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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T24365 | L 858051 | 7B-Forskolin,L858051,Dmpb-forskolin,L-858051 | |
L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes. | |||
T22467 | 1,9-Dideoxyforskolin | Others | |
The compound is an inactive analog of forskolin(an adenylyl cyclase activator). | |||
T36720 | Deacetylforskolin | ||
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... | |||
T39442 | AM-8123 | ||
AM-8123 is an APJ agonist with high oral bioavailability and potency. It effectively inhibits Forskolin-stimulated cAMP production and activates Gα proteins. This compound is valuable for cardiovascular disease research. | |||
T16516 | PG01 | Phenylglycine-01 | CFTR |
TP2092L | Apelin-17 (human, bovine) acetate | Apelin-17 (human, bovine) acetate(217082-57-0 free base) | HIV Protease |
Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). | |||
TP1922L1 | ELA-11 (human) acetate(1784687-32-6 free base) | Apelin receptor , Arrestin | |
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. | |||
TP1936L1 | RFRP3(human) acetate(311309-27-0 free base) | Neuropeptide Y Receptor | |
RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced produ... | |||
T39392L | C-Type Natriuretic Peptide (CNP) (1-22), human acetate | C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base) | Others |
C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), huma... | |||
TP1187 | C-Type Natriuretic Peptide (CNP) (1-22), human | CNP (1-22), human | RAAS |
C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. | |||
T10591L | (R)-BPO-27 | CFTR , Autophagy | |
(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney. | |||
T78083 | CB-25 | Cannabinoid Receptor | |
CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells [1]. | |||
T33214 | Manoyl oxide | Manoyl | |
Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids. | |||
T27779 | L-759,656 | L 759,656,L759,656 | |
L-759,656 is highly selective CB2 receptor agonist (CB1 Ki = 4888 nM, CB2 Ki = 11.8 nM). L-759,656 potently inhibits forskolin-stimulated cAMP production in CHO cells (EC50 = 3.1 nM). | |||
TP2092 | Apelin-17(human, bovine) | Apelin-17 (human, bovine) | |
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). | |||
TP1922 | ELA-11(human) | ELA-11 (human) | |
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. | |||
T76053 | ELA-11(human) TFA | ||
ELA-11(human) TFA, a bioactive fragment of ELA-32, acts as a high-affinity apelin receptor agonist (K i =14 nM). It effectively inhibits forskolin-induced cAMP production and promotes β-arrestin recruitment in vitro, hig... | |||
TP1936 | RFRP-3(human) | RFRP 3 (human) | |
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons. | |||
TP2001 | MM 54 | ||
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv... | |||
T78949 | AM841 | Cannabinoid Receptor | |
AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi... | |||
TP2096 | ELA-21 (human) | ||
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh... | |||
T75866 | RFRP-3(human) TFA | ||
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma... | |||
T37131 | MS 15203 | ||
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re... | |||
T37477 | L-858,051 (hydrochloride) | ||
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat... | |||
T39392 | C-Type Natriuretic Peptide (CNP) (1-22), human TFA | ||
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by hist... | |||
T37896 | AZ 1729 | ||
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay... | |||
T70035 | Tasimelteon-d5 | ||
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... | |||
T69530 | Difelikefalin TFA | ||
Difelikefalin TFA is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m... | |||
T35631 | Peptide YY (human) (trifluoroacetate salt) | Peptide Tyrosine Tyrosine | |
Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-in... | |||
T37483 | Difelikefalin (trifluoroacetate salt) | ||
Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse ... | |||
T37199 | Bilaid C | ||
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293... | |||
T69537 | Difelikefalin HCl | ||
Difelikefalin HCl is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m... | |||
T83677 | Neuropeptide Y (porcine, bovine) TFA | NPY (porcine, bovine) | |
Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, ... | |||
T83955 | MOMBA | ||
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate... | |||
T38110 | Galanin (Human) (Acetate) | ||
Galanin (Human) (Acetate) is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50= 0.031 nM) and... | |||
T37791 | A-971432 | ||
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cel... | |||
T83697 | PAMP-12 (human, mouse, rat, porcine, bovine) TFA | Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20) | |
Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T2939 | Forskolin | Coleonol,Colforsin | FXR , Adenylyl cyclase , AChR , Autophagy |
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the... | |||
TN4073 | Forskolin G | Others | |
Forskolin is known to elevate intracellular cAMP levels. | |||
TN4074 | Forskolin J | Others | |
Forskolin J is a natural product for research related to life sciences. The catalog number is TN4074 and the CAS number is 81873-08-7. | |||
TN1520 | Isoforskolin | Coleonol B | IL Receptor , TNF |
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis. | |||
T5081 | Adenine monohydrochloride hemihydrate | Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate | Endogenous Metabolite , Adenosine Receptor |
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a... | |||
T16332 | NKH477 | Colforsin dapropate hydrochloride | NMDAR |
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cyt... |