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カタログ番号 | 製品名 | 別名 | ターゲット |
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T10636 | 5α-reductase-IN-1 | Others | |
5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in com... | |||
T0488 | Finasteride | MK-906 | Reductase |
Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM. | |||
T33414 | MK 0434 | MK0434,MK434,MK 434,MK-0434,MK-434 | |
MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT. | |||
T71703 | Turosteride | Reductase | |
Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and genitourinary disorders, and may be used in the study of pros... | |||
T30150 | AS-601811 | AS601811,AS 601811,UNII-LIV8A6AE5F | Androgen Receptor |
AS-601811 is a steroidal 5α-reductase inhibitor and androgen receptor modulator used to study hair loss and acne. | |||
T27798 | Lapisteride | CS891B,CS-891,CS-891B,CS891 | Others |
Lapisteride (CS-891) a steroidal 5α-reductase inhibitor is used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia and may be effective in preventing or treating AGA . | |||
T67901 | SRD5A1-IN-1 | Others | |
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression. | |||
T1499 | Dutasteride | GG 745,Avodart,GI 198745 | Apoptosis , Reductase |
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. | |||
T27643 | Izonsteride | LY-320236,LY320236,UNII-A5E8C36F34 | Reductase |
Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, ... | |||
T71703L | Isomer-Turosteride | Isomer-Turosteride(Isomer-137099-09-3) | Reductase |
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to ... | |||
T27889 | LY191704 | LY 191704,LY-191704 | |
LY 191704 is a 5α-reductase type 1 inhibitor. | |||
T28956 | TF-505 | FR-146687,FK-687,TF 505,FK687 | |
TF-505, a steroid 5α-reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia. | |||
T2195L | Epiandrosterone Sulfate | Epiandrosterone 16-bromo,Epiandrosterone | |
Epiandrosterone sulfate is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase of the adrenal hormone DHEA. | |||
T21668 | Finasteride acetate | ||
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC 50 of 4.2 nM for type II 5α-reductase. The affinity of Finasteride acetate for type II 5α-reductase enzyme was approximately 100... | |||
T28280 | Oxendolone | Roxenone,Prostetin | |
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reducta... | |||
T38442 | 17,17-(Ethylenedioxy)androst-4-en-3-one | ||
17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)... | |||
T9660 | Bexlosteride | ||
Bexlosteride (LY300502), a benzoquinolinone derivative, functions as a human type I 5α-reductase inhibitor. It demonstrates metabolic inhibition, antiproliferative, and antisecretory activities specifically in LNCaP huma... | |||
T73410 | MK-4541 | ||
MK-4541 is an orally active, selective androgen receptor (AR) modulator that serves as an antagonist to inhibit 5α-reductase. It effectively inhibits proliferation and induces apoptosis in AR-positive prostate cancer cel... | |||
T10780 | CGP-53153 | Others | |
T22672 | Cl-4AS-1 | Others | |
steroidal androgen receptor agonist |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN2601 | 12-O-Methylcarnosic acid | Reductase | |
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity... | |||
T3378 | Alpha-Estradiol | Alfatradiol,17α-Estradiol,Epiestrol,Epiestradiol | Estrogen/progestogen Receptor , Reductase , Endogenous Metabolite |
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia. | |||
T3329 | 4',7-Dimethoxyisoflavone | Dimethoxydaidzein,Daidzein dimethyl ether | Endogenous Metabolite , Antifungal |
4',7-Dimethoxyisoflavone (Daidzein dimethyl ether) , a kind of isoflavonoids, showed inhibitory effects on rat prostate testosterone 5α-reductase. | |||
T5S0543 | Isocurcumenol | Apoptosis , Estrogen Receptor/ERR , Reductase | |
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT). | |||
T75674 | Pedunculagin | ||
Pedunculagin, a potent 5α-reductase type 1 inhibitor, effectively inhibits the production of nitric oxide (NO), IL-6, and IL-8 while also decreasing the protein expression of 5α-reductase. Additionally, it exhibits anti-... | |||
TN4164 | Grandifloroside | TNF | |
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti... | |||
TN5153 | Torilin | MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK | |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi... |