissue during development... | |||
TMPY-04557 | PHKG1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. P... | |||
TMPY-04762 | CKM Protein, Human, Recombinant (His) | Human | E. coli |
CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissu... | |||
TMPY-02298 | ACYP2 Protein, Human, Recombinant (GST) | Human | E. coli |
Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to c... | |||
TMPY-04414 | MUSK Protein, Human, Recombinant (aa 433-783, His & GST) | Human | Baculovirus-Insect Cells |
Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the p... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... | |||
TMPY-03607 | Cofilin Protein, Human, Recombinant (His) | Human | E. coli |
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments t... | |||
TMPH-00881 | ACTA1 Protein, Human, Recombinant (His) | Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | |||
TMPH-02547 | ENO3 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Appears to have a function in striated muscle development and regeneration. | |||
TMPY-03438 | Calsequestrin 1 Protein, Human, Recombinant | Human | E. coli |
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction,... | |||
TMPH-02546 | ENO3 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Appears to have a function in striated muscle development and regeneration. | |||
TMPY-02223 | GSTM2 Protein, Human, Recombinant (His) | Human | E. coli |
Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-te... | |||
TMPH-01032 | Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inh... | |||
TMPH-02662 | Aldolase A Protein, Mouse, Recombinant (His) | Mouse | Baculovirus |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. | |||
TMPJ-00384 | PFKM Protein, Human, Recombinant (His) | Human | Human Cells |
6-phosphofructokinase, muscle type is a muscle-type isozyme that in humans is encoded by the PFKM gene. It belongs to the phosphofructokinase family and Two domains subfamily. PFKM functions as subunits of the mammalian ... | |||
TMPY-04766 | PKM2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ... | |||
TMPY-04479 | PFKM Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-ty... | |||
TMPY-04465 | PKM2 Protein, Human, Recombinant (His) | Human | E. coli |
Pyruvate kinase isozymes M2 also known as pyruvate kinase muscle isozyme 2 (PKM2), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting ... | |||
TMPH-02663 | Aldolase A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. | |||
TMPH-00882 | ACTA2 Protein, Human, Recombinant (His) | Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | |||
TMPH-01357 | ALDOA Protein, Human, Recombinant (His) | Human | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. | |||
TMPJ-00696 | NOL3 Protein, Human, Recombinant | Human | E. coli |
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in... | |||
TMPH-01210 | DENR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes.... | |||
TMPJ-00697 | NOL3 Protein, Human, Recombinant (GST) | Human | E. coli |
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in... | |||
TMPJ-00724 | LDHA Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,... | |||
TMPH-01176 | CSRP3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00780 | CACNA1C Protein, Guinea Pig, Recombinant (His) | Guinea pig | in vitro E. coli expression system |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm... | |||
TMPY-04826 | LILRB5/CD85c Protein, Human, Recombinant (His) | Human | HEK293 |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) le... | |||
TMPY-05030 | PCDH7 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cance... | |||
TMPY-00654 | ACVR2B Protein, Human, Recombinant (hFc) | Human | HEK293 |
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of ... | |||
TMPY-01281 | ACVR2B Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of ... | |||
TMPY-01146 | Insulin Receptor Protein, Human, Recombinant (long isoform, His) | Human | HEK293 |
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta... | |||
TMPJ-01210 | IL-33 Protein, Mouse, Recombinant | Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi... | |||
TMPY-03382 | FGF-6 Protein, Human, Recombinant | Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, includi... | |||
TMPY-02031 | B7-H3 Protein, Human, Recombinant (His) | Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei... | |||
TMPY-04064 | B7-H3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei... | |||
TMPY-04262 | B7-H3 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei... | |||
TMPY-02813 | ErbB4 Protein, Human, Rhesus, Recombinant (His) | Human,Rhesus | HEK293 |
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ... | |||
TMPY-05641 | B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei... | |||
TMPY-04645 | TL1A Protein, Human, Recombinant (hFc) | Human | HEK293 |
TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, ... | |||
TMPJ-00139 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His) | Human | E. coli |
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain... | |||
TMPJ-00261 | TGF beta 2 Protein, Mouse/Rat, Recombinant | Mouse,Rat | Human Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci... | |||
TMPJ-00562 | PDGF-BB Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P... | |||
TMPY-01008 | VEGFD Protein, Human, Recombinant (His) | Human | HEK293 |
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active... | |||
TMPY-05004 | FGF-4 Protein, Human, Recombinant | Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati... | |||
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPY-03120 | Prostaglandin D2 Synthase Protein, Human, Recombinant (His) | Human | HEK293 |
PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic mole... | |||
TMPY-02500 | YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c... | |||
TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
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A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; | |||
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A unique collection of 1428 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
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A unique collection of 908 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. |