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Search Results for " 5α-reductase "

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20

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7

天然化合物

カタログ番号 製品名 別名 ターゲット
T10636 -reductase-IN-1 Others
-reductase-IN-1 is a potent inhibitor of the enzyme -reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in com...
T0488 Finasteride MK-906 Reductase
Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.
T33414 MK 0434 MK0434,MK434,MK 434,MK-0434,MK-434
MK 0434 is a steroid -reductase inhibitor and hormone antagonist associated with a significant reduction in DHT.
T71703 Turosteride Reductase
Turosteride is a small molecule steroidal -reductase (-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and genitourinary disorders, and may be used in the study of pros...
T30150 AS-601811 AS601811,AS 601811,UNII-LIV8A6AE5F Androgen Receptor
AS-601811 is a steroidal -reductase inhibitor and androgen receptor modulator used to study hair loss and acne.
T27798 Lapisteride CS891B,CS-891,CS-891B,CS891 Others
Lapisteride (CS-891) a steroidal -reductase inhibitor is used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia and may be effective in preventing or treating AGA .
T67901 SRD5A1-IN-1 Others
SRD5A1-IN-1 is an inhibitor of steroid -reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.
T1499 Dutasteride GG 745,Avodart,GI 198745 Apoptosis , Reductase
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
T27643 Izonsteride LY-320236,LY320236,UNII-A5E8C36F34 Reductase
Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, ...
T71703L Isomer-Turosteride Isomer-Turosteride(Isomer-137099-09-3) Reductase
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to ...
T27889 LY191704 LY 191704,LY-191704
LY 191704 is a -reductase type 1 inhibitor.
T28956 TF-505 FR-146687,FK-687,TF 505,FK687
TF-505, a steroid -reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia.
T2195L Epiandrosterone Sulfate Epiandrosterone 16-bromo,Epiandrosterone
Epiandrosterone sulfate is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme -reductase of the adrenal hormone DHEA.
T21668 Finasteride acetate
Finasteride (MK-906) acetate is a potent and competitive -reductase inhibitor, with an IC 50 of 4.2 nM for type II -reductase. The affinity of Finasteride acetate for type II -reductase enzyme was approximately 100...
T28280 Oxendolone Roxenone,Prostetin
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of -reducta...
T38442 17,17-(Ethylenedioxy)androst-4-en-3-one
17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)...
T9660 Bexlosteride
Bexlosteride (LY300502), a benzoquinolinone derivative, functions as a human type I -reductase inhibitor. It demonstrates metabolic inhibition, antiproliferative, and antisecretory activities specifically in LNCaP huma...
T73410 MK-4541
MK-4541 is an orally active, selective androgen receptor (AR) modulator that serves as an antagonist to inhibit -reductase. It effectively inhibits proliferation and induces apoptosis in AR-positive prostate cancer cel...
T10780 CGP-53153 Others
T22672 Cl-4AS-1 Others
steroidal androgen receptor agonist
カタログ番号 製品名 別名 ターゲット
TN2601 12-O-Methylcarnosic acid Reductase
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of -Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...
T3378 Alpha-Estradiol Alfatradiol,17α-Estradiol,Epiestrol,Epiestradiol Estrogen/progestogen Receptor , Reductase , Endogenous Metabolite
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
T3329 4',7-Dimethoxyisoflavone Dimethoxydaidzein,Daidzein dimethyl ether Endogenous Metabolite , Antifungal
4',7-Dimethoxyisoflavone (Daidzein dimethyl ether) , a kind of isoflavonoids, showed inhibitory effects on rat prostate testosterone -reductase.
T5S0543 Isocurcumenol Apoptosis , Estrogen Receptor/ERR , Reductase
1. Isocurcumenol inhibits -reductase which converts testosterone to dihydrotestosterone (DHT).
T75674 Pedunculagin
Pedunculagin, a potent -reductase type 1 inhibitor, effectively inhibits the production of nitric oxide (NO), IL-6, and IL-8 while also decreasing the protein expression of -reductase. Additionally, it exhibits anti-...
TN4164 Grandifloroside TNF
Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and -reductase, suggests that it might be developed as a source of potent anti...
TN5153 Torilin MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi...