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TQ0311 |
GSK163090
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|
Dopamine Receptor
,
5-HT Receptor
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GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
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T8737 |
GR 125743
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5-HT Receptor
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GR 125743 is a novel antagonist of 5-HT1B/1D receptor. |
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T0203 |
Sumatriptan succinate
|
GR 43175 |
5-HT Receptor
|
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Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. |
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T11326 |
Frovatriptan succinate hydrate
|
Frovelan,Frova |
5-HT Receptor
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|
Frovatriptan succinate hydrate (Frova) is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatriptan succinate hydrate can also b... |
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T6423 |
BRL-15572 dihydrochloride
|
BRL 15573 dihydrochloride |
5-HT Receptor
|
|
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto... |
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T2688 |
LY310762
|
LY310762 HCl |
5-HT Receptor
|
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LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
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T11075 |
Donitriptan
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5-HT Receptor
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Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively. |
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T12861 |
SB-277011
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SB-277011A |
Dopamine Receptor
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SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively. |
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T22808 |
GR 46611
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5-HT Receptor
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GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy. |
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T6602 |
Naratriptan hydrochloride
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Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride |
5-HT Receptor
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Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... |
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T22689 |
CP94253 hydrochloride
|
CP 94253 hydrochloride |
Others
,
5-HT Receptor
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CP94253 hydrochloride (CP 94253 hydrochloride) is a potent, selective and centrally active agonist of 5-HT1B receptor with Ki of 2 nM. The Kis are 89, 49, 860, and 1600 nM for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, ... |
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T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
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Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
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T34081 |
Piromelatine
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NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
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T23265 |
RS 67333 hydrochloride
|
RS 67333 (hydrochloride),RS 67333 HCl |
5-HT Receptor
|
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RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, inclu... |
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T4118 |
SB 271046 hydrochloride
|
SB 271046A |
5-HT Receptor
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|
SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and ... |
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T1092 |
Zolmitriptan
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311C90,BW-311C90 |
5-HT Receptor
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Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... |
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T16556 |
PNU-142633
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5-HT Receptor
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PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively). |
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T23405 |
Sumatriptan
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Others
|
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Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards 5-HT1D, 5-HT1B, and 5-HT1A. |
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T26598 |
Alniditan dihydrochloride
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|
|
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Alniditan dihydrochloride is a potent 5-HT1D agonist and migraine-abortive agent. |
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T12861L |
SB-277011 dihydrochloride
|
SB-277011A dihydrochloride |
Dopamine Receptor
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|
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
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T28679 |
SB 714786
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SB-714786,SB714786 |
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SB 714786 is a selective antagonist of 5-HT1D. |
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T22901 |
L-703,664 succinate
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Others
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L-703,664 succinate is a 5-HT1D receptor agonist. |
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T27432 |
GR-55562 dihydrobromide
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GR 55562 dihydrobromide |
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GR-55562 dihydrobromide is a antagonist of 5-HT1B/5-HT1D serotonin receptor. |
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T27879 |
LY 165163
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LY-165,163,LY165,163,LY 165,163 |
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LY-165163 is a selective antagonists of 5-HT1A and 5-HT1D serotonin receptor. |
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T0216 |
Eletriptan hydrobromide
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Eletriptan HBr,UK-116044 |
5-HT Receptor
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Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor. |
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T19701 |
L-694,247
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|
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L-694,247 is a selective and extremely potent agonist of the 5-HT1D receptor. |
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T10380 |
AS19
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5-HT Receptor
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AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). |
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T22681 |
CP 135807
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Others
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CP 135807 is a 5-HT1D receptor agonist. |
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T27628 |
IS-159
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IS 159,IS159 |
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IS-159, a 5-HT1D agonist, is used potentially for the treatment of migraine. |
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T31617 |
Elzasonan citrate
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Elzasonan Citrate is a selective 5-HT1B and 5-HT1D receptor antagonist for the treatment of depression. |
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T10360 |
AR-A 2
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AR-A 000002 |
Others
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AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D... |
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T27059 |
CP-122288
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CP-122288 is a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. CP-122288 is potent as an inhibitor of plasma protein extravasation and neurogenic inflammation. |
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T28431 |
PNU109291
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PNU-109291,PNU 109291 |
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PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation. |
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T36063 |
N-desmethyl Zolmitriptan
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|
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N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan . DZT is an agonist of 5-HT1B receptors that induces contraction of isolated human ce... |
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T35104 |
Way 100135
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Way-100135,Way100135 |
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Way 100135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research. It acts as a potent 5-HT1A receptor antagonist and a partial agonist of the 5-HT1D receptor, and to a much lesser ext... |
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T19690 |
SB 224289
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SB224289,SB-224289 |
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SB 224289 is a selective antagonist of 5-HT1B receptor with pKi of 8.2. It is a centrally active following oral administration in vivo. SB 224289 displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A a... |
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T71211 |
Rizatriptan-d6 benzoate salt
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Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin
receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-H... |
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T2459 |
BRL 54443
|
BRL54443 |
5-HT Receptor
|
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BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively). |
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T60989 |
Sumatriptan hydrochloride
|
|
|
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Sumatriptan (GR 43175) hydrochloride can be used in the research of migraine headache that is an orally active agonist of 5-HT1 receptor. The Ki values of Sumatriptan hydrochloride against 5-HT1D, 5-HT1B and 5-HT1A rece... |
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T63096 |
SB-277011 hydrochloride
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|
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SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally active, dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier with Ki values of 10.7 nM and 11.2 nM for rodent and hu... |
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T12899L |
SEP-363856 hydrochloride
|
SEP-856 hydrochloride |
Others
,
5-HT Receptor
|
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SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to trea... |
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T11827 |
Pradigastat
|
ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase
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Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. |
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T8720 |
PRX-07034 hydrochloride
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PRX-07034 |
5-HT Receptor
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PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 hydrochloride is both a poten... |
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T14190 |
Alniditan
|
Alnitidan |
5-HT Receptor
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Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. |
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T12899 |
SEP-363856
|
SEP-856 |
Others
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SEP-363856 is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. |
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T40439 |
Sarizotan
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EMD 128130 |
|
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Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors. It has shown potent activity with IC 50 values of 6.5 nM for rat 5-HT 1A , 0.1 nM for hu... |
