Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 40,500 | |||
50 mg | 在庫あり | ¥ 59,000 | |||
100 mg | 在庫あり | ¥ 87,000 | |||
500 mg | 在庫あり | ¥ 205,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA). |
ターゲット&IC50 | MAGL (human):5.9 nM, MAGL (rat):43 nM, MAGL (mouse):15 nM, 2-AG:2.5 nM, AEA:>50 μM |
In vivo | DprE1-IN-2 has efficacy in a rodent model of tuberculosis. |
分子量 | 549.42 |
分子式 | C24H21F6NO7 |
CAS No. | 1380424-42-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (91 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KML29 1380424-42-9 Metabolism Lipase LPS KML 29 allodynia Monoacylglycerol lipase MAGL inhibit 2-AG Inhibitor HFIP KML-29 inhibitor