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Search Results for " Forskolin "

37

阻害剤

6

天然化合物

カタログ番号 製品名 別名 ターゲット
T24365 L 858051 7B-Forskolin,L858051,Dmpb-forskolin,L-858051
L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes.
T22467 1,9-Dideoxyforskolin Others
The compound is an inactive analog of forskolin(an adenylyl cyclase activator).
T36720 Deacetylforskolin
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos...
T39442 AM-8123
AM-8123 is an APJ agonist with high oral bioavailability and potency. It effectively inhibits Forskolin-stimulated cAMP production and activates Gα proteins. This compound is valuable for cardiovascular disease research.
T16516 PG01 Phenylglycine-01 CFTR
TP2092L Apelin-17 (human, bovine) acetate Apelin-17 (human, bovine) acetate(217082-57-0 free base) HIV Protease
Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
TP1922L1 ELA-11 (human) acetate(1784687-32-6 free base) Apelin receptor , Arrestin
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
TP1936L1 RFRP3(human) acetate(311309-27-0 free base) Neuropeptide Y Receptor
RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced produ...
T39392L C-Type Natriuretic Peptide (CNP) (1-22), human acetate C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base) Others
C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), huma...
TP1187 C-Type Natriuretic Peptide (CNP) (1-22), human CNP (1-22), human RAAS
C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.
T10591L (R)-BPO-27 CFTR , Autophagy
(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.
T78083 CB-25 Cannabinoid Receptor
CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells [1].
T33214 Manoyl oxide Manoyl
Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.
T27779 L-759,656 L 759,656,L759,656
L-759,656 is highly selective CB2 receptor agonist (CB1 Ki = 4888 nM, CB2 Ki = 11.8 nM). L-759,656 potently inhibits forskolin-stimulated cAMP production in CHO cells (EC50 = 3.1 nM).
TP2092 Apelin-17(human, bovine) Apelin-17 (human, bovine)
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
TP1922 ELA-11(human) ELA-11 (human)
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
T76053 ELA-11(human) TFA
ELA-11(human) TFA, a bioactive fragment of ELA-32, acts as a high-affinity apelin receptor agonist (K i =14 nM). It effectively inhibits forskolin-induced cAMP production and promotes β-arrestin recruitment in vitro, hig...
TP1936 RFRP-3(human) RFRP 3 (human)
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
TP2001 MM 54
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv...
T78949 AM841 Cannabinoid Receptor
AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi...
TP2096 ELA-21 (human)
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh...
T75866 RFRP-3(human) TFA
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma...
T37131 MS 15203
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re...
T37477 L-858,051 (hydrochloride)
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat...
T39392 C-Type Natriuretic Peptide (CNP) (1-22), human TFA
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by hist...
T37896 AZ 1729
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay...
T70035 Tasimelteon-d5
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ...
T69530 Difelikefalin TFA
Difelikefalin TFA is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m...
T35631 Peptide YY (human) (trifluoroacetate salt) Peptide Tyrosine Tyrosine
Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-in...
T37483 Difelikefalin (trifluoroacetate salt)
Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse ...
T37199 Bilaid C
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293...
T69537 Difelikefalin HCl
Difelikefalin HCl is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m...
T83677 Neuropeptide Y (porcine, bovine) TFA NPY (porcine, bovine)
Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, ...
T83955 MOMBA
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate...
T38110 Galanin (Human) (Acetate)
Galanin (Human) (Acetate) is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50= 0.031 nM) and...
T37791 A-971432
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 &#181M, respectively). It inhibits forskolin-induced cAMP production in CHO cel...
T83697 PAMP-12 (human, mouse, rat, porcine, bovine) TFA Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni...

Compounds

L 858051
T24365
Synonym: 7B-Forskolin,L858051,Dmpb-forskolin,L-858051
Target:
1,9-Dideoxyforskolin
T22467
Synonym:
Target: Others
Deacetylforskolin
T36720
Synonym:
Target:
AM-8123
T39442
Synonym:
Target:
PG01
T16516
Synonym: Phenylglycine-01
Target: CFTR
Apelin-17 (human, bovine) acetate
TP2092L
Synonym: Apelin-17 (human, bovine) acetate(217082-57-0 free base)
Target: HIV Protease
ELA-11 (human) acetate(1784687-32-6 free base)
TP1922L1
Synonym:
Target: Apelin receptor, Arrestin
RFRP3(human) acetate(311309-27-0 free base)
TP1936L1
Synonym:
Target: Neuropeptide Y Receptor
C-Type Natriuretic Peptide (CNP) (1-22), human acetate
T39392L
Synonym: C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)
Target: Others
C-Type Natriuretic Peptide (CNP) (1-22), human
TP1187
Synonym: CNP (1-22), human
Target: RAAS
(R)-BPO-27
T10591L
Synonym:
Target: CFTR, Autophagy
CB-25
T78083
Synonym:
Target: Cannabinoid Receptor
Manoyl oxide
T33214
Synonym: Manoyl
Target:
L-759,656
T27779
Synonym: L 759,656,L759,656
Target:
Apelin-17(human, bovine)
TP2092
Synonym: Apelin-17 (human, bovine)
Target:
ELA-11(human)
TP1922
Synonym: ELA-11 (human)
Target:
ELA-11(human) TFA
T76053
Synonym:
Target:
RFRP-3(human)
TP1936
Synonym: RFRP 3 (human)
Target:
MM 54
TP2001
Synonym:
Target:
AM841
T78949
Synonym:
Target: Cannabinoid Receptor
ELA-21 (human)
TP2096
Synonym:
Target:
RFRP-3(human) TFA
T75866
Synonym:
Target:
MS 15203
T37131
Synonym:
Target:
L-858,051 (hydrochloride)
T37477
Synonym:
Target:
C-Type Natriuretic Peptide (CNP) (1-22), human TFA
T39392
Synonym:
Target:
AZ 1729
T37896
Synonym:
Target:
Tasimelteon-d5
T70035
Synonym:
Target:
Difelikefalin TFA
T69530
Synonym:
Target:
Peptide YY (human) (trifluoroacetate salt)
T35631
Synonym: Peptide Tyrosine Tyrosine
Target:
Difelikefalin (trifluoroacetate salt)
T37483
Synonym:
Target:
Bilaid C
T37199
Synonym:
Target:
Difelikefalin HCl
T69537
Synonym:
Target:
Neuropeptide Y (porcine, bovine) TFA
T83677
Synonym: NPY (porcine, bovine)
Target:
MOMBA
T83955
Synonym:
Target:
Galanin (Human) (Acetate)
T38110
Synonym:
Target:
A-971432
T37791
Synonym:
Target:
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
T83697
Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
Target:
カタログ番号 製品名 別名 ターゲット
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
TN4073 Forskolin G Others
Forskolin is known to elevate intracellular cAMP levels.
TN4074 Forskolin J Others
Forskolin J is a natural product for research related to life sciences. The catalog number is TN4074 and the CAS number is 81873-08-7.
TN1520 Isoforskolin Coleonol B IL Receptor , TNF
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.
T5081 Adenine monohydrochloride hemihydrate Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate Endogenous Metabolite , Adenosine Receptor
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a...
T16332 NKH477 Colforsin dapropate hydrochloride NMDAR
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cyt...