|
T24365 |
L 858051
|
7B-Forskolin,L858051,Dmpb-forskolin,L-858051 |
|
|
L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes. |
|
T22467 |
1,9-Dideoxyforskolin
|
|
Others
|
|
The compound is an inactive analog of forskolin(an adenylyl cyclase activator). |
|
T36720 |
Deacetylforskolin
|
|
|
|
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... |
|
T39442 |
AM-8123
|
|
|
|
AM-8123 is an APJ agonist with high oral bioavailability and potency. It effectively inhibits Forskolin-stimulated cAMP production and activates Gα proteins. This compound is valuable for cardiovascular disease research. |
|
T16516 |
PG01
|
Phenylglycine-01 |
CFTR
|
|
|
|
TP2092L |
Apelin-17 (human, bovine) acetate
|
Apelin-17 (human, bovine) acetate(217082-57-0 free base) |
HIV Protease
|
|
Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). |
|
TP1922L1 |
ELA-11 (human) acetate(1784687-32-6 free base)
|
|
Apelin receptor
,
Arrestin
|
|
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. |
|
TP1936L1 |
RFRP3(human) acetate(311309-27-0 free base)
|
|
Neuropeptide Y Receptor
|
|
RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced produ... |
|
T39392L |
C-Type Natriuretic Peptide (1-22) acetate（human）
|
C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base) |
Others
|
|
C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), huma... |
|
TP1187 |
C-Type Natriuretic Peptide (CNP) (1-22), human
|
CNP (1-22), human |
RAAS
|
|
C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. |
|
T10591L |
(R)-BPO-27
|
|
CFTR
,
Autophagy
|
|
(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney. |
|
T78083 |
CB-25
|
|
Cannabinoid Receptor
|
|
CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells [1]. |
|
T27779 |
L-759,656
|
L 759,656,L759,656 |
|
|
L-759,656 is highly selective CB2 receptor agonist (CB1 Ki = 4888 nM, CB2 Ki = 11.8 nM). L-759,656 potently inhibits forskolin-stimulated cAMP production in CHO cells (EC50 = 3.1 nM). |
|
TP2092 |
Apelin-17(human, bovine)
|
Apelin-17 (human, bovine) |
|
|
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). |
|
T33214 |
Manoyl oxide
|
Manoyl |
|
|
Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids. |
|
TP1922 |
ELA-11(human)
|
ELA-11 (human) |
|
|
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. |
|
T76053 |
ELA-11(human) TFA
|
|
|
|
ELA-11(human) TFA, a bioactive fragment of ELA-32, acts as a high-affinity apelin receptor agonist (K i =14 nM). It effectively inhibits forskolin-induced cAMP production and promotes β-arrestin recruitment in vitro, hig... |
|
TP2001 |
MM 54
|
|
|
|
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv... |
|
TP1936 |
RFRP-3(human)
|
RFRP 3 (human) |
|
|
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons. |
|
T78949 |
AM841
|
|
Cannabinoid Receptor
|
|
AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi... |
|
T37131 |
MS 15203
|
|
|
|
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re... |
|
T37477 |
L-858,051 (hydrochloride)
|
|
|
|
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat... |
|
TP2096 |
ELA-21 (human)
|
|
|
|
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh... |
|
T75866 |
RFRP-3(human) TFA
|
|
|
|
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma... |
|
T39392 |
C-Type Natriuretic Peptide (CNP) (1-22), human TFA
|
|
|
|
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by hist... |
|
T37896 |
AZ 1729
|
|
|
|
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay... |
|
T69530 |
Difelikefalin TFA
|
|
|
|
Difelikefalin TFA is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m... |
|
T70035 |
Tasimelteon-d5
|
|
|
|
Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel ... |
|
T35631 |
Peptide YY (human) (trifluoroacetate salt)
|
Peptide Tyrosine Tyrosine |
|
|
Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-in... |
|
T37483 |
Difelikefalin (trifluoroacetate salt)
|
|
|
|
Difelikefalin is a κ-opioid receptor (KOR) agonist.1It activates KOR in HEK293 cells expressing the human receptor (EC50= 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse ... |
|
T37199 |
Bilaid C
|
|
|
|
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293... |
|
T69537 |
Difelikefalin HCl
|
|
|
|
Difelikefalin HCl is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 m... |
|
T83955 |
MOMBA
|
|
|
|
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate... |
|
T83677 |
Neuropeptide Y (porcine, bovine) TFA
|
NPY (porcine, bovine) |
|
|
Neuropeptide Y (NPY), a neuropeptide, plays roles in regulating appetite, vasoconstriction, cardiac contractility, and intestinal secretion, acting as an agonist for NPY receptors Y1, Y2, and Y5. Expressed ubiquitously, ... |
|
T38110 |
Galanin (Human) (Acetate)
|
|
|
|
Galanin (Human) (Acetate) is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50= 0.031 nM) and... |
|
T37791 |
A-971432
|
|
|
|
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cel... |
|
T83697 |
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
|
Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20) |
|
|
Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni... |
